The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

Title: The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation

Volume: 10 Issue: 5

Author(s): Y.H. Zeidan and Y.A. Hannun

Affiliation:

Keywords: Ceramide, sphingomyelinase, protein kinase C, apoptosis, cancer, membranes, sphingolipids

Abstract: One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase (ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the phosphocholine head group of sphingomyelin to generate ceramide. Cumulative efforts of various laboratories over the past 40 years have placed ASMase and its product ceramide at the forefront of lipid research. Activation of the ASMase/ceramide pathway is a shared response to an ever-growing list of receptor and non-receptor mediated forms of cellular stress including: death ligands (TNFα, TRAIL, Fas ligand), cytokines (IL-1, IFNγ), radiation, pathogenic infections, cytotoxic agents and others. The strategic role of ASMase in lipid metabolism and cellular stress response has sparked interest in investigatig the molecular mechanisms underlying ASMase activation. In this article, we review the translational role of the ASMase/ceramide pathway and recent advances on its mechanisms of regulation.

Cite this article as:

Zeidan Y.H. and Hannun Y.A., The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation, Current Molecular Medicine 2010; 10 (5) . https://dx.doi.org/10.2174/156652410791608225