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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Recent Advances on Platensimycin: A Potential Antimicrobial Agent

Author(s): Xiaoyun Lu and Qidong You

Volume 17, Issue 12, 2010

Page: [1139 - 1155] Pages: 17

DOI: 10.2174/092986710790827852

Price: $65

Abstract

Platensimycin, an active metabolite of Streptomyces platensis, was initially discovered by a combination of RNA interferin induced gene-silencing and library screening to microbial extracts. Platensimycin selectively inhibits β- ketoacyl-acyl carrier protein (ACP) synthase II (FabF) that is recognized as an effective broad-spectrum antibiotic against drug-resistant microorganism strains. Its novel scaffold and extraordinary antibacterial activity have drawn great attentions in recent years. So far, a number of synthetic strategies have been explored for the total synthesis of platensimycin. Moreover, many analogues have been investigated in terms of structure-activity relationships (SAR). This review provides a detailed overview of updated studies on platensimycin, focusing on various total and formal synthetic strategies, development of analogues, and the structure-activity relationships.

Keywords: Platensimycin, FabF, antibiotic, discovery, platencin, total synthetic strategies, analogues, SAR


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