Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures

Title: Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures

Volume: 6 Issue: 1

Author(s): Ahmed Kamal, K. L. Reddy, V. Devaiah, N. Shankaraiah and M. V. Rao

Affiliation:

Keywords: benzodiazepine receptor, solid support, Quinazoline derivatives, cell adhesion receptor, cyclocondensation, fibrinogen receptor antagonists, Rink-amide resin

Abstract: Quinoxaline, quinazoline and benzimidazole based templates have been synthesized on solid-support employing different methodologies. This review enlightens academic and industrial examples of combinatorial synthesis for this type of heterocycles that appeared in the literature in the last decade. Hence, some of the important synthetic strategies for the generation of quinoxaline, quinazoline and benzimidazole based privileged structures, and the important biological activities for these heterocycles have been highlighted. Further, benzothiadiazinone, thioxoquinazolinone, cinnoline and indazole are also examined in this review.

Cite this article as:

Kamal Ahmed, Reddy L. K., Devaiah V., Shankaraiah N. and Rao V. M., Recent Advances in the Solid-Phase Combinatorial Synthetic Strategies for the Quinoxaline, Quinazoline and Benzimidazole Based Privileged Structures, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197839