Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products

Title: Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products

Volume: 6 Issue: 1

Author(s): Alvarez Cironi, Mercedes Alvarez and Fernando Albericio

Affiliation:

Keywords: Pictet-Spengler reaction, dehydrative cyclization, antitumor, prostaglandin, Combinatorial libraries, galanthamine-like compounds, carpanone

Abstract: Solid-phase chemistry, first introduced for peptide synthesis in the 1960s, has become an integral part of organic synthetic methodology. Presented herein is an overview of recent examples of the use of solid-phase in the preparation of non-peptidic natural products and related compounds, encompassing on-resin total syntheses as well as the use of polymer-supported reagents in solution.

Cite this article as:

Cironi Alvarez, Alvarez Mercedes and Albericio Fernando, Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products, Mini-Reviews in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/138955706775197857