Abstract
Pyridinium aldoximes are used as antidotes in organophosphate poisoning. In the reactivation process they form a complex with the organophosphates, even if the serine active site of acetylcholinesterase enzymes has been inactivated by the organophosphorus compounds. Essential disadvantage of the previously used pyridinium aldoximes is the instability and the toxicity of these complexes. Novel pyridinium aldoximes show more effective detoxifying effects. A general scheme of the synthesis of several novel and very promising pyridinium aldoximes and their basic characteristics are shown in this paper.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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