Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

Title: Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes

Volume: 10 Issue: 4

Author(s): Luca Ronconi, Donatella Aldinucci, Q. Ping Dou and Dolores Fregona

Affiliation:

Keywords: Anticancer drug, Dithiocarbamate, Gold compounds, Metallodrug, Nephrotoxicity, Proteasome inhibitor, Reactive oxygen species (ROS), Thioredoxin reductase (TrxR)

Abstract: In this review paper we aim at giving a detailed overview on our research work devoted to the design of gold-based anticancer agents. In particular, during the last decade, we have been developing some gold(III)-dithiocarbamato derivates showing outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference clinically-established anticancer drug cisplatin. Starting from the rationale behind our investigations, we here summarize the results achieved so far, focusing on the latest in-depth mechanistic studies that have recently provided insights into their mechanism of action, thus opening up new prospects for further pharmacological testing and, hopefully, to enter clinical trials.

Cite this article as:

Ronconi Luca, Aldinucci Donatella, Ping Dou Q. and Fregona Dolores, Latest Insights into the Anticancer Activity of Gold(III)-Dithiocarbamato Complexes, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (4) . https://dx.doi.org/10.2174/187152010791162298