Abstract
Major aspects of multicomponent synthesis of cyclic frameworks are reviewed with special focus on Knoevenagel-based domino reactions. Particularly, the Knoevenagel-Cycloaddition and the Knoevenagel-Michael cascades are the majority of reaction types which contribute to the building of complicated cyclic molecular scaffolds. Although samples of the other Knoevenagel-induced reactions are not abundant, their creativity in production of novel cyclic structures should not be neglected. The presented reports herein are sufficient enough to confirm that Knoevenagel-induced domino reactions have been one of the most powerful and productive tools for the construction of novel and complicated frameworks.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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