Abstract
The Povarov reaction is a multicomponent process involving anilines, carbonyl compounds and activated olefins to afford tetrahydroquinolines. The mechanism of this domino reaction comprises a sequence of steps linking imine formation, a Mannich-type reaction and an intramolecular aromatic electrophilic substitution. Here we analyze the scope of the methodology, with a particular emphasis on mechanistic variations, new synthetic inputs, reaction modes, structural diversity originated from this process and its applications to organic chemistry.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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