Abstract
Hepatocyte growth factor (HGF) and its receptor, cMET, have become the focus on intense scrutiny since its discovery in the late 1980s [1, 2] as regards it role in cancer. HGF is now known to be a potent morphogen that can regulate tissue and organ regeneration and modulate cell morphology, it is a motogen that can stimulate cell motility and migration, and is a mitogen able to regulate cell growth and death and as an angiogenic factor [3]. HGF is can induce both angiogenesis and lymphangiogenesis [3a; 4]. That HGF and cMET have such a diversity of functions has led to intense interest in the clinical setting due to their potential in their prognostic aspect and therapeutic implications as imaging tools. This issue will focus on recent work that shows strong indications for the value of HGF and cMET in clinical settings.
Keywords: Hepatocyte growth factor, cMET, angiogenesis, metastasis, imaging, cancer treatment
Anti-Cancer Agents in Medicinal Chemistry
Title: Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy
Volume: 10 Issue: 1
Author(s): Tracey A. Martin and Wen G. Jiang
Affiliation:
Keywords: Hepatocyte growth factor, cMET, angiogenesis, metastasis, imaging, cancer treatment
Abstract: Hepatocyte growth factor (HGF) and its receptor, cMET, have become the focus on intense scrutiny since its discovery in the late 1980s [1, 2] as regards it role in cancer. HGF is now known to be a potent morphogen that can regulate tissue and organ regeneration and modulate cell morphology, it is a motogen that can stimulate cell motility and migration, and is a mitogen able to regulate cell growth and death and as an angiogenic factor [3]. HGF is can induce both angiogenesis and lymphangiogenesis [3a; 4]. That HGF and cMET have such a diversity of functions has led to intense interest in the clinical setting due to their potential in their prognostic aspect and therapeutic implications as imaging tools. This issue will focus on recent work that shows strong indications for the value of HGF and cMET in clinical settings.
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Cite this article as:
Martin A. Tracey and Jiang G. Wen, Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/1871520611009010002
DOI https://dx.doi.org/10.2174/1871520611009010002 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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