Targeting Prostate Cancer Stem Cells

Title: Targeting Prostate Cancer Stem Cells

Volume: 9 Issue: 10

Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar and Elaine M. Hurt

Affiliation:

Keywords: Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin

Abstract: Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

Cite this article as:

Crea Francesco, Mathews A. Lesley, Farrar L. William and Hurt M. Elaine, Targeting Prostate Cancer Stem Cells, Anti-Cancer Agents in Medicinal Chemistry 2009; 9 (10) . https://dx.doi.org/10.2174/187152009789735053