Abstract
3,3-Benzene-1,4-diylbis(1-phenylprop-2-enone) 3 reacted with 2-cyanoethanethioamide 4 to afford the corresponding 4,4-benzene-1,4-diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) 5. The synthetic potentiality of compound 5 was investigated in the present study via its reactions with several active-hydrogen containing compounds 6a-f aiming to synthesize 4,4-(1,4-phenylene)bis(3-amino-6-phenylthieno[2,3-b]pyridine) derivatives 8a-h directly in case of 8d,e,f,h and via 2,2-{1,4-Phenylenebis[(3-cyano-6-phenylpyridine-4,2- diyl)thio]} derivatives 7a-c,g in case of 8a-c,g. The structures of all the newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1 H NMR, mass spectra as well as that of elemental analyses. Anti-cancer activities for all the newly synthesized heterocyclic compounds were investigated.
Current Organic Chemistry
Title: Novel Synthesis, Reactions and anti-Cancer Activities of 4,4-Benzene-1,4- diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile)
Volume: 13 Issue: 17
Author(s): Azza M. Abdel-Fattah and Mohamed M. Elsayed
Affiliation:
Abstract: 3,3-Benzene-1,4-diylbis(1-phenylprop-2-enone) 3 reacted with 2-cyanoethanethioamide 4 to afford the corresponding 4,4-benzene-1,4-diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) 5. The synthetic potentiality of compound 5 was investigated in the present study via its reactions with several active-hydrogen containing compounds 6a-f aiming to synthesize 4,4-(1,4-phenylene)bis(3-amino-6-phenylthieno[2,3-b]pyridine) derivatives 8a-h directly in case of 8d,e,f,h and via 2,2-{1,4-Phenylenebis[(3-cyano-6-phenylpyridine-4,2- diyl)thio]} derivatives 7a-c,g in case of 8a-c,g. The structures of all the newly synthesized heterocyclic compounds were elucidated by considering the data of IR, 1 H NMR, mass spectra as well as that of elemental analyses. Anti-cancer activities for all the newly synthesized heterocyclic compounds were investigated.
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Cite this article as:
Abdel-Fattah M. Azza and Elsayed M. Mohamed, Novel Synthesis, Reactions and anti-Cancer Activities of 4,4-Benzene-1,4- diylbis(6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile), Current Organic Chemistry 2009; 13 (17) . https://dx.doi.org/10.2174/138527209789578036
DOI https://dx.doi.org/10.2174/138527209789578036 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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