Abstract
The Blood Brain Barrier (BBB) represents a fundamental challenge towards development of therapy for disease in the brain such as brain tumor, Parkinsons disease and Alzheimers disease. The passage across the BBB is vital to the success of a therapeutic platform and nanotechnology based systems provide great potential for solving the problem. This chapter discusses the structures and functions of the BBB, the transport mechanisms at the BBB, the strategies for crossing the BBB, and nanostructures for delivering drugs and imaging in the brain.
Keywords: Blood brain barrier, nanoparticles, nanomaterials, drug delivery, imaging
Current Bioactive Compounds
Title: Nanostructures for Bypassing Blood Brain Barrier
Volume: 5 Issue: 3
Author(s): Junping Wang, Chandra M. Valmikinathan and Xiaojun Yu
Affiliation:
Keywords: Blood brain barrier, nanoparticles, nanomaterials, drug delivery, imaging
Abstract: The Blood Brain Barrier (BBB) represents a fundamental challenge towards development of therapy for disease in the brain such as brain tumor, Parkinsons disease and Alzheimers disease. The passage across the BBB is vital to the success of a therapeutic platform and nanotechnology based systems provide great potential for solving the problem. This chapter discusses the structures and functions of the BBB, the transport mechanisms at the BBB, the strategies for crossing the BBB, and nanostructures for delivering drugs and imaging in the brain.
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Cite this article as:
Wang Junping, Valmikinathan M. Chandra and Yu Xiaojun, Nanostructures for Bypassing Blood Brain Barrier, Current Bioactive Compounds 2009; 5 (3) . https://dx.doi.org/10.2174/157340709789054777
DOI https://dx.doi.org/10.2174/157340709789054777 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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