Single-Molecule Protein Interaction Conformational Dynamics

Title: Single-Molecule Protein Interaction Conformational Dynamics

Volume: 10 Issue: 5

Author(s): H. Peter Lu

Affiliation:

Abstract: Protein conformational fluctuations and dynamics, often associated with static and dynamic inhomogeneities, play a crucial role in biomolecular functions. It is extremely difficult to characterize such spatially and temporally inhomogeneous dynamics in an ensemble-averaged measurement, especially when the proteins involve in a multiple-step and multiple-conformation complex chemical interactions and transformations, such as in protein-protein interactions and protein- DNA interactions. Single-molecule spectroscopy is a powerful approach to analyze protein conformational dynamics under physiological conditions, providing dynamic perspectives on a molecular-level understanding of protein structurefunction mechanisms.

Cite this article as:

Lu Peter H., Single-Molecule Protein Interaction Conformational Dynamics, Current Pharmaceutical Biotechnology 2009; 10 (5) . https://dx.doi.org/10.2174/138920109788922119