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Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

The No-Reflow Phenomenon in the Coronary Circulation

Author(s): Thomas J. Kiernan, Nicholas J. Ruggiero II, Juan M. Bernal, Creighton W. Don, Christian Witzke, Gareth D. Kiernan, Roberto J. Cubeddu and Bryan P. Yan

Volume 7, Issue 3, 2009

Page: [181 - 192] Pages: 12

DOI: 10.2174/187152509789105426

Price: $65

Abstract

The no-reflow phenomenon is a poorly understood complication of percutaneous coronary intervention in which diminished blood flow to distal microvascular beds persists despite the successful treatment of the occlusive lesion from the epicardial coronary artery or arteries. In this contemporary review we endeavour to discuss the pathophysiology of coronary no-reflow, understand the predictors and describe current pharmacological and mechanical strategies to prevent and treat coronary no-reflow.

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