Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism

Lu      Tian; Guiqin      Liu; Junjun      Han; Xiangyang      Li

doi:10.2174/0113892002318723240802100729

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Abstract

Sedative hypnotics effectively improve sleep quality under high-altitude hypoxia by reducing central nervous system excitability. High-altitude hypoxia causes sleep disorders and modifies the metabolism and mechanisms of drug action, impacting medication therapy's effectiveness. This review aims to provide a theoretical basis for the treatment of central nervous system diseases in high-altitude areas by summarizing the progress and mechanism of sedative-hypnotics in hypoxic environments, as well as the impact of highaltitude hypoxia on sleep.

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DOI https://dx.doi.org/10.2174/0113892002318723240802100729	Print ISSN 1389-2002
Publisher Name Bentham Science Publisher	Online ISSN 1875-5453

Current Drug Metabolism

Effects of High-altitude Hypoxia on Drug Metabolism and Pharmacokinetics of Sedative-hypnotic Drugs and Regulatory Mechanism

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