Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders

Title:Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders

Volume: 24

Author(s): Kuldeep Singh*, Jeetendra Kumar Gupta, Pranshul Sethi, Sojomon Mathew, Alok Bhatt, Mukesh Chandra Sharma, Sunam Saha, Dr. Shamim and Shivendra Kumar

Affiliation:

• Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura Uttar Pradesh, India

Abstract: Neurological disorders, characterized by oxidative stress (OS) and inflammation, have become a major global health concern. Redox reactions play a vital role in regulating the balance of the neuronal microenvironment. Specifically, the imbalance leads to a significant weakening of the organism's natural defensive mechanisms. This, in turn, causes the development of harmful oxidative stress, which plays a crucial role in the onset and progression of neurodegenerative dis-eases. The quest for effective therapeutic agents has led to significant advancements in the syn-thesis of antioxidant derivatives. This review provides a comprehensive overview of the recent developments in the use of novel antioxidant compounds with potential pharmacological applica-tions in the management of neurological disorders. The discussed compounds encompass a di-verse range of chemical structures, including polyphenols, vitamins, flavonoids, and hybrid mole-cules, highlighting their varied mechanisms of action. This review also focuses on the mechanism of oxidative stress in developing neurodegenerative disease. The neuroprotective effects of these antioxidant derivatives are explored in the context of specific neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. The ultimate goal is to pro-vide effective treatments for these debilitating conditions and improve the quality of life for pa-tients.

Cite this article as:

Singh Kuldeep*, Gupta Jeetendra Kumar, Sethi Pranshul, Mathew Sojomon, Bhatt Alok, Sharma Mukesh Chandra, Saha Sunam, Shamim Dr. and Kumar Shivendra, Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders, Current Topics in Medicinal Chemistry 2024; 24 () . https://dx.doi.org/10.2174/0115680266305736240725052825