Huangqi Guizhi Wuwu Decoction Improves Inflammatory Factor Levels in Chemotherapy-induced Peripheral Neuropathy by Regulating the Arachidonic Acid Metabolic Pathway

Title:Huangqi Guizhi Wuwu Decoction Improves Inflammatory Factor Levels in Chemotherapy-induced Peripheral Neuropathy by Regulating the Arachidonic Acid Metabolic Pathway

Volume: 30

Author(s): Shanshan Wang, Xiaohui Du, Guangli Yan, Le Yang, Hui Sun, Xiwu Zhang, Ling Kong, Ying Han, Di Han, Songyuan Tang and Xijun Wang*

Affiliation:

• State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, China

Abstract: Background: Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common complication that arises from the use of anticancer drugs. Huangqi Guizhi Wuwu Decoction (HGWWD) is an effective classic prescription for treating CIPN however, the mechanism of the activity is not entirely understood.

Objective: This study aimed to investigate the remedial effects and mechanisms of HGWWD on CIPN.

Methods: Changes in behavioral biochemical histopathological and biomarker indices were used to evaluate the efficacy of HGWWD treatment. Ultra-high-performance liquid chromatography/mass spectrometry combined with the pattern recognition method was used to screen biomarkers and metabolic pathways related to CIPN. The results of pathway analyses were verified by protein blotting experiments.

Results: A total of 29 potential biomarkers were identified and 13 metabolic pathways were found to be involved in CIPN. In addition HGWWD reversed the levels of 19 biomarkers. Prostaglandin H2 and 17α 21-dihydroxypregnenolone were targeted as core biomarkers.

Conclusion: This study provides scientific evidence to support the finding that HGWWD mainly inhibits the inflammatory response during CIPN by regulating arachidonic acid metabolism.

Cite this article as:

Wang Shanshan, Du Xiaohui, Yan Guangli, Yang Le, Sun Hui, Zhang Xiwu, Kong Ling, Han Ying, Han Di, Tang Songyuan and Wang Xijun*, Huangqi Guizhi Wuwu Decoction Improves Inflammatory Factor Levels in Chemotherapy-induced Peripheral Neuropathy by Regulating the Arachidonic Acid Metabolic Pathway, Current Pharmaceutical Design 2024; 30 () . https://dx.doi.org/10.2174/0113816128308622240709102830

DOI https://dx.doi.org/10.2174/0113816128308622240709102830	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286