Generic placeholder image

Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Research Article

Bibliometric Analysis of Alzheimer's Disease and Depression

In Press, (this is not the final "Version of Record"). Available online 31 July, 2024
Author(s): Sixin Li, Qian Zhang, Jian Liu, Nan Zhang, Xinyu Li, Ying Liu, Huiwen Qiu, Jing Li* and Hui Cao*
Published on: 31 July, 2024

DOI: 10.2174/1570159X22666240730154834

Price: $95

Abstract

Background: The link between Alzheimer's disease and depression has been confirmed by clinical and epidemiological research. Therefore, our study examined the literary landscape and prevalent themes in depression-related research works on Alzheimer's disease through bibliometric analysis.

Methods: Relevant literature was identified from the Web of Science core collection. Bibliometric parameters were extracted, and the major contributors were defined in terms of countries, institutions, authors, and articles using Microsoft Excel 2019 and VOSviewer. VOSviewer and CiteSpace were employed to visualize the scientific networks and seminal topics.

Results: The analysis of literature utilised 10,553 articles published from 1991 until 2023. The three countries or regions with the most publications were spread across the United States, China, and England. The University of Toronto and the University of Pittsburgh were the major contributors to the institutions. Lyketsos, Constantine G., Cummings, JL were found to make outstanding contributions. Journal of Alzheimer's Disease was identified as the most productive journal. Furthermore, “Alzheimer’s”, “depression”, “dementia”, and “mild cognitive decline” were the main topics of discussion during this period.

Limitations: Data were searched from a single database to become compatible with VOSviewer and CiteSpace, leading to a selection bias. Manuscripts in English were considered, leading to a language bias.

Conclusion: Articles on “Alzheimer’s” and “depression” displayed an upward trend. The prevalent themes addressed were the mechanisms of depression-associated Alzheimer's disease, the identification of depression and cognitive decline in the early stages of Alzheimer's, alleviating depression and improving life quality in Alzheimer's patients and their caregivers, and diagnosing and treating neuropsychiatric symptoms in Alzheimer. Future research on these hot topics would promote understanding in this field.

[1]
Li, X.; Feng, X.; Sun, X.; Hou, N.; Han, F.; Liu, Y. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2019. Front. Aging Neurosci., 2022, 14, 937486.
[http://dx.doi.org/10.3389/fnagi.2022.937486] [PMID: 36299608]
[2]
Brookmeyer, R.; Abdalla, N.; Kawas, C.H.; Corrada, M.M. Forecasting the prevalence of preclinical and clinical Alzheimer’s disease in the United States. Alzheimers Dement., 2018, 14(2), 121-129.
[http://dx.doi.org/10.1016/j.jalz.2017.10.009] [PMID: 29233480]
[3]
Jack, C.R., Jr; Therneau, T.M.; Weigand, S.D.; Wiste, H.J.; Knopman, D.S.; Vemuri, P.; Lowe, V.J.; Mielke, M.M.; Roberts, R.O.; Machulda, M.M.; Graff-Radford, J.; Jones, D.T.; Schwarz, C.G.; Gunter, J.L.; Senjem, M.L.; Rocca, W.A.; Petersen, R.C. Prevalence of biologically vs. clinically defined alzheimer spectrum entities using the national institute on aging-alzheimer’s association research framework. JAMA Neurol., 2019, 76(10), 1174-1183.
[http://dx.doi.org/10.1001/jamaneurol.2019.1971] [PMID: 31305929]
[4]
Zhang, H.; Ji, J. Prevalence of mental disorders in China. Lancet Psychiatry, 2019, 6(3), 188-189.
[http://dx.doi.org/10.1016/S2215-0366(19)30034-3] [PMID: 30792113]
[5]
Collaborators, G.B.D.M.D. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry, 2022, 9(2), 137-150.
[http://dx.doi.org/10.1016/S2215-0366(21)00395-3] [PMID: 35026139]
[6]
Henriques-Calado, J.; Duarte-Silva, M.E.; Sousa Ferreira, A. Depressive vulnerability in women with Alzheimer’s disease: Relationship with personality traits and abnormal personality dimensions. J. Affect. Disord., 2018, 241, 182-191.
[http://dx.doi.org/10.1016/j.jad.2018.08.004] [PMID: 30125822]
[7]
Xu, J.; Li, Q.; Qin, W.; Jun, Li. M.; Zhuo, C.; Liu, H.; Liu, F.; Wang, J.; Schumann, G.; Yu, C. Neurobiological substrates underlying the effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment. Brain, 2018, 141(12), 3457-3471.
[http://dx.doi.org/10.1093/brain/awy277] [PMID: 30445590]
[8]
Wu, Y.; Wu, X.; Wei, Q.; Wang, K.; Tian, Y. Differences in cerebral structure associated with depressive symptoms in the elderly with Alzheimer’s Disease. Front. Aging Neurosci., 2020, 12, 107.
[http://dx.doi.org/10.3389/fnagi.2020.00107] [PMID: 32477094]
[9]
Pan, X.; Yan, E.; Cui, M.; Hua, W. Examining the usage, citation, and diffusion patterns of bibliometric mapping software: A comparative study of three tools. J. Informetrics, 2018, 12(2), 481-493.
[http://dx.doi.org/10.1016/j.joi.2018.03.005]
[10]
Zhang, Q.; Li, J.; Weng, L. A bibliometric analysis of COVID-19 publications in neurology by using the visual mapping method. Front. Public Health, 2022, 10, 937008.
[http://dx.doi.org/10.3389/fpubh.2022.937008] [PMID: 35958855]
[11]
Kokol, P.; Blažun Vošner, H.; Završnik, J. Application of bibliometrics in medicine: A historical bibliometrics analysis. Health Info. Libr. J., 2021, 38(2), 125-138.
[http://dx.doi.org/10.1111/hir.12295] [PMID: 31995273]
[12]
van Eck, N.J.; Waltman, L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2), 523-538.
[http://dx.doi.org/10.1007/s11192-009-0146-3] [PMID: 20585380]
[13]
Chen, C. CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature. J. Am. Soc. Inf. Sci. Technol., 2006, 57(3), 359-377.
[http://dx.doi.org/10.1002/asi.20317]
[14]
Zhang, Q.; Li, S.; Liu, J.; Chen, J. Global trends in nursing-related research on COVID-19: A bibliometric analysis. Front. Public Health, 2022, 10, 933555.
[http://dx.doi.org/10.3389/fpubh.2022.933555] [PMID: 35923953]
[15]
Vos, T.; Abajobir, A.A.; Abate, K.H.; Abbafati, C.; Abbas, K.M.; Abd-Allah, F.; Abdulkader, R.S.; Abdulle, A.M.; Abebo, T.A.; Abera, S.F.; Aboyans, V.; Abu-Raddad, L.J.; Ackerman, I.N.; Adamu, A.A.; Adetokunboh, O.; Afarideh, M.; Afshin, A.; Agarwal, S.K.; Aggarwal, R.; Agrawal, A.; Agrawal, S.; Ahmadieh, H.; Ahmed, M.B.; Aichour, M.T.E.; Aichour, A.N.; Aichour, I.; Aiyar, S.; Akinyemi, R.O.; Akseer, N.; Al Lami, F.H.; Alahdab, F.; Al-Aly, Z.; Alam, K.; Alam, N.; Alam, T.; Alasfoor, D.; Alene, K.A.; Ali, R.; Alizadeh-Navaei, R.; Alkerwi, A.; Alla, F.; Allebeck, P.; Allen, C.; Al-Maskari, F.; Al-Raddadi, R.; Alsharif, U.; Alsowaidi, S.; Altirkawi, K.A.; Amare, A.T.; Amini, E.; Ammar, W.; Amoako, Y.A.; Andersen, H.H.; Antonio, C.A.T.; Anwari, P.; Ärnlöv, J.; Artaman, A.; Aryal, K.K.; Asayesh, H.; Asgedom, S.W.; Assadi, R.; Atey, T.M.; Atnafu, N.T.; Atre, S.R.; Avila-Burgos, L.; Avokphako, E.F.G.A.; Awasthi, A.; Bacha, U.; Badawi, A.; Balakrishnan, K.; Banerjee, A.; Bannick, M.S.; Barac, A.; Barber, R.M.; Barker-Collo, S.L.; Bärnighausen, T.; Barquera, S.; Barregard, L.; Barrero, L.H.; Basu, S.; Battista, B.; Battle, K.E.; Baune, B.T.; Bazargan-Hejazi, S.; Beardsley, J.; Bedi, N.; Beghi, E.; Béjot, Y.; Bekele, B.B.; Bell, M.L.; Bennett, D.A.; Bensenor, I.M.; Benson, J.; Berhane, A.; Berhe, D.F.; Bernabé, E.; Betsu, B.D.; Beuran, M.; Beyene, A.S.; Bhala, N.; Bhansali, A.; Bhatt, S.; Bhutta, Z.A.; Biadgilign, S.; Bicer, B.K.; Bienhoff, K.; Bikbov, B.; Birungi, C.; Biryukov, S.; Bisanzio, D.; Bizuayehu, H.M.; Boneya, D.J.; Boufous, S.; Bourne, R.R.A.; Brazinova, A.; Brugha, T.S.; Buchbinder, R.; Bulto, L.N.B.; Bumgarner, B.R.; Butt, Z.A.; Cahuana-Hurtado, L.; Cameron, E.; Car, M.; Carabin, H.; Carapetis, J.R.; Cárdenas, R.; Carpenter, D.O.; Carrero, J.J.; Carter, A.; Carvalho, F.; Casey, D.C.; Caso, V.; Castañeda-Orjuela, C.A.; Castle, C.D.; Catalá-López, F.; Chang, H-Y.; Chang, J-C.; Charlson, F.J.; Chen, H.; Chibalabala, M.; Chibueze, C.E.; Chisumpa, V.H.; Chitheer, A.A.; Christopher, D.J.; Ciobanu, L.G.; Cirillo, M.; Colombara, D.; Cooper, C.; Cortesi, P.A.; Criqui, M.H.; Crump, J.A.; Dadi, A.F.; Dalal, K.; Dandona, L.; Dandona, R. das Neves, J.; Davitoiu, D.V.; de Courten, B.; De Leo, D.D.; Defo, B.K.; Degenhardt, L.; Deiparine, S.; Dellavalle, R.P.; Deribe, K.; Des Jarlais, D.C.; Dey, S.; Dharmaratne, S.D.; Dhillon, P.K.; Dicker, D.; Ding, E.L.; Djalalinia, S.; Do, H.P.; Dorsey, E.R.; dos Santos, K.P.B.; Douwes-Schultz, D.; Doyle, K.E.; Driscoll, T.R.; Dubey, M.; Duncan, B.B.; El-Khatib, Z.Z.; Ellerstrand, J.; Enayati, A.; Endries, A.Y.; Ermakov, S.P.; Erskine, H.E.; Eshrati, B.; Eskandarieh, S.; Esteghamati, A.; Estep, K.; Fanuel, F.B.B.; Farinha, C.S.E.S.; Faro, A.; Farzadfar, F.; Fazeli, M.S.; Feigin, V.L.; Fereshtehnejad, S-M.; Fernandes, J.C.; Ferrari, A.J.; Feyissa, T.R.; Filip, I.; Fischer, F.; Fitzmaurice, C.; Flaxman, A.D.; Flor, L.S.; Foigt, N.; Foreman, K.J.; Franklin, R.C.; Fullman, N.; Fürst, T.; Furtado, J.M.; Futran, N.D.; Gakidou, E.; Ganji, M.; Garcia-Basteiro, A.L.; Gebre, T.; Gebrehiwot, T.T.; Geleto, A.; Gemechu, B.L.; Gesesew, H.A.; Gething, P.W.; Ghajar, A.; Gibney, K.B.; Gill, P.S.; Gillum, R.F.; Ginawi, I.A.M.; Giref, A.Z.; Gishu, M.D.; Giussani, G.; Godwin, W.W.; Gold, A.L.; Goldberg, E.M.; Gona, P.N.; Goodridge, A.; Gopalani, S.V.; Goto, A.; Goulart, A.C.; Griswold, M.; Gugnani, H.C.; Gupta, R.; Gupta, R.; Gupta, T.; Gupta, V.; Hafezi-Nejad, N.; Hailu, G.B.; Hailu, A.D.; Hamadeh, R.R.; Hamidi, S.; Handal, A.J.; Hankey, G.J.; Hanson, S.W.; Hao, Y.; Harb, H.L.; Hareri, H.A.; Haro, J.M.; Harvey, J.; Hassanvand, M.S.; Havmoeller, R.; Hawley, C.; Hay, S.I.; Hay, R.J.; Henry, N.J.; Heredia-Pi, I.B.; Hernandez, J.M.; Heydarpour, P.; Hoek, H.W.; Hoffman, H.J.; Horita, N.; Hosgood, H.D.; Hostiuc, S.; Hotez, P.J.; Hoy, D.G.; Htet, A.S.; Hu, G.; Huang, H.; Huynh, C.; Iburg, K.M.; Igumbor, E.U.; Ikeda, C.; Irvine, C.M.S.; Jacobsen, K.H.; Jahanmehr, N.; Jakovljevic, M.B.; Jassal, S.K.; Javanbakht, M.; Jayaraman, S.P.; Jeemon, P.; Jensen, P.N.; Jha, V.; Jiang, G.; John, D.; Johnson, S.C.; Johnson, C.O.; Jonas, J.B.; Jürisson, M.; Kabir, Z.; Kadel, R.; Kahsay, A.; Kamal, R.; Kan, H.; Karam, N.E.; Karch, A.; Karema, C.K.; Kasaeian, A.; Kassa, G.M.; Kassaw, N.A.; Kassebaum, N.J.; Kastor, A.; Katikireddi, S.V.; Kaul, A.; Kawakami, N.; Keiyoro, P.N.; Kengne, A.P.; Keren, A.; Khader, Y.S.; Khalil, I.A.; Khan, E.A.; Khang, Y-H.; Khosravi, A.; Khubchandani, J.; Kiadaliri, A.A.; Kieling, C.; Kim, Y.J.; Kim, D.; Kim, P.; Kimokoti, R.W.; Kinfu, Y.; Kisa, A.; Kissimova-Skarbek, K.A.; Kivimaki, M.; Knudsen, A.K.; Kokubo, Y.; Kolte, D.; Kopec, J.A.; Kosen, S.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.; Krishnaswami, S.; Krohn, K.J.; Kumar, G.A.; Kumar, P.; Kumar, S.; Kyu, H.H.; Lal, D.K.; Lalloo, R.; Lambert, N.; Lan, Q.; Larsson, A.; Lavados, P.M.; Leasher, J.L.; Lee, P.H.; Lee, J-T.; Leigh, J.; Leshargie, C.T.; Leung, J.; Leung, R.; Levi, M.; Li, Y.; Li, Y.; Li Kappe, D.; Liang, X.; Liben, M.L.; Lim, S.S.; Linn, S.; Liu, P.Y.; Liu, A.; Liu, S.; Liu, Y.; Lodha, R.; Logroscino, G.; London, S.J.; Looker, K.J.; Lopez, A.D.; Lorkowski, S.; Lotufo, P.A.; Low, N.; Lozano, R.; Lucas, T.C.D.; Macarayan, E.R.K.; Magdy Abd El Razek, H.; Magdy Abd El Razek, M.; Mahdavi, M.; Majdan, M.; Majdzadeh, R.; Majeed, A.; Malekzadeh, R.; Malhotra, R.; Malta, D.C.; Mamun, A.A.; Manguerra, H.; Manhertz, T.; Mantilla, A.; Mantovani, L.G.; Mapoma, C.C.; Marczak, L.B.; Martinez-Raga, J.; Martins-Melo, F.R.; Martopullo, I.; März, W.; Mathur, M.R.; Mazidi, M.; McAlinden, C.; McGaughey, M.; McGrath, J.J.; McKee, M.; McNellan, C.; Mehata, S.; Mehndiratta, M.M.; Mekonnen, T.C.; Memiah, P.; Memish, Z.A.; Mendoza, W.; Mengistie, M.A.; Mengistu, D.T.; Mensah, G.A.; Meretoja, T.J.; Meretoja, A.; Mezgebe, H.B.; Micha, R.; Millear, A.; Miller, T.R.; Mills, E.J.; Mirarefin, M.; Mirrakhimov, E.M.; Misganaw, A.; Mishra, S.R.; Mitchell, P.B.; Mohammad, K.A.; Mohammadi, A.; Mohammed, K.E.; Mohammed, S.; Mohanty, S.K.; Mokdad, A.H.; Mollenkopf, S.K.; Monasta, L.; Montico, M.; Moradi-Lakeh, M.; Moraga, P.; Mori, R.; Morozoff, C.; Morrison, S.D.; Moses, M.; Mountjoy-Venning, C.; Mruts, K.B.; Mueller, U.O.; Muller, K.; Murdoch, M.E.; Murthy, G.V.S.; Musa, K.I.; Nachega, J.B.; Nagel, G.; Naghavi, M.; Naheed, A.; Naidoo, K.S.; Naldi, L.; Nangia, V.; Natarajan, G.; Negasa, D.E.; Negoi, R.I.; Negoi, I.; Newton, C.R.; Ngunjiri, J.W.; Nguyen, T.H.; Nguyen, Q.L.; Nguyen, C.T.; Nguyen, G.; Nguyen, M.; Nichols, E.; Ningrum, D.N.A.; Nolte, S.; Nong, V.M.; Norrving, B.; Noubiap, J.J.N.; O’Donnell, M.J.; Ogbo, F.A.; Oh, I-H.; Okoro, A.; Oladimeji, O.; Olagunju, T.O.; Olagunju, A.T.; Olsen, H.E.; Olusanya, B.O.; Olusanya, J.O.; Ong, K.; Opio, J.N.; Oren, E.; Ortiz, A.; Osgood-Zimmerman, A.; Osman, M.; Owolabi, M.O.; Pa, M.; Pacella, R.E.; Pana, A.; Panda, B.K.; Papachristou, C.; Park, E-K.; Parry, C.D.; Parsaeian, M.; Patten, S.B.; Patton, G.C.; Paulson, K.; Pearce, N.; Pereira, D.M.; Perico, N.; Pesudovs, K.; Peterson, C.B.; Petzold, M.; Phillips, M.R.; Pigott, D.M.; Pillay, J.D.; Pinho, C.; Plass, D.; Pletcher, M.A.; Popova, S.; Poulton, R.G.; Pourmalek, F.; Prabhakaran, D.; Prasad, N.M.; Prasad, N.; Purcell, C.; Qorbani, M.; Quansah, R.; Quintanilla, B.P.A.; Rabiee, R.H.S.; Radfar, A.; Rafay, A.; Rahimi, K.; Rahimi-Movaghar, A.; Rahimi-Movaghar, V.; Rahman, M.H.U.; Rahman, M.; Rai, R.K.; Rajsic, S.; Ram, U.; Ranabhat, C.L.; Rankin, Z.; Rao, P.C.; Rao, P.V.; Rawaf, S.; Ray, S.E.; Reiner, R.C.; Reinig, N.; Reitsma, M.B.; Remuzzi, G.; Renzaho, A.M.N.; Resnikoff, S.; Rezaei, S.; Ribeiro, A.L.; Ronfani, L.; Roshandel, G.; Roth, G.A.; Roy, A.; Rubagotti, E.; Ruhago, G.M.; Saadat, S.; Sadat, N.; Safdarian, M.; Safi, S.; Safiri, S.; Sagar, R.; Sahathevan, R.; Salama, J.; Saleem, H.O.B.; Salomon, J.A.; Salvi, S.S.; Samy, A.M.; Sanabria, J.R.; Santomauro, D.; Santos, I.S.; Santos, J.V.; Santric Milicevic, M.M.; Sartorius, B.; Satpathy, M.; Sawhney, M.; Saxena, S.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schwebel, D.C.; Schwendicke, F.; Seedat, S.; Sepanlou, S.G.; Servan-Mori, E.E.; Setegn, T.; Shackelford, K.A.; Shaheen, A.; Shaikh, M.A.; Shamsipour, M.; Shariful Islam, S.M.; Sharma, J.; Sharma, R.; She, J.; Shi, P.; Shields, C.; Shifa, G.T.; Shigematsu, M.; Shinohara, Y.; Shiri, R.; Shirkoohi, R.; Shirude, S.; Shishani, K.; Shrime, M.G.; Sibai, A.M.; Sigfusdottir, I.D.; Silva, D.A.S.; Silva, J.P.; Silveira, D.G.A.; Singh, J.A.; Singh, N.P.; Sinha, D.N.; Skiadaresi, E.; Skirbekk, V.; Slepak, E.L.; Sligar, A.; Smith, D.L.; Smith, M.; Sobaih, B.H.A.; Sobngwi, E.; Sorensen, R.J.D.; Sousa, T.C.M.; Sposato, L.A.; Sreeramareddy, C.T.; Srinivasan, V.; Stanaway, J.D.; Stathopoulou, V.; Steel, N.; Stein, M.B.; Stein, D.J.; Steiner, T.J.; Steiner, C.; Steinke, S.; Stokes, M.A.; Stovner, L.J.; Strub, B.; Subart, M.; Sufiyan, M.B.; Sunguya, B.F.; Sur, P.J.; Swaminathan, S.; Sykes, B.L.; Sylte, D.O.; Tabarés-Seisdedos, R.; Taffere, G.R.; Takala, J.S.; Tandon, N.; Tavakkoli, M.; Taveira, N.; Taylor, H.R.; Tehrani-Banihashemi, A.; Tekelab, T.; Terkawi, A.S.; Tesfaye, D.J.; Tesssema, B.; Thamsuwan, O.; Thomas, K.E.; Thrift, A.G.; Tiruye, T.Y.; Tobe-Gai, R.; Tollanes, M.C.; Tonelli, M.; Topor-Madry, R.; Tortajada, M.; Touvier, M.; Tran, B.X.; Tripathi, S.; Troeger, C.; Truelsen, T.; Tsoi, D.; Tuem, K.B.; Tuzcu, E.M.; Tyrovolas, S.; Ukwaja, K.N.; Undurraga, E.A.; Uneke, C.J.; Updike, R.; Uthman, O.A.; Uzochukwu, B.S.C.; van Boven, J.F.M.; Varughese, S.; Vasankari, T.; Venkatesh, S.; Venketasubramanian, N.; Vidavalur, R.; Violante, F.S.; Vladimirov, S.K.; Vlassov, V.V.; Vollset, S.E.; Wadilo, F.; Wakayo, T.; Wang, Y-P.; Weaver, M.; Weichenthal, S.; Weiderpass, E.; Weintraub, R.G.; Werdecker, A.; Westerman, R.; Whiteford, H.A.; Wijeratne, T.; Wiysonge, C.S.; Wolfe, C.D.A.; Woodbrook, R.; Woolf, A.D.; Workicho, A.; Xavier, D.; Xu, G.; Yadgir, S.; Yaghoubi, M.; Yakob, B.; Yan, L.L.; Yano, Y.; Ye, P.; Yimam, H.H.; Yip, P.; Yonemoto, N.; Yoon, S-J.; Yotebieng, M.; Younis, M.Z.; Zaidi, Z.; Zaki, M.E.S.; Zegeye, E.A.; Zenebe, Z.M.; Zhang, X.; Zhou, M.; Zipkin, B.; Zodpey, S.; Zuhlke, L.J.; Murray, C.J.L. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100), 1211-1259.
[http://dx.doi.org/10.1016/S0140-6736(17)32154-2] [PMID: 28919117]
[16]
Zhao, C.; Deng, W.; Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 2008, 132(4), 645-660.
[http://dx.doi.org/10.1016/j.cell.2008.01.033] [PMID: 18295581]
[17]
Murray, C.J.L.; Atkinson, C.; Bhalla, K.; Birbeck, G.; Burstein, R.; Chou, D.; Dellavalle, R.; Danaei, G.; Ezzati, M.; Fahimi, A.; Flaxman, D. Foreman; Gabriel, S.; Gakidou, E.; Kassebaum, N.; Khatibzadeh, S.; Lim, S.; Lipshultz, S.E.; London, S.; Lopez; MacIntyre, M.F.; Mokdad, A.H.; Moran, A.; Moran, A.E.; Mozaffarian, D.; Murphy, T.; Naghavi, M.; Pope, C.; Roberts, T.; Salomon, J.; Schwebel, D.C.; Shahraz, S.; Sleet, D.A.; Murray; Abraham, J.; Ali, M.K.; Atkinson, C.; Bartels, D.H.; Bhalla, K.; Birbeck, G.; Burstein, R.; Chen, H.; Criqui, M.H.; Dahodwala; Jarlais; Ding, E.L.; Dorsey, E.R.; Ebel, B.E.; Ezzati, M.; Fahami; Flaxman, S.; Flaxman, A.D.; Gonzalez-Medina, D.; Grant, B.; Hagan, H.; Hoffman, H.; Kassebaum, N.; Khatibzadeh, S.; Leasher, J.L.; Lin, J.; Lipshultz, S.E.; Lozano, R.; Lu, Y.; Mallinger, L.; McDermott, M.M.; Micha, R.; Miller, T.R.; Mokdad, A.A.; Mokdad, A.H.; Mozaffarian, D.; Naghavi, M.; Narayan, K.M.; Omer, S.B.; Pelizzari, P.M.; Phillips, D.; Ranganathan, D.; Rivara, F.P.; Roberts, T.; Sampson, U.; Sanman, E.; Sapkota, A.; Schwebel, D.C.; Sharaz, S.; Shivakoti, R.; Singh, G.M.; Singh, D.; Tavakkoli, M.; Towbin, J.A.; Wilkinson, J.D.; Zabetian, A.; Murray; Abraham, J.; Ali, M.K.; Alvardo, M.; Atkinson, C.; Baddour, L.M.; Benjamin, E.J.; Bhalla, K.; Birbeck, G.; Bolliger, I.; Burstein, R.; Carnahan, E.; Chou, D.; Chugh, S.S.; Cohen, A.; Colson, K.E.; Cooper, L.T.; Couser, W.; Criqui, M.H.; Dabhadkar, K.C.; Dellavalle, R.P.; Jarlais; Dicker, D.; Dorsey, E.R.; Duber, H.; Ebel, B.E.; Engell, R.E.; Ezzati, M.; Felson, D.T.; Finucane, M.M.; Flaxman, S.; Flaxman, A.D.; Fleming, T.; Foreman; Forouzanfar, M.H.; Freedman, G.; Freeman, M.K.; Gakidou, E.; Gillum, R.F.; Gonzalez-Medina, D.; Gosselin, R.; Gutierrez, H.R.; Hagan, H.; Havmoeller, R.; Hoffman, H.; Jacobsen, K.H.; James, S.L.; Jasrasaria, R.; Jayarman, S.; Johns, N.; Kassebaum, N.; Khatibzadeh, S.; Lan, Q.; Leasher, J.L.; Lim, S.; Lipshultz, S.E.; London, S.; Lopez; Lozano, R.; Lu, Y.; Mallinger, L.; Meltzer, M.; Mensah, G.A.; Michaud, C.; Miller, T.R.; Mock, C.; Moffitt, T.E.; Mokdad, A.A.; Mokdad, A.H.; Moran, A.; Naghavi, M.; Narayan, K.M.; Nelson, R.G.; Olives, C.; Omer, S.B.; Ortblad, K.; Ostro, B.; Pelizzari, P.M.; Phillips, D.; Raju, M.; Razavi, H.; Ritz, B.; Roberts, T.; Sacco, R.L.; Salomon, J.; Sampson, U.; Schwebel, D.C.; Shahraz, S.; Shibuya, K.; Silberberg, D.; Singh, J.A.; Steenland, K.; Taylor, J.A.; Thurston, G.D.; Vavilala, M.S.; Vos, T.; Wagner, G.R.; Weinstock, M.A.; Weisskopf, M.G.; Wulf, S.; Murray, The state of US health, 1990-2010: Burden of diseases, injuries, and risk factors. JAMA, 2013, 310(6), 591-608.
[http://dx.doi.org/10.1001/jama.2013.13805] [PMID: 23842577]
[18]
Barnes, D.E.; Yaffe, K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol., 2011, 10(9), 819-828.
[http://dx.doi.org/10.1016/S1474-4422(11)70072-2] [PMID: 21775213]
[19]
Cummings, J.L. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology, 1997, 48(5)(Suppl. 6), S10-S16.
[http://dx.doi.org/10.1212/WNL.48.5_Suppl_6.10S] [PMID: 9153155]
[20]
Lyketsos, C.G.; Lopez, O.; Jones, B.; Fitzpatrick, A.L.; Breitner, J.; DeKosky, S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 2002, 288(12), 1475-1483.
[http://dx.doi.org/10.1001/jama.288.12.1475] [PMID: 12243634]
[21]
Norton, S.; Matthews, F.E.; Barnes, D.E.; Yaffe, K.; Brayne, C. Potential for primary prevention of Alzheimer’s disease: An analysis of population-based data. Lancet Neurol., 2014, 13(8), 788-794.
[http://dx.doi.org/10.1016/S1474-4422(14)70136-X] [PMID: 25030513]
[22]
McKee, A.C.; Stein, T.D.; Nowinski, C.J.; Stern, R.A.; Daneshvar, D.H.; Alvarez, V.E.; Lee, H.S.; Hall, G.; Wojtowicz, S.M.; Baugh, C.M.; Riley, D.O.; Kubilus, C.A.; Cormier, K.A.; Jacobs, M.A.; Martin, B.R.; Abraham, C.R.; Ikezu, T.; Reichard, R.R.; Wolozin, B.L.; Budson, A.E.; Goldstein, L.E.; Kowall, N.W.; Cantu, R.C. The spectrum of disease in chronic traumatic encephalopathy. Brain, 2013, 136(1), 43-64.
[http://dx.doi.org/10.1093/brain/aws307] [PMID: 23208308]
[23]
Leech, R.; Sharp, D.J. The role of the posterior cingulate cortex in cognition and disease. Brain, 2014, 137(1), 12-32.
[http://dx.doi.org/10.1093/brain/awt162] [PMID: 23869106]
[24]
Niswender, C.M.; Conn, P.J. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu. Rev. Pharmacol. Toxicol., 2010, 50(1), 295-322.
[http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533] [PMID: 20055706]
[25]
Mittal, V.A.; Walker, E.F. Diagnostic and statistical manual of mental disorders. Psychiatry Res., 2011, 1891, 158-159.
[http://dx.doi.org/10.1016/j.psychres.2011.06.006]
[26]
Migliorelli, R.; Tesón, A.; Sabe, L.; Petracchi, M.; Leiguarda, R.; Starkstein, S.E. Prevalence and correlates of dysthymia and major depression among patients with Alzheimer’s disease. Am. J. Psychiatry, 1995, 152(1), 37-44.
[http://dx.doi.org/10.1176/ajp.152.1.37] [PMID: 7802118]
[27]
Mega, M.S.; Cummings, J.L.; Fiorello, T.; Gornbein, J. The spectrum of behavioral changes in Alzheimer’s disease. Neurology, 1996, 46(1), 130-135.
[http://dx.doi.org/10.1212/WNL.46.1.130] [PMID: 8559361]
[28]
Green, R.C.; Cupples, L.A.; Kurz, A.; Auerbach, S.; Go, R.; Sadovnick, D.; Duara, R.; Kukull, W.A.; Chui, H.; Edeki, T.; Griffith, P.A.; Friedland, R.P.; Bachman, D.; Farrer, L. Depression as a risk factor for Alzheimer disease: The MIRAGE Study. Arch. Neurol., 2003, 60(5), 753-759.
[http://dx.doi.org/10.1001/archneur.60.5.753] [PMID: 12756140]
[29]
Ownby, R.L.; Crocco, E.; Acevedo, A.; John, V.; Loewenstein, D. Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis. Arch. Gen. Psychiatry, 2006, 63(5), 530-538.
[http://dx.doi.org/10.1001/archpsyc.63.5.530] [PMID: 16651510]
[30]
Panza, F.; Frisardi, V.; Capurso, C.; D’Introno, A.; Colacicco, A.M.; Imbimbo, B.P.; Santamato, A.; Vendemiale, G.; Seripa, D.; Pilotto, A.; Capurso, A.; Solfrizzi, V. Late-life depression, mild cognitive impairment, and dementia: Possible continuum? Am. J. Geriatr. Psychiatry, 2010, 18(2), 98-116.
[http://dx.doi.org/10.1097/JGP.0b013e3181b0fa13] [PMID: 20104067]
[31]
Saczynski, J.S.; Beiser, A.; Seshadri, S.; Auerbach, S.; Wolf, P.A.; Au, R. Depressive symptoms and risk of dementia. Neurology, 2010, 75(1), 35-41.
[http://dx.doi.org/10.1212/WNL.0b013e3181e62138] [PMID: 20603483]
[32]
McKhann, G.M.; Knopman, D.S.; Chertkow, H.; Hyman, B.T.; Jack, C.R., Jr; Kawas, C.H.; Klunk, W.E.; Koroshetz, W.J.; Manly, J.J.; Mayeux, R.; Mohs, R.C.; Morris, J.C.; Rossor, M.N.; Scheltens, P.; Carrillo, M.C.; Thies, B.; Weintraub, S.; Phelps, C.H. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the national institute on aging‐alzheimer’s association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement., 2011, 7(3), 263-269.
[http://dx.doi.org/10.1016/j.jalz.2011.03.005] [PMID: 21514250]
[33]
Diniz, B.S.; Butters, M.A.; Albert, S.M.; Dew, M.A.; Reynolds, C.F. III Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. Br. J. Psychiatry, 2013, 202(5), 329-335.
[http://dx.doi.org/10.1192/bjp.bp.112.118307] [PMID: 23637108]
[34]
Association, A.P.; Association, A.P. DSM-5 Task Force Diagnostic and statistical manual of mental disorders: DSM-5; American Psychiatric Association: Washington, DC, 2013.
[http://dx.doi.org/10.1176/appi.books.9780890425596]
[35]
Albert, M.S.; DeKosky, S.T.; Dickson, D.; Dubois, B.; Feldman, H.H.; Fox, N.C.; Gamst, A.; Holtzman, D.M.; Jagust, W.J.; Petersen, R.C.; Snyder, P.J.; Carrillo, M.C.; Thies, B.; Phelps, C.H. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging‐Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement., 2011, 7(3), 270-279.
[http://dx.doi.org/10.1016/j.jalz.2011.03.008] [PMID: 21514249]
[36]
Jessen, F.; Amariglio, R.E.; van Boxtel, M.; Breteler, M.; Ceccaldi, M.; Chételat, G.; Dubois, B.; Dufouil, C.; Ellis, K.A.; van der Flier, W.M.; Glodzik, L.; van Harten, A.C.; de Leon, M.J.; McHugh, P.; Mielke, M.M.; Molinuevo, J.L.; Mosconi, L.; Osorio, R.S.; Perrotin, A.; Petersen, R.C.; Rabin, L.A.; Rami, L.; Reisberg, B.; Rentz, D.M.; Sachdev, P.S.; de la Sayette, V.; Saykin, A.J.; Scheltens, P.; Shulman, M.B.; Slavin, M.J.; Sperling, R.A.; Stewart, R.; Uspenskaya, O.; Vellas, B.; Visser, P.J.; Wagner, M. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement., 2014, 10(6), 844-852.
[http://dx.doi.org/10.1016/j.jalz.2014.01.001] [PMID: 24798886]
[37]
Byers, A.L.; Yaffe, K. Depression and risk of developing dementia. Nat. Rev. Neurol., 2011, 7(6), 323-331.
[http://dx.doi.org/10.1038/nrneurol.2011.60] [PMID: 21537355]
[38]
Yaffe, K.; Yaffe, K.; Byers, A.L.; McCormick, M.; Schaefer, C.; Whitmer, R.A. Midlife vs. late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia. Arch. Gen. Psychiatry, 2012, 69(5), 493-498.
[http://dx.doi.org/10.1001/archgenpsychiatry.2011.1481] [PMID: 22566581]
[39]
Sperling, R.A.; Aisen, P.S.; Beckett, L.A.; Bennett, D.A.; Craft, S.; Fagan, A.M. Toward defining the preclinical stages of Alzheimer’s disease: Recomme ndations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement., 2011, 7(3), 280-292.
[http://dx.doi.org/10.1016/j.jalz.2011.03.003]
[40]
Livingston, G.; Huntley, J.; Sommerlad, A.; Ames, D.; Ballard, C.; Banerjee, S. Dementia prevention, intervention, and care: 2020 report of the lancet commission. Lancet, 2020, 396(10248), 413-446.
[http://dx.doi.org/10.1016/S0140-6736(20)30367-6]
[41]
Jack, C.R., Jr; Bennett, D.A.; Blennow, K.; Carrillo, M.C.; Dunn, B.; Haeberlein, S.B.; Holtzman, D.M.; Jagust, W.; Jessen, F.; Karlawish, J.; Liu, E.; Molinuevo, J.L.; Montine, T.; Phelps, C.; Rankin, K.P.; Rowe, C.C.; Scheltens, P.; Siemers, E.; Snyder, H.M.; Sperling, R.; Elliott, C.; Masliah, E.; Ryan, L.; Silverberg, N. NIA‐AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement., 2018, 14(4), 535-562.
[http://dx.doi.org/10.1016/j.jalz.2018.02.018] [PMID: 29653606]
[42]
Livingston, G.; Sommerlad, A.; Orgeta, V.; Costafreda, S.G.; Huntley, J.; Ames, D.; Ballard, C.; Banerjee, S.; Burns, A.; Cohen-Mansfield, J.; Cooper, C.; Fox, N.; Gitlin, L.N.; Howard, R.; Kales, H.C.; Larson, E.B.; Ritchie, K.; Rockwood, K.; Sampson, E.L.; Samus, Q.; Schneider, L.S.; Selbæk, G.; Teri, L.; Mukadam, N. Dementia prevention, intervention, and care. Lancet, 2017, 390(10113), 2673-2734.
[http://dx.doi.org/10.1016/S0140-6736(17)31363-6] [PMID: 28735855]
[43]
Alzheimer’s, A. Alzheimer’s disease facts and figures. Alzheimer’s &amp. Dementia, 2018, 14(3), 367-429.
[http://dx.doi.org/10.1016/j.jalz.2018.02.001]
[44]
Zhao, Q.F.; Tan, L.; Wang, H.F.; Jiang, T.; Tan, M.S.; Tan, L.; Xu, W.; Li, J.Q.; Wang, J.; Lai, T.J.; Yu, J.T. The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: Systematic review and meta-analysis. J. Affect. Disord., 2016, 190, 264-271.
[http://dx.doi.org/10.1016/j.jad.2015.09.069] [PMID: 26540080]
[45]
Jessen, F.; Amariglio, R.E.; Buckley, R.F.; van der Flier, W.M.; Han, Y.; Molinuevo, J.L.; Rabin, L.; Rentz, D.M.; Rodriguez-Gomez, O.; Saykin, A.J.; Sikkes, S.A.M.; Smart, C.M.; Wolfsgruber, S.; Wagner, M. The characterisation of subjective cognitive decline. Lancet Neurol., 2020, 19(3), 271-278.
[http://dx.doi.org/10.1016/S1474-4422(19)30368-0] [PMID: 31958406]
[46]
Selkoe, D.J.; Hardy, J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol. Med., 2016, 8(6), 595-608.
[http://dx.doi.org/10.15252/emmm.201606210] [PMID: 27025652]
[47]
Donovan, N.J.; Locascio, J.J.; Marshall, G.A.; Gatchel, J.; Hanseeuw, B.J.; Rentz, D.M. Longitudinal association of amyloid beta and anxious-depressive sympto ms in cognitively normal older adults. Am. J. Psychiatry, 2017, 175(6), 530-537.
[http://dx.doi.org/10.1176/appi.ajp.2017.17040442]
[48]
Kokol, P.; Kokol, M.; Zagoranski, S. Machine learning on small size samples: A synthetic knowledge synthesis. Sci. Prog., 2022, 105(1)
[http://dx.doi.org/10.1177/00368504211029777] [PMID: 35220816]
[49]
Chen, B.; Fu, Y.; Song, G.; Zhong, W.; Guo, J. Research trends and hotspots of exercise for Alzheimer’s disease: A bibliometric analysis. Front. Aging Neurosci., 2022, 14, 984705.
[http://dx.doi.org/10.3389/fnagi.2022.984705] [PMID: 36158544]
[50]
Bao, X.; Xu, J.; Meng, Q.; Gan, J.; Wang, X.D.; Wu, H.; Liu, S.; Ji, Y. Impact of the COVID-19 pandemic and lockdown on anxiety, depression and nursing burden of caregivers in alzheimer’s disease, dementia with lewy bodies and mild cognitive impairment in China: A 1-Year follow-up study. Front. Psychiatry, 2022, 13, 921535.
[http://dx.doi.org/10.3389/fpsyt.2022.921535] [PMID: 35873235]
[51]
Norton, M.C.; Clark, C.; Fauth, E.B.; Piercy, K.W.; Pfister, R.; Green, R.C.; Corcoran, C.D.; Rabins, P.V.; Lyketsos, C.G.; Tschanz, J.T. Caregiver personality predicts rate of cognitive decline in a community sample of persons with Alzheimer’s disease. The Cache County Dementia Progression Study. Int. Psychogeriatr., 2013, 25(10), 1629-1637.
[http://dx.doi.org/10.1017/S1041610213001105] [PMID: 23830578]
[52]
Peters, M.E.; Rosenberg, P.B.; Steinberg, M.; Norton, M.C.; Welsh-Bohmer, K.A.; Hayden, K.M.; Breitner, J.; Tschanz, J.T.; Lyketsos, C.G. Neuropsychiatric symptoms as risk factors for progression from CIND to dementia: the Cache County Study. Am. J. Geriatr. Psychiatry, 2013, 21(11), 1116-1124.
[http://dx.doi.org/10.1016/j.jagp.2013.01.049] [PMID: 23567370]
[53]
Chan, C.K.; Sieber, F.E.; Blennow, K.; Inouye, S.K.; Kahn, G.; Leoutsakos, J.M.S.; Marcantonio, E.R.; Neufeld, K.J.; Rosenberg, P.B.; Wang, N.Y.; Zetterberg, H.; Lyketsos, C.G.; Oh, E.S. Association of depressive symptoms with postoperative delirium and CSF biomarkers for alzheimer’s disease among hip fracture patients. Am. J. Geriatr. Psychiatry, 2021, 29(12), 1212-1221.
[http://dx.doi.org/10.1016/j.jagp.2021.02.001] [PMID: 33640268]
[54]
Kim, A.S.; Garcia Morales, E.E.; Amjad, H.; Cotter, V.T.; Lin, F.R.; Lyketsos, C.G.; Nowrangi, M.A.; Mamo, S.K.; Reed, N.S.; Yasar, S.; Oh, E.S.; Nieman, C.L. Association of hearing loss with neuropsychiatric symptoms in older adults with cognitive impairment. Am. J. Geriatr. Psychiatry, 2021, 29(6), 544-553.
[http://dx.doi.org/10.1016/j.jagp.2020.10.002] [PMID: 33168388]
[55]
Marshall, G.A.; Monserratt, L.; Harwood, D.; Mandelkern, M.; Cummings, J.L.; Sultzer, D.L. Positron emission tomography metabolic correlates of apathy in Alzheimer disease. Arch. Neurol., 2007, 64(7), 1015-1020.
[http://dx.doi.org/10.1001/archneur.64.7.1015] [PMID: 17620493]
[56]
Teng, E.; Lu, P.H.; Cummings, J.L. Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer’s disease. Dement. Geriatr. Cogn. Disord., 2007, 24(4), 253-259.
[http://dx.doi.org/10.1159/000107100] [PMID: 17700021]
[57]
Chen, C.; Song, M. Visualizing a field of research: A methodology of systematic scientometric reviews. PLoS One, 2019, 14(10), e0223994.
[http://dx.doi.org/10.1371/journal.pone.0223994] [PMID: 31671124]
[58]
Gupta, R.; Advani, D.; Yadav, D.; Ambasta, R.K.; Kumar, P. Dissecting the relationship between neuropsychiatric and neurodegenerative disorders. Mol. Neurobiol., 2023, 60(11), 6476-6529.
[http://dx.doi.org/10.1007/s12035-023-03502-9] [PMID: 37458987]
[59]
Serrano-Pozo, A.; Aldridge, G.M.; Zhang, Q.; Sorensen, A. Four decades of research in Alzheimer’s disease (1975-2014): A bibliometric and scientometric analysis. J. Alzheimers Dis., 2017, 59(2), 763-783.
[http://dx.doi.org/10.3233/JAD-170184] [PMID: 28671119]
[60]
Patel, H.; Dobson, R.J.B.; Newhouse, S.J. A meta-analysis of alzheimer’s disease brain transcriptomic data. J. Alzheimers Dis., 2019, 68(4), 1635-1656.
[http://dx.doi.org/10.3233/JAD-181085] [PMID: 30909231]
[61]
Huang, Y.; Wu, J.; Zhang, H.; Li, Y.; Wen, L.; Tan, X.; Cheng, K.; Liu, Y.; Pu, J.; Liu, L.; Wang, H.; Li, W.; Perry, S.W.; Wong, M.L.; Licinio, J.; Zheng, P.; Xie, P. The gut microbiome modulates the transformation of microglial subtypes. Mol. Psychiatry, 2023, 28(4), 1611-1621.
[http://dx.doi.org/10.1038/s41380-023-02017-y] [PMID: 36914812]
[62]
Végh, M.J.; Heldring, C.M.; Kamphuis, W.; Hijazi, S.; Timmerman, A.J.; Li, K.W.; van Nierop, P.; Mansvelder, H.D.; Hol, E.M.; Smit, A.B.; van Kesteren, R.E. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease. Acta Neuropathol. Commun., 2014, 2(1), 76.
[http://dx.doi.org/10.1186/s40478-014-0076-z] [PMID: 24974208]
[63]
Mayordomo-Cava, J.; Iborra-Lázaro, G.; Djebari, S.; Temprano-Carazo, S.; Sánchez-Rodríguez, I.; Jeremic, D.; Gruart, A.; Delgado-García, J.M.; Jiménez-Díaz, L.; Navarro-López, J.D. Impairments of synaptic plasticity induction threshold and network oscillatory activity in the hippocampus underlie memory deficits in a non-transgenic mouse model of amyloidosis. Biology, 2020, 9(7), 175.
[http://dx.doi.org/10.3390/biology9070175] [PMID: 32698467]
[64]
Tang, W.; Wang, Y.; Cheng, J.; Yao, J.; Yao, Y.Y.; Zhou, Q.; Guan, S.H. CSF sAPPα and sAPPβ levels in Alzheimer’s disease and multiple other neurodegenerative diseases: A network meta-analysis. Neuromolecular Med., 2020, 22(1), 45-55.
[http://dx.doi.org/10.1007/s12017-019-08561-7] [PMID: 31414383]
[65]
Golas, A.C.; Salwierz, P.; Rajji, T.K.; Bowie, C.R.; Butters, M.A.; Fischer, C.E.; Flint, A.J.; Herrmann, N.; Mah, L.; Mulsant, B.H.; Pollock, B.G.; Taghdiri, F.; Wang, W.; Tartaglia, M.C. Assessing the role of past depression in patients with mild cognitive impairment, with and without biomarkers for Alzheimer’s disease. J. Alzheimers Dis., 2023, 92(4), 1219-1227.
[http://dx.doi.org/10.3233/JAD-221097] [PMID: 36911939]
[66]
Chen, D.; Huang, C.; Chen, Z. A review for the pharmacological effect of lycopene in central nervous system disorders. Biomed. Pharmacother., 2019, 111, 791-801.
[http://dx.doi.org/10.1016/j.biopha.2018.12.151] [PMID: 30616078]
[67]
Dillon, K.; Morava, A.; Prapavessis, H.; Grigsby-Duffy, L.; Novic, A.; Gardiner, P.A. Total sedentary time and cognitive function in middle-aged and older adults: A systematic review and meta-analysis. Sports Med. Open, 2022, 8(1), 127.
[http://dx.doi.org/10.1186/s40798-022-00507-x] [PMID: 36224459]
[68]
Taljaard, D.S.; Olaithe, M.; Brennan-Jones, C.G.; Eikelboom, R.H.; Bucks, R.S. The relationship between hearing impairment and cognitive function: A meta‐analysis in adults. Clin. Otolaryngol., 2016, 41(6), 718-729.
[http://dx.doi.org/10.1111/coa.12607] [PMID: 26670203]
[69]
Ahn, S.; Mathiason, M.A.; Yu, F. Longitudinal cognitive profiles by anxiety and depressive symptoms in american older adults with subjective cognitive decline. J. Nurs. Scholarsh., 2021, 53(6), 698-708.
[http://dx.doi.org/10.1111/jnu.12692] [PMID: 34342395]
[70]
Wilson, R.S.; Krueger, K.R.; Arnold, S.E.; Schneider, J.A.; Kelly, J.F.; Barnes, L.L.; Tang, Y.; Bennett, D.A. Loneliness and risk of Alzheimer disease. Arch. Gen. Psychiatry, 2007, 64(2), 234-240.
[http://dx.doi.org/10.1001/archpsyc.64.2.234] [PMID: 17283291]
[71]
Bonk, S.; Kirchner, K.; Ameling, S.; Garvert, L.; Völzke, H.; Nauck, M.; Völker, U.; Grabe, H.J.; Van der Auwera, S. APOE ε4 in depression-associated memory impairment-evidence from genetic and microRNA analyses. Biomedicines, 2022, 10(7), 1560.
[http://dx.doi.org/10.3390/biomedicines10071560] [PMID: 35884866]
[72]
MacAulay, R.K.; Halpin, A.; Cohen, A.S.; Calamia, M.; Boeve, A.; Zhang, L.; Brouillette, R.M.; Foil, H.C.; Bruce-Keller, A.; Keller, J.N. Predictors of heterogeneity in cognitive function: APOE-e4, sex, education, depression, and vascular risk. Arch. Clin. Neuropsychol., 2020, 35(6), 660-670.
[http://dx.doi.org/10.1093/arclin/acaa014] [PMID: 32129455]
[73]
Thies, W.; Bleiler, L. 2012 Alzheimer’s disease facts and figures Alzheimer’s association. Alzheimers Dement., 2012, 8(2), 131-168.
[http://dx.doi.org/10.1016/j.jalz.2012.02.001] [PMID: 22404854]
[74]
Cagnin, A.; Di Lorenzo, R.; Marra, C.; Bonanni, L.; Cupidi, C.; Laganà, V.; Rubino, E.; Vacca, A.; Provero, P.; Isella, V.; Vanacore, N.; Agosta, F.; Appollonio, I.; Caffarra, P.; Pettenuzzo, I.; Sambati, R.; Quaranta, D.; Guglielmi, V.; Logroscino, G.; Filippi, M.; Tedeschi, G.; Ferrarese, C.; Rainero, I.; Bruni, A.C. Behavioral and psychological effects of coronavirus disease-19 quarantine in patients with dementia. Front. Psychiatry, 2020, 11, 578015.
[http://dx.doi.org/10.3389/fpsyt.2020.578015] [PMID: 33033486]
[75]
Tapia Muñoz, T.; Slachevsky, A.; León-Campos, M.O.; Madrid, M.; Caqueo-Urízar, A.; Rohde, G.C.; Miranda-Castillo, C. Predictors of unmet needs in Chilean older people with dementia: A cross-sectional study. BMC Geriatr., 2019, 19(1), 106.
[http://dx.doi.org/10.1186/s12877-019-1131-1] [PMID: 30987587]
[76]
Figueiro, M.G.; Plitnick, B.; Roohan, C.; Sahin, L.; Kalsher, M.; Rea, M.S. Effects of a tailored lighting intervention on sleep quality, rest-activity, mood, and behavior in older adults with Alzheimer disease and related dementias: A randomized clinical trial. J. Clin. Sleep Med., 2019, 15(12), 1757-1767.
[http://dx.doi.org/10.5664/jcsm.8078] [PMID: 31855161]
[77]
Bárrios, H.; Verdelho, A.; Narciso, S.; Gonçalves-Pereira, M.; Logsdon, R.; de Mendonça, A. Quality of life in patients with cognitive impairment: Validation of the quality of life-Alzheimer’s disease scale in portugal. Int. Psychogeriatr., 2013, 25(7), 1085-1096.
[http://dx.doi.org/10.1017/S1041610213000379] [PMID: 23534370]
[78]
Ahn, S.; Mathiason, M.A.; Lindquist, R.; Yu, F. Factors predicting episodic memory changes in older adults with subjective cognitive decline: A longitudinal observational study. Geriatr. Nurs., 2021, 42(1), 268-275.
[http://dx.doi.org/10.1016/j.gerinurse.2020.08.016] [PMID: 32919799]
[79]
Mavounza, C.; Ouellet, M.C.; Hudon, C. Caregivers’ emotional distress due to neuropsychiatric symptoms of persons with amnestic mild cognitive impairment or Alzheimer’s disease. Aging Ment. Health, 2020, 24(3), 423-430.
[http://dx.doi.org/10.1080/13607863.2018.1544208] [PMID: 30588847]
[80]
Rosenberg, P.B.; Mielke, M.M.; Appleby, B.S.; Oh, E.S.; Geda, Y.E.; Lyketsos, C.G. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am. J. Geriatr. Psychiatry, 2013, 21(7), 685-695.
[http://dx.doi.org/10.1016/j.jagp.2013.01.006] [PMID: 23567400]
[81]
Azocar, I.; Rapaport, P.; Burton, A.; Meisel, G.; Orgeta, V. Risk factors for apathy in Alzheimer’s disease: A systematic review of longitudinal evidence. Ageing Res. Rev., 2022, 79, 101672.
[http://dx.doi.org/10.1016/j.arr.2022.101672]
[82]
Tanaka, H.; Hashimoto, M.; Fukuhara, R.; Ishikawa, T.; Yatabe, Y.; Kaneda, K.; Yuuki, S.; Honda, K.; Matsuzaki, S.; Tsuyuguchi, A.; Hatada, Y.; Ikeda, M. Relationship between dementia severity and behavioural and psychological symptoms in early‐onset Alzheimer’s disease. Psychogeriatrics, 2015, 15(4), 242-247.
[http://dx.doi.org/10.1111/psyg.12108] [PMID: 25737233]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version258msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[17:52:48] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[17:52:48] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[17:52:48] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[17:52:48] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[17:52:48] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (92.01ms)time
  • Application (166ms)time
  • 1 x Application (64.4%)
    166ms
    1 x Booting (35.6%)
    92.01ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    31 statements were executed, 4 of which were duplicates, 27 unique. Show only duplicated94.73ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51435153','',1,1739987568,1739987568) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739987568
      1msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51435153','/article/142007',1,1739987568,1739987568)
      180μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51435153 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51435153) limit 1
      12.72msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51435153
      • 1: 51435153
      • 2: 51435153
      • 3: 51435153
      • 4: 51435153
      • 5: 51435153
      • 6: 51435153
      • 7: 51435153
      • 8: 51435153
      • 9: 51435153
      • 10: 51435153
      • 11: 51435153
      • 12: 51435153
      • 13: 51435153
      • 14: 51435153
      • 15: 51435153
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=142007
      650μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 26 limit 1
      750μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 26
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and sj.journal_id!=26 group by `j`.`nid`) as `aggregate_table`
      960μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and sj.journal_id!=26 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      810μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.38msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=26) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.3msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '142007'
      200μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 142007
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '142007'
      3.77msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 142007
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '142007' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.2msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 142007
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      270μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      590μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 26 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      33.39msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 26 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      13.4msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 26 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      8.94msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 142007 limit 1
      240μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 142007
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 142007 and content_type = 'article' order by status desc limit 1
      310μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 232467 limit 1
      270μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 232467
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      270μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CN' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      300μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CN
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '142007' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      420μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3461' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      350μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3461) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3461) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51435153 and j.to_ip >=51435153 )) and ((j.from_date <= 1739987568 and j.to_date >= 1739987568 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3461)
      3.48msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      210μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      280μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 142007 limit 1
      3.21msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 142007
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 26 and `b`.`banner_from_date` <= 1739987568 and `b`.`banner_to_date` >= 1739987568 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.37msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 26
      • 3: 1739987568
      • 4: 1739987568
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 26 and `b`.`banner_from_date` <= 1739987568 and `b`.`banner_to_date` >= 1739987568 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.27msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 26
      • 3: 1739987568
      • 4: 1739987568
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='d7e3aed32a481314073ce6642144694c'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        60MBTTLQ8wMamfG80wWtjAGJUyTG2RXJPfIPZR9X
        uc_cart_id
        d7e3aed32a481314073ce6642144694c
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/142007" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/142007
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 17:52:48 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImxxcDlvS203S3JmTmI3UlhNWExnWnc9PSIsInZhbHVlIjoiYlVWV0F3VW81R2JreVNEOFk5dWJjWVgrTzlOcVY1MjVyT3U2a0ROaU1seEthVHpnUzk1aVJ0emR4MU1iUHdkRlBwOVZnbGVhMjN2YnUvZVBtalZVUVBIbzNLVnRPSm1PclgzUW52REc5NThoSytRVHBIWTkvMkpLWnBFK1l0Qm0iLCJtYWMiOiJiYzlhYmVlOGZhOWYxM2Y5NTcyYjkxYTE0ZTkyYjVlNzM4OGQ1ZGUwMDFhYmIwY2FhNjY2NGI4ZmUyZjk1ZDQzIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 05:52:48 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImxxcDlvS203S3JmTmI3UlhNWExnWnc9PSIsInZhbHVlIjoiYlVWV0F3VW81R2JreVNEOFk5dWJjWVgrTzlOcVY1MjVyT3U2a0ROaU1seEthVHpnUzk1aVJ0emR4MU1iUHdkRlBwOVZnb" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikt6K0dIdHdVUjVGQ0psUlpvRXZIeGc9PSIsInZhbHVlIjoiODA4OWM4VDlWbngzWjUydnpIQ0JCWG4wZ0J0YVBkbzIwbG5nSTJwK3NGK2U1Ym12YmNPUEFtNEc4Nko1UHArM2tiUkhOdUloQVl6MURUZDZhT0pCUDRnUGpGdTlTelYxZXBSVHVVY281TjgyQXBEdTZHSnhNMEdYcGVPYk9nUHEiLCJtYWMiOiI1YWM0MTBjYjdjYTc5Y2NhMWQxMTgyNGEzNWY4N2RmZTY3NDE5MTNjZTI1YThiMmYxYzNhNTlmODM3ZjlmNWJiIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ikt6K0dIdHdVUjVGQ0psUlpvRXZIeGc9PSIsInZhbHVlIjoiODA4OWM4VDlWbngzWjUydnpIQ0JCWG4wZ0J0YVBkbzIwbG5nSTJwK3NGK2U1Ym12YmNPUEFtNEc" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImxxcDlvS203S3JmTmI3UlhNWExnWnc9PSIsInZhbHVlIjoiYlVWV0F3VW81R2JreVNEOFk5dWJjWVgrTzlOcVY1MjVyT3U2a0ROaU1seEthVHpnUzk1aVJ0emR4MU1iUHdkRlBwOVZnbGVhMjN2YnUvZVBtalZVUVBIbzNLVnRPSm1PclgzUW52REc5NThoSytRVHBIWTkvMkpLWnBFK1l0Qm0iLCJtYWMiOiJiYzlhYmVlOGZhOWYxM2Y5NTcyYjkxYTE0ZTkyYjVlNzM4OGQ1ZGUwMDFhYmIwY2FhNjY2NGI4ZmUyZjk1ZDQzIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 05:52:48 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImxxcDlvS203S3JmTmI3UlhNWExnWnc9PSIsInZhbHVlIjoiYlVWV0F3VW81R2JreVNEOFk5dWJjWVgrTzlOcVY1MjVyT3U2a0ROaU1seEthVHpnUzk1aVJ0emR4MU1iUHdkRlBwOVZnb" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ikt6K0dIdHdVUjVGQ0psUlpvRXZIeGc9PSIsInZhbHVlIjoiODA4OWM4VDlWbngzWjUydnpIQ0JCWG4wZ0J0YVBkbzIwbG5nSTJwK3NGK2U1Ym12YmNPUEFtNEc4Nko1UHArM2tiUkhOdUloQVl6MURUZDZhT0pCUDRnUGpGdTlTelYxZXBSVHVVY281TjgyQXBEdTZHSnhNMEdYcGVPYk9nUHEiLCJtYWMiOiI1YWM0MTBjYjdjYTc5Y2NhMWQxMTgyNGEzNWY4N2RmZTY3NDE5MTNjZTI1YThiMmYxYzNhNTlmODM3ZjlmNWJiIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ikt6K0dIdHdVUjVGQ0psUlpvRXZIeGc9PSIsInZhbHVlIjoiODA4OWM4VDlWbngzWjUydnpIQ0JCWG4wZ0J0YVBkbzIwbG5nSTJwK3NGK2U1Ym12YmNPUEFtNEc" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "60MBTTLQ8wMamfG80wWtjAGJUyTG2RXJPfIPZR9X" "uc_cart_id" => "d7e3aed32a481314073ce6642144694c" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/142007" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 17:52:48GET/article/142007514311