Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells

Title:Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells

Volume: 24

Author(s): Lin Zhang, Shuxian Guo, ShuYing Chang and Guan Jiang*

Affiliation:

• Department of Dermatology Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China

Abstract: Oncolytic Viruses (OVs) have emerged as a promising treatment option for cancer thanks to their significant research potential and encouraging results. These viruses exert a profound impact on the tumor microenvironment, making them effective against various types of cancer. In contrast, the efficacy of Chimeric antigen receptor (CAR)-T cell therapy in treating solid tumors is relatively low. The combination of OVs and CAR-T cell therapy, however, is a promising area of research. OVs play a crucial role in enhancing the tumor-suppressive microenvironment, which in turn enables CAR-T cells to function efficiently in the context of solid malignancies. This review aims to provide a comprehensive analysis of the benefits and drawbacks of OV therapy and CAR-T cell therapy, with a focus on the potential of combining these two treatment approaches.

Cite this article as:

Zhang Lin, Guo Shuxian, Chang ShuYing and Jiang Guan*, Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells, Anti-Cancer Agents in Medicinal Chemistry 2024; 24 () . https://dx.doi.org/10.2174/0118715206308253240723055019