Synthesis of Various Spiro-Pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst

Reyhaneh      Nadernia; Ghasem      Marandi; Nourallah      Hazeri; Malek Taher      Maghsoodlou

doi:10.2174/0122115447320104240624045243

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Abstract

Introduction: The present study aims to discuss the synthesis of various spiropyrano- oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid source in the presence of vitamin B12.

Materials and Methods: Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole, resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12.

Results: The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole derivatives. All synthesized compounds closely match previously reported compounds.

Conclusion: In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole has been demonstrated using vitamin B12 as a biocatalyst.

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DOI https://dx.doi.org/10.2174/0122115447320104240624045243	Print ISSN 2211-5447
Publisher Name Bentham Science Publisher	Online ISSN 2211-5455

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Synthesis of Various Spiro-Pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst

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