The Landscape of microRNAs in Bone Tumor: A Comprehensive Review in Recent Studies

Title:The Landscape of microRNAs in Bone Tumor: A Comprehensive Review in Recent Studies

Volume: 13

Author(s): Ramin Raoufinia, Parisa Afrasiabi, Amir Dehghanpour, Sara Memarpour, Sayyed Hadi Sayyed Hosseinian, Ehsan Saburi, Karim Naghipoor, Samaneh Rezaei, Meisam Haghmoradi, Neda Keyhanvar, Mehdi Rostami, Farhad Fakoor, Mohammadali Izadpanah Kazemi, Meysam Moghbeli and Hamid reza Rahimi*

Affiliation:

• Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract: Cancer, the second greatest cause of mortality worldwide, frequently causes bone me-tastases in patients with advanced-stage carcinomas such as prostate, breast, and lung cancer. The existence of these metastases contributes to the occurrence of skeletal-related events (SREs), which are defined by excessive pain, pathological fractures, hypercalcemia, and spinal cord com-pression. These injurious incidents leave uncomfortably large holes in each of the cancer patient’s life quality. Primary bone cancers, including osteosarcoma (OS), chondrosarcoma (CS), and Ewing's sarcoma (ES), have unclear origins. MicroRNA (miRNA) expression patterns have been changed in primary bone cancers such as OS, CS, and ES, indicating a role in tumor development, invasion, metastasis, and treatment response. These miRNAs are persistent in circulation and ex-hibit distinct patterns in many forms of bone tumors, making them potential biomarkers for early detection and treatment of such diseases. Given their crucial regulatory functions in various bio-logical processes and conditions, including cancer, this study aims to look at miRNAs' activities and possible contributions to bone malignancies, focusing on OS, CS, and ES. In conclusion, miRNAs are valuable tools for diagnosing, monitoring, and predicting OS, CS, and ES outcomes. Further research is required to fully comprehend the intricate involvement of miRNAs in these bone cancers and to develop effective miRNA-based treatments.

Cite this article as:

Raoufinia Ramin, Afrasiabi Parisa, Dehghanpour Amir, Memarpour Sara, Sayyed Hosseinian Sayyed Hadi, Saburi Ehsan, Naghipoor Karim, Rezaei Samaneh, Haghmoradi Meisam, Keyhanvar Neda, Rostami Mehdi, Fakoor Farhad, Izadpanah Kazemi Mohammadali, Moghbeli Meysam and Rahimi Hamid reza*, The Landscape of microRNAs in Bone Tumor: A Comprehensive Review in Recent Studies, MicroRNA 2024; 13 () . https://dx.doi.org/10.2174/0122115366298799240625115843