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Abstract
Objective: A detectable innovative fluorimetric method was used to determine OMC in human plasma matrices, pharmaceutical tablets, and vials with high recovery rates and without biological interference.
Method: The fluorimetric technique was used based on the interaction between 4-chloro7-nitrobenzofurazan (NBD-Cl) with a (2-ry amine group) in OMC with pH 8.0, which generates a fluorescent compound measured at 530 nm (exci 470 nm) following a 10-minute heating step at 80 oC. The plasma and milk samples were treated with ammonium sulfate as a salting-out procedure. Results: Omadacycline (OMC) was successfully determined in pharmaceutical, plasma, and milk samples with a linear range from 60.0 to 700.0 ng mL-1, with the lower limit of detection (LOD 5.18 ng mL-1) and limit of quantitation (LOQ 15.72 ng mL-1). Conclusion: This simple, reliable, and detectable fluorimetric method was successfully developed to determine omadacycline in pharmaceutical tablets, plasma samples, and milk with high recovery rates.Related Journals
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