Characterization of Carbamide Peroxide: Stability Studies, and Degradation Kinetics under Isothermal Conditions for Industrial Application

Title:Characterization of Carbamide Peroxide: Stability Studies, and Degradation Kinetics under Isothermal Conditions for Industrial Application

Volume: 20

Author(s): Fabiana Vieira Lima Solino Pessoa*, Rafael Nicolay Pereira, Cassiana Mendes and Marcos Antonio Segatto Silva

Affiliation:

• Post Graduation Program in Pharmaceutical Sciences, Federal University of Santa Catarina, Florianopolis, Brazil
• Department of Health Science, Federal University of Espirito Santo, São Mateus, Brazil

Abstract:

Background: Carbamide peroxide (CP) is a hydrogen peroxide derivative bonded with urea. It is asolid substitute for liquid hydrogen peroxide in the chemical, cosmetics, and pharmaceutical industries, mainly as a disinfectant and bleaching application. However, it has an unstable nature, and there are scant studies on CP thermal analysis.

Objective: This study focuses on CP thermal analysis and degradation behavior.

Methods: CP was characterized by differential scanning calorimetry, thermogravimetric analysis, Fourier-transformed infrared, diffraction by X-ray, as well as, thermal and photodegradation was determined by ultraviolet spectrophotometer.

Results: CP was characterized with a sharp endothermic event (88.50 oC; ΔH= -643.20 J.g-1), and a thermal decomposition behavior in a four-steps process. The pattern diffraction presented sharp peaks at 2θ: 15.2, 25.1 and 26.0o . The Arrhenius plot obtained by isothermal thermogravimetric analysis showed a linear relation with temperature in two steps. The first step the activation energy values was Ea = 45.73 J.mol-1.K-1. The thermal degradation recovery was 3.29% after 5 days, and 11.31% against 97.4% under the dark control to photostability.

Conclusion: The study contributed to characterizing the CP and the results suggest that degradation depends on the surface transition state and the ternary formed system (CP-urea-water) and that the temperature influenced this system. The data were obtained through quick and easy techniques, which use wispy raw material and presented a significant result that can be used by the entire industry in the development of new formulations.

Cite this article as:

Pessoa Vieira Lima Solino Fabiana*, Pereira Nicolay Rafael, Mendes Cassiana and Silva Antonio Segatto Marcos, Characterization of Carbamide Peroxide: Stability Studies, and Degradation Kinetics under Isothermal Conditions for Industrial Application, Current Pharmaceutical Analysis 2024; 20 () . https://dx.doi.org/10.2174/0115734129305540240702114124