Identification of Vascular Genes Differentially Expressed in the Brain of Patients with Alzheimer's Disease

Title:Identification of Vascular Genes Differentially Expressed in the Brain of Patients with Alzheimer's Disease

Volume: 22

Author(s): Kevins Jara-Medina, Luis Lillo, Constanza Lagunas, Gerardo Cabello-Guzmán and Francisco J. Valenzuela-Melgarejo*

Affiliation:

• Department of Basic Sciences, Universidad del BA-o-BA-o, Campus Fernando May, Chillán, Chile. AndrA(c)s Bello 720, Casilla 447 - CP - 3800708

Abstract: Background: Alzheimer's disease (AD) plays a prominent role as the most common form of dementia. Moreover, the traditional mechanism of AD does not explain the microvascular damage observed in about 25-30 years between the onset of AD, which results in late application treatment that inhibits or delays neurodegeneration.

Objective: Our objective was to identify differentially expressed genes in human brain samples associated with vascular disruption in AD.

Methods: We analyzed 1633 post-mortem brain samples in the GEO to database and, after applying clinical and bioinformatic exclusion criteria, worked with 581 prefrontal and frontal samples.

All datasets were analyzed using GEO2R from NCBI. We identified common genes using the Venny tool, and their metabolic relevance associated with AD and the vascular system was analyzed using MetaboAnalyst tools.

Results: Our bioinformatic analysis identified PRKCB, MAP2K2, ADCY1, GNA11, GNAQ, PRKACB, KCNMB4, CALD1, and GNAS as potentially involved in AD pathogenesis. These genes are associated with signal transductions, cell death signaling, and cytoskeleton, suggesting potential modulation of cellular physiology, including endoplasmic reticulum and mitochondrial activity.

Conclusion: This study generates hypotheses regarding the roles of novel genes over critical pathways relevant to AD and its relation with vascular dysfunction. These findings suggest potential new targets for further investigation into the pathogenesis of dementia and AD

Cite this article as:

Jara-Medina Kevins, Lillo Luis, Lagunas Constanza, Cabello-Guzmán Gerardo and Valenzuela-Melgarejo J. Francisco*, Identification of Vascular Genes Differentially Expressed in the Brain of Patients with Alzheimer's Disease, Current Vascular Pharmacology 2024; 22 () . https://dx.doi.org/10.2174/0115701611298073240612050741

DOI https://dx.doi.org/10.2174/0115701611298073240612050741	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212