The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis

Title:The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis

Volume: 24

Author(s): Jiayi Li, Yinxin Wu, Dingyin Zhang, Ziyan Zhang, Songqiang Li, Xi Cheng, Lihan Chen, Gang Zhou and Chengfu Yuan*

Affiliation:

• Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy，China Three Gorges University
• College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
• Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University

Abstract: Background: CPEB1 is an alternative polyadenylation binding protein that promotes or suppresses the expression of related mRNAs and proteins by binding to a highly conserved Cytoplasmic Polyadenylation Element (CPE) in the mRNAs 3’UTR. It is found to express abnormally in multiple tumors and affect tumorigenesis through many pathways. This review summarizes the functions and mechanisms of CPEB1 in a variety of cancers and suggests new directions for future related treatments.

Methods: A total of 95 articles were eligible for inclusion based on the year, quality of the research, and the strength of association with CPEB1. In this review, current research about how CPEB1 affects the initiation and progression of glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma are dissected, and the biomedical functions and mechanisms are summarized.

Results: CPEB1 mostly presents as a tumor suppressor for breast cancer, endometrial carcinoma, hepatocellular carcinoma, non-small cell lung cancer, prostate cancer, and melanoma. However, glioblastoma, gastric cancer, and colorectal cancer it exhibit two opposing properties of tumorigenesis, either promoting or inhibiting it.

Conclusion: CPEB1 is likely to serve as a target and dynamic detection index or prognostic indicator for its function of apoptosis, activity, proliferation, migration, invasion, stemness, drug resistance, and even ferroptosis in various cancers.

Cite this article as:

Li Jiayi, Wu Yinxin, Zhang Dingyin, Zhang Ziyan, Li Songqiang, Cheng Xi, Chen Lihan, Zhou Gang and Yuan Chengfu*, The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis, Mini-Reviews in Medicinal Chemistry 2024; 24 () . https://dx.doi.org/10.2174/0113895575293544240605112838