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Cardiovascular & Hematological Disorders-Drug Targets

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ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

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Mini-Review Article

Thrombosis in Myeloid Malignancies: From CHIP to AML

Author(s): Beatrice Borsellino, Carlos Bravo-Perez, Valeria Visconte and Luca Guarnera*

Volume 24, Issue 1, 2024

Published on: 11 June, 2024

Page: [2 - 12] Pages: 11

DOI: 10.2174/011871529X307253240530060107

Price: $65

Abstract

The development of myeloid malignancies is a multi-step process starting from pre-malignant stages. Large-scale studies on clonal hematopoiesis of indeterminate potential (CHIP) identified this condition as a risk factor for developing hematologic malignancies, in particular myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In parallel, CHIP was found to confer an enhanced thrombotic risk, in particular for cardiovascular diseases. In a similar fashion, in recent years, alongside their life-threatening features, increasing attention has been drawn toward thrombotic complications in myeloid malignancies. Thus, the purpose of this review is to gather a growing body of evidence on incidence, pathogenesis and clinical impact of thrombosis in myeloid malignancies at every step of malignant progression, from CHIP to AML.

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