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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Research Article

UPBEAT1-ROS-POD-PAL System under Different Xylogenesis Scenarios in Karelian Birch (Betula pendula Roth var. carelica (Mercl.) Hämet-Ahti)

Author(s): Kseniya Mihajlovna Nikerova*, Nataliya Alekseevna Galibina, Irina Nikolaevna Sofronova, Yuliya Leonidovna Moshchenskaya, Maksim Anatol'evich Korzhenevskij, Anna Vladimirovna Klimova and Tatiana Vladimirovna Tarelkina

Volume 31, Issue 5, 2024

Published on: 04 June, 2024

Page: [375 - 385] Pages: 11

DOI: 10.2174/0109298665291781240529044444

Price: $65

Abstract

Background: We studied UPBEAT1 (UPB1) which regulated superoxide radical / hydrogen peroxide ratio together with peroxidase (POD) activity and PAL genes expression under different ways of apical meristem development during the xylem structural elements’ formation in unique woody plants B. pendula var. pendula with straight-grained wood and B. pendula var. carelica with figured wood. The differentiation process predominanced in straight-grained wood (B. pendula var. pendula) or proliferation – in the figured wood. The investigation was conducted in the radial row (cambial zone - differentiating xylem - mature xylem) during the active cambial growth period.

Objective: The study aimed to study the xylogenesis processes occurring in the 16-year-old straight-grained silver birch (Betula pendula Roth) and Karelian birch (Betula pendula Roth var. carelica (Mercl.) Hämet-Ahti) with figured wood.

Methods: Hydrogen peroxide and superoxide radical contents and peroxidase activity were determined spectrophotometrically. Gene expression for PAL family genes and the UPBEAT1 gene was assessed using qRT-PCR.

Results: Principal component analysis has confirmed trees with straight-grained and figured wood to be different according to UPBEAT1-ROS-POD-PAL system functioning.

Conclusion: The higher superoxide radical/hydrogen peroxide ratio in figured Karelian birch, along with UPBEAT1 transcription factor and PAL genes upregulation, distinguished it from straight-grained silver birch. This metabolic picture confirmed the shift of Karelian birch xylogenesis towards proliferation processes, accompanied by ROS and phenolic compounds’ flow and POD activity.

Graphical Abstract

[1]
Tsukagoshi, H.; Busch, W.; Benfey, P.N. Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. Cell, 2010, 143(4), 606-616.
[http://dx.doi.org/10.1016/j.cell.2010.10.020] [PMID: 21074051]
[2]
Zeng, J.; Dong, Z.; Wu, H.; Tian, Z.; Zhao, Z. Redox regulation of plant stem cell fate. EMBO J., 2017, 36(19), 2844-2855.
[http://dx.doi.org/10.15252/embj.201695955] [PMID: 28838936]
[3]
a) Sorce, C.; Giovannelli, A.; Sebastiani, L.; Anfodillo, T. Hormonal signals involved in the regulation of cambial activity, xylogenesis and vessel patterning in trees. Xylem Cell Dev., 1981, 192-235.
[http://dx.doi.org/10.1007/s00299-013-1431-4];
b) Sorce, C.; Giovannelli, A. Hormonal signals involved in the regulation of cambial activity, xylogenesis and vessel patterning in trees. Plant Cell Rep., 2013, 32, 885-898.
[http://dx.doi.org/10.1007/s00299-013-1431-4]
[4]
Galibina, N.A.; Moshchenskaya, Y.L.; Tarelkina, T.V.; Chirva, O.V.; Nikerova, K.M.; Serkova, A.A.; Semenova, L.I.; Ivanova, D.S. Changes in the activity of the CLE41/PXY/WOX signaling pathway in the birch cambial zone under different xylogenesis patterns. Plants, 2022, 11(13), 1727.
[http://dx.doi.org/10.3390/plants11131727] [PMID: 35807679]
[5]
Albenne, C.; Canut, H.; Jamet, E. Plant cell wall proteomics: The leadership of Arabidopsis thaliana. Front. Plant Sci., 2013, 4, 111.
[http://dx.doi.org/10.3389/fpls.2013.00111] [PMID: 23641247]
[6]
Passardi, F.; Penel, C.; Dunand, C. Performing the paradoxical: How plant peroxidases modify the cell wall. Trends Plant Sci., 2004, 9(11), 534-540.
[http://dx.doi.org/10.1016/j.tplants.2004.09.002] [PMID: 15501178]
[7]
Pourcel, L.; Routaboul, J.M.; Kerhoas, L.; Caboche, M.; Lepiniec, L.; Debeaujon, I. TRANSPARENT TESTA10 encodes a laccase-like enzyme involved in oxidative polymerization of flavonoids in Arabidopsis seed coat. Plant Cell, 2005, 17(11), 2966-2980.
[http://dx.doi.org/10.1105/tpc.105.035154] [PMID: 16243908]
[8]
Bindschedler, L.V.; Dewdney, J.; Blee, K.A.; Stone, J.M.; Asai, T.; Plotnikov, J.; Denoux, C.; Hayes, T.; Gerrish, C.; Davies, D.R.; Ausubel, F.M.; Paul Bolwell, G. Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. Plant J., 2006, 47(6), 851-863.
[http://dx.doi.org/10.1111/j.1365-313X.2006.02837.x] [PMID: 16889645]
[9]
Quan, L.J.; Zhang, B.; Shi, W.W.; Li, H.Y. Hydrogen peroxide in plants: A versatile molecule of the reactive oxygen species network. J. Integr. Plant Biol., 2008, 50(1), 2-18.
[http://dx.doi.org/10.1111/j.1744-7909.2007.00599.x] [PMID: 18666947]
[10]
Ogawa, K.; Kanematsu, S.; Asada, K. Intra-and extra-cellular localization of “cytosolic” CuZn-superoxide dismutase in spinach leaf and hypocotyl. Plant Cell Physiol., 1996, 37(6), 790-799.
[http://dx.doi.org/10.1093/oxfordjournals.pcp.a029014]
[11]
Koutaniemi, S.; Warinowski, T.; Kärkönen, A.; Alatalo, E.; Fossdal, C.G.; Saranpää, P.; Laakso, T.; Fagerstedt, K.V.; Simola, L.K.; Paulin, L.; Rudd, S.; Teeri, T.H. Expression profiling of the lignin biosynthetic pathway in Norway spruce using EST sequencing and real-time RT-PCR. Plant Mol. Biol., 2007, 65(3), 311-328.
[http://dx.doi.org/10.1007/s11103-007-9220-5] [PMID: 17764001]
[12]
Weydert, C.J.; Cullen, J.J. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nat. Protoc., 2010, 5(1), 51-66.
[http://dx.doi.org/10.1038/nprot.2009.197] [PMID: 20057381]
[13]
Winterbourn, C.C. Biological production, detection, and fate of hydrogen peroxide. Antioxid. Redox Signal., 2018, 29(6), 541-551.
[http://dx.doi.org/10.1089/ars.2017.7425] [PMID: 29113458]
[14]
de Marco, A.; Roubelakis-Angelakis, K.A. The complexity of enzymic control of hydrogen peroxide concentration may affect the regeneration potential of plant protoplasts. Plant Physiol., 1996, 110(1), 137-145.
[http://dx.doi.org/10.1104/pp.110.1.137] [PMID: 12226176]
[15]
Zagoskina, N.V.; Zubova, M.Y.; Nechaeva, T.L.; Kazantseva, V.V.; Goncharuk, E.A.; Katanskaya, V.M. Polyphenols in plants: Structure, biosynthesis, abiotic stress regulation, and practical applications. Int. J. Mol. Sci., 2023, 24(18), 13874.
[http://dx.doi.org/10.3390/ijms241813874] [PMID: 37762177]
[16]
Loix, C.; Huybrechts, M.; Vangronsveld, J.; Gielen, M.; Keunen, E.; Cuypers, A. Reciprocal interactions between cadmium-induced cell wall responses and oxidative stress in plants. Front. Plant Sci., 2017, 8, 1867.
[http://dx.doi.org/10.3389/fpls.2017.01867] [PMID: 29163592]
[17]
Nikerova, K.M.; Galibina, N.A.; Moshchenskaya, Y.L.; Tarelkina, T.V.; Borodina, M.N.; Sofronova, I.N.; Semenova, L.I.; Ivanova, D.S.; Novitskaya, L.L. Upregulation of antioxidant enzymes is a biochemical indicator of abnormal xylogenesis in Karelian birch. Trees, 2022, 36(2), 517-529.
[http://dx.doi.org/10.1007/s00468-021-02225-5]
[18]
Nikerova, K.M.; Galibina, N.A.; Sofronova, I.N.; Borodina, M.N.; Moshchenskaya, Y.L.; Tarelkina, T.V.; Klimova, A.V.; Novitskaya, L.L. An indicating role of antioxidant system enzymes at the stage of active structural anomalies formation in karelian birch (Betula pendula Roth var. carelica (Mercl.) Hämet-Ahti). Protein Pept. Lett., 2023, 30(4), 325-334.
[http://dx.doi.org/10.2174/0929866530666230228113430] [PMID: 36852788]
[19]
Galibina, N.A.; Moshchenskaya, Y.L.; Tarelkina, T.V.; Nikerova, K.M.; Korzhenevskii, M.A.; Serkova, A.A.; Afoshin, N.V.; Semenova, L.I.; Ivanova, D.S.; Guljaeva, E.N.; Chirva, O.V. Identification and expression profile of CLE41/44-PXY-WOX genes in adult trees Pinus sylvestris L. Trunk tissues during cambial activity. Plants, 2023, 12(4), 835.
[http://dx.doi.org/10.3390/plants12040835] [PMID: 36840180]
[20]
Ershova, M.A.; Nikerova, K.M.; Galibina, N.A.; Sofronova, I.N.; Borodina, M.N. Some minor characteristics of spectrophotometric determination of antioxidant system and phenolic metabolism enzyme activity in wood plant tissues of Pinus sylvestris L. Protein Pept. Lett., 2022, 29(8), 711-720.
[http://dx.doi.org/10.2174/0929866529666220414104747] [PMID: 35430966]
[21]
Yang, J.; Cao, Y.; Zhang, N. Spectrophotometric method for superoxide anion radical detection in a visible light (400–780 nm) system. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2020, 239, 118556.
[http://dx.doi.org/10.1016/j.saa.2020.118556] [PMID: 32502811]
[22]
Brumbarova, T.; Le, C.; Bauer, P. Hydrogen peroxide measurement in arabidopsis root tissue using amplex red. Bio Protoc., 2016, 6(21), e1999.
[http://dx.doi.org/10.21769/BioProtoc.1999]
[23]
Moshchenskaya, Y.L.; Galibina, N.A.; Nikerova, K.M.; Tarelkina, T.V.; Korzhenevsky, M.A.; Sofronova, I.N.; Ershova, M.A.; Semenova, L.I. Plant-programmed cell death-associated genes participation in Pinus sylvestris L. Trunk tissue formation. Plants, 2022, 11(24), 3438.
[http://dx.doi.org/10.3390/plants11243438] [PMID: 36559551]
[24]
Moshchenskaya, Y.L.; Galibina, N.A.; Tarelkina, T.V.; Nikerova, K.M.; Korzhenevsky, M.A.; Semenova, L.I. Cambial age influences PCD gene expression during xylem development and heartwood formation. Plants, 2023, 12(23), 4072.
[http://dx.doi.org/10.3390/plants12234072] [PMID: 38068707]
[25]
Wells, D.M.; Wilson, M.H.; Bennett, M.J. Feeling UPBEAT about growth: Linking ROS gradients and cell proliferation. Dev. Cell, 2010, 19(5), 644-646.
[http://dx.doi.org/10.1016/j.devcel.2010.10.017] [PMID: 21074713]
[26]
Moschenskaya, Y.L.; Galibina, N.A.; Tarelkina, T.V.; Nikerova, K.M.; Chirva, O.V.; Novitskaya, L.L. Choice reference genes for the normalization of quantitative PCR data in real time in two forms of silver birch. Russ. J. Plant Physiol., 2021, 68(3), 430-439.
[http://dx.doi.org/10.1134/S1021443721020114]
[27]
Salojärvi, J.; Smolander, O.P.; Nieminen, K.; Rajaraman, S.; Safronov, O.; Safdari, P.; Lamminmäki, A.; Immanen, J.; Lan, T.; Tanskanen, J.; Rastas, P.; Amiryousefi, A.; Jayaprakash, B.; Kammonen, J.I.; Hagqvist, R.; Eswaran, G.; Ahonen, V.H.; Serra, J.A.; Asiegbu, F.O.; de Dios Barajas-Lopez, J.; Blande, D.; Blokhina, O.; Blomster, T.; Broholm, S.; Brosché, M.; Cui, F.; Dardick, C.; Ehonen, S.E.; Elomaa, P.; Escamez, S.; Fagerstedt, K.V.; Fujii, H.; Gauthier, A.; Gollan, P.J.; Halimaa, P.; Heino, P.I.; Himanen, K.; Hollender, C.; Kangasjärvi, S.; Kauppinen, L.; Kelleher, C.T.; Kontunen-Soppela, S.; Koskinen, J.P.; Kovalchuk, A.; Kärenlampi, S.O.; Kärkönen, A.K.; Lim, K.J.; Leppälä, J.; Macpherson, L.; Mikola, J.; Mouhu, K.; Mähönen, A.P.; Niinemets, Ü.; Oksanen, E.; Overmyer, K.; Palva, E.T.; Pazouki, L.; Pennanen, V.; Puhakainen, T.; Poczai, P.; Possen, B.J.H.M.; Punkkinen, M.; Rahikainen, M.M.; Rousi, M.; Ruonala, R.; van der Schoot, C.; Shapiguzov, A.; Sierla, M.; Sipilä, T.P.; Sutela, S.; Teeri, T.H.; Tervahauta, A.I.; Vaattovaara, A.; Vahala, J.; Vetchinnikova, L.; Welling, A.; Wrzaczek, M.; Xu, E.; Paulin, L.G.; Schulman, A.H.; Lascoux, M.; Albert, V.A.; Auvinen, P.; Helariutta, Y.; Kangasjärvi, J. Genome sequencing and population genomic analyses provide insights into the adaptive landscape of silver birch. Nat. Genet., 2017, 49(6), 904-912.
[http://dx.doi.org/10.1038/ng.3862] [PMID: 28481341]
[28]
Marchler-Bauer, A.; Bryant, S.H. CD-Search: protein domain annotations on the fly. Nucleic Acids Res., 2004, 32(Web Server), W327-W331.
[http://dx.doi.org/10.1093/nar/gkh454] [PMID: 15215404]
[29]
Tamura, K.; Stecher, G.; Kumar, S. MEGA11: Molecular evolutionary genetics analysis version 11. Mol. Biol. Evol., 2021, 38(7), 3022-3027.
[http://dx.doi.org/10.1093/molbev/msab120] [PMID: 33892491]
[30]
Saitou, N.; Nei, M. The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol. Biol. Evol., 1987, 4(4), 406-425.
[http://dx.doi.org/10.1093/oxfordjournals.molbev.a040454] [PMID: 3447015]
[31]
Marzec-Schmidt, K.; Wojciechowska, N.; Nemeczek, K.; Ludwików, A.; Mucha, J.; Bagniewska-Zadworna, A. Allies or enemies: The role of reactive oxygen species in developmental processes of black cottonwood (Populus trichocarpa). Antioxidants, 2020, 9(3), 199.
[http://dx.doi.org/10.3390/antiox9030199] [PMID: 32120843]
[32]
Dang, T.V.T.; Lee, S.; Cho, H.; Choi, K.; Hwang, I. The LBD11-ROS feedback regulatory loop modulates vascular cambium proliferation and secondary growth in Arabidopsis. Mol. Plant, 2023, 16(7), 1131-1145.
[http://dx.doi.org/10.1016/j.molp.2023.05.010] [PMID: 37264569]
[33]
Olson, P.D.; Varner, J.E. Hydrogen peroxide and lignification. Plant J, 1993, 4(5), 887-892.
[http://dx.doi.org/10.1046/j.1365-313X.1993.04050887.x]
[34]
Novitskaya, L.; Nikolaeva, N.; Galibina, N.; Tarelkina, T.; Semenova, L. The greatest density of parenchyma inclusions in Karelian birch wood occurs at confluences of phloem flows. Silva Fenn., 2016, 50(3), 1461-1478.
[http://dx.doi.org/10.14214/sf.1461]
[35]
Novitskaya, L.L.; Tarelkina, T.V.; Galibina, N.A.; Moshchenskaya, Y.L.; Nikolaeva, N.N.; Nikerova, K.M.; Podgornaya, M.N.; Sofronova, I.N.; Semenova, L.I. The formation of structural abnormalities in Karelian birch wood is associated with auxin inactivation and disrupted basipetal auxin transport. J. Plant Growth Regul., 2020, 39(1), 378-394.
[http://dx.doi.org/10.1007/s00344-019-09989-8]
[36]
Tarelkina, T.V.; Novitskaya, L.L.; Galibina, N.A.; Moshchenskaya, Y.L.; Nikerova, K.M.; Nikolaeva, N.N.; Sofronova, I.N.; Ivanova, D.S.; Semenova, L.I. Expression analysis of key auxin biosynthesis, transport, and metabolism genes of Betula pendula with special emphasis on figured wood formation in karelian birch. Plants, 2020, 9(11), 1406.
[http://dx.doi.org/10.3390/plants9111406] [PMID: 33105649]
[37]
Galibina, N.A.; Tarelkina, T.V.; Chirva, O.V.; Moshchenskaya, Y.L.; Nikerova, K.M.; Ivanova, D.S.; Semenova, L.I.; Serkova, A.A.; Novitskaya, L.L. Molecular genetic characteristics of different scenarios of xylogenesis on the example of two forms of silver birch differing in the ratio of structural elements in the xylem. Plants, 2021, 10(8), 1593.
[http://dx.doi.org/10.3390/plants10081593] [PMID: 34451638]
[38]
Serkova, A.; Tarelkina, T.; Galibina, N.; Nikerova, K.; Moshchenskaya, Y.; Sofronova, I.; Nikolaeva, N.; Ivanova, D.; Semenova, L.; Novitskaya, L. Changes in the differentiation program of birch cambial derivatives following trunk girdling. Forests, 2022, 13(8), 1171.
[http://dx.doi.org/10.3390/f13081171]
[39]
Nikerova, K.M.; Galibina, N.A.; Sofronova, I.N.; Moshchenskaya, Y.L.; Korzhenevskii, M.A.; Klimova, A.V.; Tarelkina, T.V.; Serkova, A.V. The role of O2-/H2O2 in the regulation of cambium stem cell differentiation under different xylogenesis scenarios. X Congress of society physiologists of plants of Russia “Plant Biology in the Era of Global Climate Change, 2023.
[http://dx.doi.org/10.31163/978-5-6047532-1-7]
[40]
Chen, Q.; Yang, G. Signal function studies of ROS, especially RBOH-dependent ROS, in plant growth, development and environmental stress. J. Plant Growth Regul., 2020, 39(1), 157-171.
[http://dx.doi.org/10.1007/s00344-019-09971-4]
[41]
Wang, P.; Liu, W.C.; Han, C.; Wang, S.; Bai, M.Y.; Song, C.P. Reactive oxygen species: Multidimensional regulators of plant adaptation to abiotic stress and development. J. Integr. Plant Biol., 2024, 66(3), 330-367.
[http://dx.doi.org/10.1111/jipb.13601] [PMID: 38116735]
[42]
Schmidt, R.; Schippers, J.H.M. ROS-mediated redox signaling during cell differentiation in plants. Biochim. Biophys. Acta, Gen. Subj., 2015, 1850(8), 1497-1508.
[http://dx.doi.org/10.1016/j.bbagen.2014.12.020] [PMID: 25542301]
[43]
MacDonald, M.J.; D’Cunha, G.B. A modern view of phenylalanine ammonia lyase. Biochem. Cell Biol., 2007, 85(3), 273-282.
[http://dx.doi.org/10.1139/O07-018] [PMID: 17612622]
[44]
Tsai, C.; Harding, S. A.; Tschaplinski, T. J.; Lindroth, R. L.; Yuan, Y. Genome-wide analysis of the structural genes regulating defense phenylpropanoid metabolism in Populus. New Phytol., 2006, 172(1), 47-62.
[http://dx.doi.org/10.1111/j.1469-8137.2006.01798.x]
[45]
Kao, Y.Y.; Harding, S.A.; Tsai, C.J. Differential expression of two distinct phenylalanine ammonia-lyase genes in condensed tannin-accumulating and lignifying cells of quaking aspen. Plant Physiol., 2002, 130(2), 796-807.
[http://dx.doi.org/10.1104/pp.006262] [PMID: 12376645]
[46]
Shi, R.; Shuford, C.M.; Wang, J.P.; Sun, Y.H.; Yang, Z.; Chen, H.C.; Tunlaya-Anukit, S.; Li, Q.; Liu, J.; Muddiman, D.C.; Sederoff, R.R.; Chiang, V.L. Regulation of phenylalanine ammonia-lyase (PAL) gene family in wood forming tissue of Populus trichocarpa. Planta, 2013, 238(3), 487-497.
[http://dx.doi.org/10.1007/s00425-013-1905-1] [PMID: 23765265]
[47]
Gaspar, T.; Kevers, C.; Hausman, J.F.; Faivre-Rampant, O.; Boyer, N.; Dommes, J. Integrating phytohormone metabolism and action with primary biochemical pathways. I. Interrelationships between auxins, cytokinins, ethylene and polyamines in growth and development processes. In: Integrated plant systems; University of Geneva: Switzerland, 2000; pp. 163-191.

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    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 59769557 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 59769557) limit 1
      11.85msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 59769557
      • 1: 59769557
      • 2: 59769557
      • 3: 59769557
      • 4: 59769557
      • 5: 59769557
      • 6: 59769557
      • 7: 59769557
      • 8: 59769557
      • 9: 59769557
      • 10: 59769557
      • 11: 59769557
      • 12: 59769557
      • 13: 59769557
      • 14: 59769557
      • 15: 59769557
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=140795
      760μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 51 limit 1
      810μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 51
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=51) and sj.journal_id!=51 group by `j`.`nid`) as `aggregate_table`
      860μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=51) and sj.journal_id!=51 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      740μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=51) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      5.02msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=51) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      3.42msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '140795'
      190μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 140795
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '140795'
      5.17msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 140795
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '140795' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.44msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 140795
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      240μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      470μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 51 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      28.99msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 51 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      21.22msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 51 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      12.35msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 140795 limit 1
      230μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 140795
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 140795 and content_type = 'article' order by status desc limit 1
      280μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 230655 limit 1
      240μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 230655
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      270μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'PPL' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      280μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: PPL
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '140795' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      420μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '13500' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3496' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      320μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3496) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3496) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3496)
      13.61msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13500) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13500) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13500)
      600μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140795) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140795) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59769557 and j.to_ip >=59769557 )) and ((j.from_date <= 1740496843 and j.to_date >= 1740496843 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140795)
      580μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '375' and is_uploaded = 1 and issue_id = 13500 order by cast(first_page as SIGNED) desc limit 1
      510μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 375
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '385' and is_uploaded = 1 and issue_id = 13500 order by cast(first_page as SIGNED) asc limit 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 385
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      260μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      230μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 140795 limit 1
      2.51msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 140795
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 51 and `b`.`banner_from_date` <= 1740496843 and `b`.`banner_to_date` >= 1740496843 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.18msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 51
      • 3: 1740496843
      • 4: 1740496843
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 51 and `b`.`banner_from_date` <= 1740496843 and `b`.`banner_to_date` >= 1740496843 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.16msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 51
      • 3: 1740496843
      • 4: 1740496843
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='7ce3c654c618f09bed2f7ccfb513a1f1'
      240μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        yGZKMlQZiXiS1v6ENcmUkBR3k6Ax6y8AQnY1uW6M
        uc_cart_id
        7ce3c654c618f09bed2f7ccfb513a1f1
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/140795" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/140795
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Imh6RUhmQW9SQTQvZmFPOUdBV255T0E9PSIsInZhbHVlIjoiejYxUGFFTDVDcWVLWFdlTGlsejJPTFdqNXRnTlYxaDdwekdtYTJrVlUzVT0iLCJtYWMiOiI1NmY5YjdkMTkwYTdiMzllMmUyMWYyMzdjYzU3ZGYzNDI4ZGYwNDQ1YzYzMjhlZjEwOTA0ZDA4ZTM4MDU4ZDJhIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Imh6RUhmQW9SQTQvZmFPOUdBV255T0E9PSIsInZhbHVlIjoiejYxUGFFTDVDcWVLWFdlTGlsejJPTFdqNXRnTlYxaDdwekdtYTJrVlUzVT0iLCJtYWMiOiI1NmY5YjdkMTkwYTdi" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
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