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Current Applied Polymer Science

Editor-in-Chief

ISSN (Print): 2452-2716
ISSN (Online): 2452-2724

Research Article

A Quality By Design (QbD) Prospect in Fabrication of PLGA-based Antipsychotic Long-acting Microspheres: An Alternative to Combination Therapy

Author(s): Akanksha Singh, Rajkiran Narkhede and Rajani Athawale*

Volume 7, Issue 1, 2024

Published on: 30 May, 2024

Page: [18 - 32] Pages: 15

DOI: 10.2174/0124522716306759240522112102

Price: $65

Abstract

Background: Discontinuation and poor compliance with long-term oral medicine are major therapeutic issues in psychosis treatment. Poorer long-term outcomes may result from non-compliance as well as a higher chance of relapse. In order to sustain therapeutic drug plasma levels, co-administration of oral antipsychotics is necessary for commercially available longacting injections of second-generation antipsychotics, as they have a lag period of approximately three weeks during the drug release process.

Methods: Poly(lactic-co-glycolic acid) (PLGA) encapsulated microspheres loaded with risperidone were fabricated in the current research for intramuscular administration. The single emulsion solvent evaporation technique was applied for the fabrication of microspheres. Risperidone microspheres were prepared using PLGA grade 75:25. Particle size, drug content and entrapment efficiency with a central composite design were the main optimization parameters for the formulation. The microspheres were characterized by different techniques, namely Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), X-ray diffractometry (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The drug content, entrapment efficiency, morphology, particle size, and in vitro release profiles, along with release kinetics of the risperidone microspheres, were studied.

Results and Discussion: The microspheres produced by the single emulsion solvent evaporation approach show smooth and spherical morphology, with particle size ranging from 3 μm to 6 μm, drug content of 99.7%, and entrapment efficiency of 98.2% with little burst release of 3% to 10%, providing drug release for 45 days and exhibiting zero order release kinetics and Korsmeyer- Peppas model for non-fickian drug release from the polymeric matrix. By applying the Quality by Design (QbD) approach and formulation parameters, microspheres with appropriate particle size, morphology, enhanced drug content, entrapment efficiency and desirable drug release profile for depot formulation can be obtained successfully.

Conclusion: The optimized microspheres, in comparison to the marketed Risperdal Consta™, show enhanced potential for a better depot formulation, which can further improve patient compliance.

Graphical Abstract

[1]
Rubio MD, Drummond JB, Meador-Woodruff JH. Glutamate receptor abnormalities in schizophrenia: implications for innovative treatments. Biomol Ther 2012; 20(1): 1-18.
[http://dx.doi.org/10.4062/biomolther.2012.20.1.001] [PMID: 24116269]
[2]
Rössler W, Joachim Salize H, van Os J, Riecher-Rössler A. Size of burden of schizophrenia and psychotic disorders. Eur Neuropsychopharmacol 2005; 15(4): 399-409.
[http://dx.doi.org/10.1016/j.euroneuro.2005.04.009] [PMID: 15925493]
[3]
Practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry 1997; 154(4): 1-63.
[http://dx.doi.org/10.1176/ajp.154.4.1]
[4]
Su ZX, Shi YN, Teng LS, et al. Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres for sustained release of risperidone: Zero-order release formulation. Pharm Dev Technol 2011; 16(4): 377-84.
[http://dx.doi.org/10.3109/10837451003739297] [PMID: 20370594]
[5]
Baweja R, Sedky K, Lippmann S. Long-acting antipsychotic medications. Curr Drug Targets 2012; 13(4): 555-60.
[http://dx.doi.org/10.2174/138945012799499785] [PMID: 22250654]
[6]
Kane JM, Aguglia E, Altamura AC, et al. Guidelines for depot antipsychotic treatment in schizophrenia. Eur Neuropsychopharmacol 1998; 8(1): 55-66.
[http://dx.doi.org/10.1016/S0924-977X(97)00045-X] [PMID: 9452941]
[7]
Barnes TRE, Curson DA. Long-term depot antipsychotics. A risk-benefit assessment. Drug Saf 1994; 10(6): 464-79.
[http://dx.doi.org/10.2165/00002018-199410060-00005] [PMID: 7917075]
[8]
Nayak RK, Doose DR, Nair NPV. The bioavailability and pharmacokinetics of oral and depot intramuscular haloperidol in schizophrenic patients. J Clin Pharmacol 1987; 27(2): 144-50.
[http://dx.doi.org/10.1002/j.1552-4604.1987.tb02175.x] [PMID: 3680566]
[9]
Schwendeman SP, Shah RB, Bailey BA, Schwendeman AS. Injectable controlled release depots for large molecules. J Control Release 2014; 190: 240-53.
[http://dx.doi.org/10.1016/j.jconrel.2014.05.057] [PMID: 24929039]
[10]
Wan F, Yang M. Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying. Int J Pharm 2016; 498(1-2): 82-95.
[http://dx.doi.org/10.1016/j.ijpharm.2015.12.025] [PMID: 26688034]
[11]
Fleischhacker WW. Second-generation antipsychotic long-acting injections: Systematic review. Br J Psychiatry 2009; 195(S52): s29-36.
[http://dx.doi.org/10.1192/bjp.195.52.s29] [PMID: 19880914]
[12]
Chaurasia S, Mounika K, Bakshi V, Prasad V. 3-month parenteral PLGA microsphere formulations of risperidone: Fabrication, characterization and neuropharmacological assessments. Mater Sci Eng C 2017; 75: 1496-505.
[http://dx.doi.org/10.1016/j.msec.2017.03.065] [PMID: 28415443]
[13]
Davis JM, Metalon L, Watanabe MD, Blake L. Depot antipsychotic drugs: Place in therapy. Drugs 1994; 47(5): 741-73.
[http://dx.doi.org/10.2165/00003495-199447050-00004] [PMID: 7520856]
[14]
Kane JM. Pharmacologic treatment of schizophrenia. Biol Psychiatry 1999; 46(10): 1396-408.
[http://dx.doi.org/10.1016/S0006-3223(99)00059-1] [PMID: 10578454]
[15]
Johnson D. Long-term drug treatment of psychosis: Observations on some current issues. Int Rev Psychiatry 1990; 2(3-4): 341-53.
[http://dx.doi.org/10.3109/09540269009026605]
[16]
Wyatt RJ. Neuroleptics and the natural course of schizophrenia. Schizophr Bull 1991; 17(2): 325-51.
[http://dx.doi.org/10.1093/schbul/17.2.325] [PMID: 1679255]
[17]
Kane JM, Eerdekens M, Lindenmayer JP, Keith SJ, Lesem M, Karcher K. Long-acting injectable risperidone: Efficacy and safety of the first long-acting atypical antipsychotic. Am J Psychiatry 2003; 160(6): 1125-32.
[http://dx.doi.org/10.1176/appi.ajp.160.6.1125] [PMID: 12777271]
[18]
Adams CE, Fenton MKP, Quraishi S, David AS. Systematic meta-review of depot antipsychotic drugs for people with schizophrenia. Br J Psychiatry 2001; 179(4): 290-9.
[http://dx.doi.org/10.1192/bjp.179.4.290] [PMID: 11581108]
[19]
Davis JM, Janicak PG, Singla A, Sharma RP. Antipsychotic Drugs and Their Side-Effects Chap Maintenance medication. London: Academic Press 1993; pp. 183-203.
[http://dx.doi.org/10.1016/B978-0-12-079035-7.50019-1]
[20]
Ramstack M, Grandolfi GP, Mannaert E, D’Hoore P, Lasser RA. Long-acting risperidone: Prolonged-release injectable delivery of risperidone using medisorbò microsphere technology. Schizophr Res 2003; 60(1): 314.
[http://dx.doi.org/10.1016/S0920-9964(03)80260-8]
[21]
Davis SS, Hardy JG, Newman SP, Wilding IR. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nucl Med 1992; 19(11): 971-86.
[http://dx.doi.org/10.1007/BF00175865] [PMID: 1425786]
[22]
Cheng YH, Illum L, Davis SS. A poly(d,l-lactide-co-glycolide) microsphere depot system for delivery of haloperidol. J Control Release 1998; 55(2-3): 203-12.
[http://dx.doi.org/10.1016/S0168-3659(98)00056-X] [PMID: 9795060]
[23]
Knox ED, Stimmel GL. Clinical review of a long-acting, injectable formulation of risperidone. Clin Ther 2004; 26(12): 1994-2002.
[http://dx.doi.org/10.1016/j.clinthera.2004.12.009] [PMID: 15823763]
[24]
Love RC, Conley RJ. Long-acting risperidone injection. Am J Health Syst Pharm 2004; 61(17): 1792-800.
[http://dx.doi.org/10.1093/ajhp/61.17.1792] [PMID: 15462250]
[25]
Leal A, Rosillon D, Mehnert A, Jarema M, Remington G. Healthcare resource utilization during 1‐year treatment with long‐acting, injectable risperidone. Pharmacoepidemiol Drug Saf 2004; 13(11): 811-6.
[http://dx.doi.org/10.1002/pds.978] [PMID: 15386706]
[26]
D’Souza S, Faraj JA, Giovagnoli S, DeLuca PP. Development of risperidone PLGA microspheres. J Drug Deliv 2014; 620464.
[http://dx.doi.org/10.1155/2014/620464]
[27]
Orkoula MG, Kontoyannis CG. Non-destructive quantitative analysis of risperidone in film-coated tablets. J Pharm Biomed Anal 2008; 47(3): 631-5.
[http://dx.doi.org/10.1016/j.jpba.2008.01.049] [PMID: 18359600]
[28]
Giovagnoli S, Blasi P, Ricci M, Rossi C. Biodegradable microspheres as carriers for native superoxide dismutase and catalase delivery. AAPS PharmSciTech 2004; 5(4): 1-9.
[http://dx.doi.org/10.1208/pt050451] [PMID: 15760048]
[29]
Gref R, Quellec P, Sanchez A, Calvo P, Dellacherie E, Alonso MJ. Development and characterization of CyA-loaded poly(lactic acid)–poly(ethylene glycol)PEG micro- and nanoparticles. Comparison with conventional PLA particulate carriers. Eur J Pharm Biopharm 2001; 51(2): 111-8.
[http://dx.doi.org/10.1016/S0939-6411(00)00143-0] [PMID: 11226817]
[30]
Khang G, Rhee JM, Jeong JK, et al. Local drug delivery system using biodegradable polymers. Macromol Res 2003; 11(4): 207-23.
[http://dx.doi.org/10.1007/BF03218355]
[31]
Hausberger AG, DeLuca PP. Characterization of biodegradable poly(d,l-lactide-co-glycolide) polymers and microspheres. J Pharm Biomed Anal 1995; 13(6): 747-60.
[http://dx.doi.org/10.1016/0731-7085(95)01276-Q] [PMID: 7669829]
[32]
Edlund U, Albertsson AC. Degradable polymer microspheres for controlled drug delivery. Degradable aliphatic polyesters 2002; 67-112.
[http://dx.doi.org/10.1007/3-540-45734-8_3]
[33]
Okada H. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv Drug Deliv Rev 1997; 28(1): 43-70.
[http://dx.doi.org/10.1016/S0169-409X(97)00050-1] [PMID: 10837564]
[34]
D’Souza SS, Selmin F, Murty SB, Qiu W, Thanoo BC, DeLuca PP. Assessment of fertility in male rats after extended chemical castration with a GnRH antagonist. AAPS PharmSci 2004; 6(1): 94-9.
[http://dx.doi.org/10.1208/ps060110] [PMID: 15198511]
[35]
Okada H, Doken Y, Ogawa Y, Toguchi H. Preparation of three-month depot injectable microspheres of leuprorelin acetate using biodegradable polymers. Pharm Res 1994; 11(8): 1143-7.
[http://dx.doi.org/10.1023/A:1018936815654] [PMID: 7971715]
[36]
Woo BH, Kostanski JW, Gebrekidan S, Dani BA, Thanoo BC, DeLuca PP. Preparation, characterization and in vivo evaluation of 120-day poly(d,l-lactide) leuprolide microspheres. J Control Release 2001; 75(3): 307-15.
[http://dx.doi.org/10.1016/S0168-3659(01)00403-5] [PMID: 11489318]
[37]
Woo BH, Na KH, Dani BA, Jiang G, Thanoo BC, DeLuca PP. In vitro characterization and in vivo testosterone suppression of 6-month release poly(D,L-lactide) leuprolide microspheres. Pharm Res 2002; 19(4): 546-50.
[http://dx.doi.org/10.1023/A:1015168301339] [PMID: 12033393]
[38]
Chue P, Eerdekens M, Augustyns I, et al. Comparative efficacy and safety of long-acting risperidone and risperidone oral tablets. Eur Neuropsychopharmacol 2005; 15(1): 111-7.
[http://dx.doi.org/10.1016/j.euroneuro.2004.07.003] [PMID: 15572280]
[39]
Burgess D, Hickey A. Microspheres. Drugs and the Pharmaceutical Sciences 2005; 149: 305-53.
[http://dx.doi.org/10.1201/9780849350610.ch9]
[40]
Hickey T, Kreutzer D, Burgess DJ, Moussy F. Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices. Biomaterials 2002; 23(7): 1649-56.
[http://dx.doi.org/10.1016/S0142-9612(01)00291-5] [PMID: 11922468]
[41]
Park TG. Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials 1995; 16(15): 1123-30.
[http://dx.doi.org/10.1016/0142-9612(95)93575-X] [PMID: 8562787]
[42]
Beg S, Rahman M, Panda SS. Pharmaceutical QbD: Omnipresence in the product development lifecycle. Eur Pharm Rev 2017; 22(1): 58-64.
[43]
Singh B, Beg S. Quality by design in product development life cycle. Chronicle Pharmabiz 2013; 22: 72-9.
[44]
Bhoop BS, Raza K, Beg S. Developing “optimized” drug products employing “designed” experiments. Chemical Industry Digest 2013; 23: 70-6.
[45]
Rose F, Wern JE, Ingvarsson PT, et al. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. J Control Release 2015; 210: 48-57.
[http://dx.doi.org/10.1016/j.jconrel.2015.05.004] [PMID: 25957906]
[46]
Chu D, Tian J, Liu W, Li Z, Li Y. Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: In vitro and in vivo studies and the application in the treatment of the impaired memory of mice. Chem Pharm Bull 2007; 55(4): 625-8.
[http://dx.doi.org/10.1248/cpb.55.625] [PMID: 17409558]
[47]
Su Z, Sun F, Shi Y, et al. Effects of formulation parameters on encapsulation efficiency and release behavior of risperidone poly(D,L-lactide-co-glycolide) microsphere. Chem Pharm Bull 2009; 57(11): 1251-6.
[http://dx.doi.org/10.1248/cpb.57.1251] [PMID: 19881277]
[48]
Al-Kassas R. Design and in vitro evaluation of gentamicin–Eudragit microspheres intended for intra-ocular administration. J Microencapsul 2004; 21(1): 71-81.
[http://dx.doi.org/10.1080/02652040310001619992] [PMID: 14718187]
[49]
Gao L, Zhang D, Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 2008; 10(5): 845-62.
[http://dx.doi.org/10.1007/s11051-008-9357-4]
[50]
Liu WH, Song JL, Liu K, Chu DF, Li YX. Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer’s disease. J Control Release 2005; 107(3): 417-27.
[http://dx.doi.org/10.1016/j.jconrel.2005.03.025] [PMID: 16154224]
[51]
Berkland C, Kipper MJ, Narasimhan B, Kim KK, Pack DW. Microsphere size, precipitation kinetics and drug distribution control drug release from biodegradable polyanhydride microspheres. J Control Release 2004; 94(1): 129-41.
[http://dx.doi.org/10.1016/j.jconrel.2003.09.011] [PMID: 14684277]
[52]
Yildiz BC, Kayan A. Ti(IV)-silyliminophenolate catalysts for ϵ-caprolactone and L-Lactide polymerization. Sustain Chem Pharm 2021; 21100416.
[http://dx.doi.org/10.1016/j.scp.2021.100416]
[53]
Kayan GÖ, Kayan A. Polycaprolactone composites/blends and their applications especially in water treatment. ChemEngineering 2023; 7(6): 104.
[http://dx.doi.org/10.3390/chemengineering7060104]
[54]
Daniel JSP, Veronez IP, Rodrigues LL, Trevisan MG, Garcia JS. Risperidone – Solid-state characterization and pharmaceutical compatibility using thermal and non-thermal techniques. Thermochim Acta 2013; 568: 148-55.
[http://dx.doi.org/10.1016/j.tca.2013.06.032]
[55]
Karavelidis V, Giliopoulos D, Karavas E, Bikiaris D. Nanoencapsulation of a water soluble drug in biocompatible polyesters. Effect of polyesters melting point and glass transition temperature on drug release behavior. Eur J Pharm Sci 2010; 41(5): 636-43.
[http://dx.doi.org/10.1016/j.ejps.2010.09.004] [PMID: 20863892]
[56]
Karavelidis V, Bikiaris D, Avgoustakis K. New thermosensitive nanoparticles prepared by biocompatible pegylated aliphatic polyester block copolymers for local cancer treatment. J Pharm Pharmacol 2015; 67(2): 215-30.
[http://dx.doi.org/10.1111/jphp.12337] [PMID: 25616209]
[57]
Beslikas T, Gigis I, Goulios V, Christoforides J, Papageorgiou GZ, Bikiaris DN. Crystallization study and comparative in vitro-in vivo hydrolysis of PLA reinforcement ligament. Int J Mol Sci 2011; 12(10): 6597-618.
[http://dx.doi.org/10.3390/ijms12106597] [PMID: 22072906]
[58]
Papageorgiou GZ, Beslikas T, Gigis J, Christoforides J, Bikiaris DN. Crystallization and enzymatic hydrolysis of PLA grade for orthopedics. Adv Polym Technol 2010; 29(4): 280-99.
[http://dx.doi.org/10.1002/adv.20194]
[59]
Raman C, Berkland C, Kim KK, Pack DW. Modeling small-molecule release from PLG microspheres: Effects of polymer degradation and nonuniform drug distribution. J Control Release 2005; 103(1): 149-58.
[http://dx.doi.org/10.1016/j.jconrel.2004.11.012] [PMID: 15773062]
[60]
Ramstack J, Grandolfi G, Mannaert E, D’Hoore P, Lasser RA. Risperdal Consta TM: prolonged-release injectable delivery of risperidone using Medisorb VR microsphere technology. Abstr Am Assoc Pharm Sci 2002; 4: S1.
[61]
Siafaka PI, Barmpalexis P, Lazaridou M, et al. Controlled release formulations of risperidone antipsychotic drug in novel aliphatic polyester carriers: Data analysis and modelling. Eur J Pharm Biopharm 2015; 94: 473-84.
[http://dx.doi.org/10.1016/j.ejpb.2015.06.027] [PMID: 26159838]
[62]
Hoffman AS. The origins and evolution of “controlled” drug delivery systems. J Control Release 2008; 132(3): 153-63.
[http://dx.doi.org/10.1016/j.jconrel.2008.08.012] [PMID: 18817820]
[63]
Wu F, Jin T. Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances. AAPS PharmSciTech 2008; 9(4): 1218-29.
[http://dx.doi.org/10.1208/s12249-008-9148-3] [PMID: 19085110]
[64]
Mitragotri S, Burke PA, Langer R. Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies. Nat Rev Drug Discov 2014; 13(9): 655-72.
[http://dx.doi.org/10.1038/nrd4363] [PMID: 25103255]
[65]
Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. J Microencapsul 2005; 22(7): 705-14.
[http://dx.doi.org/10.1080/02652040500162196] [PMID: 16421082]
[66]
Huang Z, Chen X, Fu H, et al. Formation mechanism and in vitro evaluation of risperidone-containing PLGA microspheres fabricated by ultrafine particle processing system. J Pharm Sci 2017; 106(11): 3363-71.
[http://dx.doi.org/10.1016/j.xphs.2017.07.010] [PMID: 28736289]
[67]
Hu Z, Liu Y, Yuan W, Wu F, Su J, Jin T. Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf B Biointerfaces 2011; 86(1): 206-11.
[http://dx.doi.org/10.1016/j.colsurfb.2011.03.043] [PMID: 21524893]
[68]
Georgiadis MC, Kostoglou M. On the optimization of drug release from multi-laminated polymer matrix devices. J Control Release 2001; 77(3): 273-85.
[http://dx.doi.org/10.1016/S0168-3659(01)00510-7] [PMID: 11733095]
[69]
Iordanskii AL, Zaikov GE, Berlin AA. Diffusion kinetics of hydrolysis of biodegradable polymers. Weight loss and control of the release of low molecular weight substances. Polym Sci Ser D Glues Sealing Mater 2015; 8(3): 211-8.
[http://dx.doi.org/10.1134/S1995421215030053]
[70]
Nanaki S, Barmpalexis P, Iatrou A, Christodoulou E, Kostoglou M, Bikiaris D. Risperidone controlled release microspheres based on poly (lactic acid)-poly (propylene adipate) novel polymer blends appropriate for long acting injectable formulations. Pharmaceutics 2018; 10(3): 130.
[http://dx.doi.org/10.3390/pharmaceutics10030130] [PMID: 30104505]
[71]
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm 1983; 15(1): 25-35.
[http://dx.doi.org/10.1016/0378-5173(83)90064-9]
[72]
Crank J. The mathematics of diffusion. Oxford University Press 1979.
[73]
Barmpalexis P, Kachrimanis K, Malamataris S. Statistical moments in modelling of swelling, erosion and drug release of hydrophilic matrix-tablets. Int J Pharm 2018; 540(1-2): 1-10.
[http://dx.doi.org/10.1016/j.ijpharm.2018.01.052] [PMID: 29407874]

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      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316511805 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316511805) limit 1
      12.16msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316511805
      • 1: 316511805
      • 2: 316511805
      • 3: 316511805
      • 4: 316511805
      • 5: 316511805
      • 6: 316511805
      • 7: 316511805
      • 8: 316511805
      • 9: 316511805
      • 10: 316511805
      • 11: 316511805
      • 12: 316511805
      • 13: 316511805
      • 14: 316511805
      • 15: 316511805
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=140717
      610μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 166 limit 1
      360μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 166
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=166) and sj.journal_id!=166 group by `j`.`nid`) as `aggregate_table`
      470μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=166) and sj.journal_id!=166 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      390μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=166) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      540μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=166) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      480μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '140717'
      170μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 140717
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '140717'
      5.33msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 140717
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '140717' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.14msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 140717
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      220μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      410μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 166 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      28.05msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 166 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      1.3msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 166 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      1.14msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 140717 limit 1
      150μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 140717
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 140717 and content_type = 'article' order by status desc limit 1
      210μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 230527 limit 1
      170μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 230527
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      190μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CAPS' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      220μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CAPS
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '140717' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '13532' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      260μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3536' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      240μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3536) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3536) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3536)
      21.64msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13532) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13532) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13532)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140717) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140717) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316511805 and j.to_ip >=316511805 )) and ((j.from_date <= 1740346650 and j.to_date >= 1740346650 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 140717)
      580μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '18' and is_uploaded = 1 and issue_id = 13532 order by cast(first_page as SIGNED) desc limit 1
      480μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 18
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '32' and is_uploaded = 1 and issue_id = 13532 order by cast(first_page as SIGNED) asc limit 1
      430μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 32
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      180μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      210μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 140717 limit 1
      2.43msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 140717
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 166 and `b`.`banner_from_date` <= 1740346650 and `b`.`banner_to_date` >= 1740346650 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.13msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 166
      • 3: 1740346650
      • 4: 1740346650
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 166 and `b`.`banner_from_date` <= 1740346650 and `b`.`banner_to_date` >= 1740346650 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 166
      • 3: 1740346650
      • 4: 1740346650
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='ba073e5f74ef20044f7a42b0bc225dbf'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        WKTas0QgVOE40W9F1OadWsaNysks5PL05jHC40xQ
        uc_cart_id
        ba073e5f74ef20044f7a42b0bc225dbf
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/140717" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/140717
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:37:30 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ikh6a1VtdWs5WStWbWlodklhSE1QUlE9PSIsInZhbHVlIjoiS2tWeEx1TDVhbG9PQ0VhY04wLzYvOE9ZSUxVNStqSm90Y1JtL1VUMTlQOGI5RldIditTNjNZU2VobW53MGxNWHB3OXFCelhHMTkrcllybXJHZm5kL2h2TW82MjZ0NWprdGIxd3hoQ0cvSmk0RzI2Q3Fwb0hkTHpSaEFwSnVkSkwiLCJtYWMiOiIyZGU1ODgyYzcyMTAzODkxMmMzMmVjNDczNTlmYzM3YWQ1ZTdlZTIyZDI1NDBkMzRhODI1Nzk5OTA0MzQ4YjE4IiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:37:30 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ikh6a1VtdWs5WStWbWlodklhSE1QUlE9PSIsInZhbHVlIjoiS2tWeEx1TDVhbG9PQ0VhY04wLzYvOE9ZSUxVNStqSm90Y1JtL1VUMTlQOGI5RldIditTNjNZU2VobW53MGxNWHB3OXFCe" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjE3RU5DSnlLc0JZZUg4MFlhWjFBbnc9PSIsInZhbHVlIjoicDJTMlQrSE9GQkg5YU9IQjZ0L3B2QmJCWE11ck5oMndPaTQ1Z0J1bGp5TEVhQmJXVmFTbWNpKzVyU3Bvb0xtOTcyalR2QmIyeDdNYzI3VzZ5dFl4VjEvSXV0bGxVTVJUZThNK0ZTaVVyMnBMaDlRVmVGcCtSeXhPb2dWa21EZWwiLCJtYWMiOiJkYTZiNTRhODI2MDM5ZjVhMmM0YzA0ZjdhZjZjNzNiMzU3NDFkZDdjYzY2MzBiNzVlYTIxNWI0NmU3OTE3YzMwIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjE3RU5DSnlLc0JZZUg4MFlhWjFBbnc9PSIsInZhbHVlIjoicDJTMlQrSE9GQkg5YU9IQjZ0L3B2QmJCWE11ck5oMndPaTQ1Z0J1bGp5TEVhQmJXVmFTbWNpKzV" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ikh6a1VtdWs5WStWbWlodklhSE1QUlE9PSIsInZhbHVlIjoiS2tWeEx1TDVhbG9PQ0VhY04wLzYvOE9ZSUxVNStqSm90Y1JtL1VUMTlQOGI5RldIditTNjNZU2VobW53MGxNWHB3OXFCelhHMTkrcllybXJHZm5kL2h2TW82MjZ0NWprdGIxd3hoQ0cvSmk0RzI2Q3Fwb0hkTHpSaEFwSnVkSkwiLCJtYWMiOiIyZGU1ODgyYzcyMTAzODkxMmMzMmVjNDczNTlmYzM3YWQ1ZTdlZTIyZDI1NDBkMzRhODI1Nzk5OTA0MzQ4YjE4IiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:37:30 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ikh6a1VtdWs5WStWbWlodklhSE1QUlE9PSIsInZhbHVlIjoiS2tWeEx1TDVhbG9PQ0VhY04wLzYvOE9ZSUxVNStqSm90Y1JtL1VUMTlQOGI5RldIditTNjNZU2VobW53MGxNWHB3OXFCe" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjE3RU5DSnlLc0JZZUg4MFlhWjFBbnc9PSIsInZhbHVlIjoicDJTMlQrSE9GQkg5YU9IQjZ0L3B2QmJCWE11ck5oMndPaTQ1Z0J1bGp5TEVhQmJXVmFTbWNpKzVyU3Bvb0xtOTcyalR2QmIyeDdNYzI3VzZ5dFl4VjEvSXV0bGxVTVJUZThNK0ZTaVVyMnBMaDlRVmVGcCtSeXhPb2dWa21EZWwiLCJtYWMiOiJkYTZiNTRhODI2MDM5ZjVhMmM0YzA0ZjdhZjZjNzNiMzU3NDFkZDdjYzY2MzBiNzVlYTIxNWI0NmU3OTE3YzMwIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjE3RU5DSnlLc0JZZUg4MFlhWjFBbnc9PSIsInZhbHVlIjoicDJTMlQrSE9GQkg5YU9IQjZ0L3B2QmJCWE11ck5oMndPaTQ1Z0J1bGp5TEVhQmJXVmFTbWNpKzV" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "WKTas0QgVOE40W9F1OadWsaNysks5PL05jHC40xQ" "uc_cart_id" => "ba073e5f74ef20044f7a42b0bc225dbf" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/140717" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
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