Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs

Title:Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs

Volume: 24 Issue: 21

Author(s): Hongyan Yang, Ping Xu, Fei Pan, Jinhong Gao, Libo Yuan and Kui Lu*

Affiliation:

• College of Food Science and Engineering, Henan University of Technology, Zhengzhou, 450001, China
• School of Chemical Engineering and Food Science, Zhengzhou University of Technology, Zhengzhou, 450044, China

Abstract: Guanine-quadruplexes (G4s) are high-level structures formed by the folding of guaninerich nucleic acid sequences. G4s play important roles in various physiological processes, such as gene transcription, replication, recombination, and maintenance of chromosomal stability. Specific and sensitive monitoring of G4s lays the foundation for further understanding the structure, content, distribution, and function of G4s in organisms, which is important for the treatment and diagnosis of diseases. Moreover, visualization of G4s will provide new ideas for developing antitumor strategies targeting G4s. The design and development of G4-specific ligands are challenging due to the subtle differences in the structure of G4s. This review focuses on the progress of research on G4 fluorescent probes and their binding mechanisms to G4s. Finally, the challenges and future prospects for better detection and targeting of G4s in different organisms are discussed. This paper provides ideas for the development of novel G4 fluorescent probes.

Cite this article as:

Yang Hongyan, Xu Ping, Pan Fei, Gao Jinhong, Yuan Libo and Lu Kui*, Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs, Mini-Reviews in Medicinal Chemistry 2024; 24 (21) . https://dx.doi.org/10.2174/0113895575301818240510151309