Recent Advances in Trifluoromethylation of Olefins, Aldehydes, and Ketones

Title:Recent Advances in Trifluoromethylation of Olefins, Aldehydes, and Ketones

Volume: 28 Issue: 16

Author(s): Mengran Bai, Liyuan Zhang, Lu Liu, Chenyu Jia, Yuting Zheng, Huijian Shang, Hui Sun*Bin Cui*

Affiliation:

• Manganese Catalysis and Asymmetric Synthesis Laboratory, College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China

• Manganese Catalysis and Asymmetric Synthesis Laboratory, College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China

Abstract: Due to the robust electrophilic properties of the trifluoromethyl group (-CF₃), its incorporation into organic compounds can markedly alter their ester affinity, stability, bioavailability, and other properties. The trifluoromethylation reaction is currently experiencing rapid advancement, with an expanding array of substrates and the emergence of novel methodologies. Consequently, compounds containing the -CF₃ moiety find extensive utility across diverse fields. This article aims to comprehensively review the latest advancements in trifluoromethylation reaction of olefins, aldehydes, and ketones, encompassing nucleophilic trifluoromethylation, electrophilic trifluoromethylation, and radical trifluoromethylation. The discussion includes an exploration of the types and broadening scope of applicable substrates. Furthermore, this article addresses the associated challenges and delineates prospective directions for future developments in trifluoromethyl reaction.

Cite this article as:

Bai Mengran, Zhang Liyuan, Liu Lu, Jia Chenyu, Zheng Yuting, Shang Huijian, Sun Hui*, Cui Bin*, Recent Advances in Trifluoromethylation of Olefins, Aldehydes, and Ketones, Current Organic Chemistry 2024; 28 (16) . https://dx.doi.org/10.2174/0113852728305885240506155446