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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options

Author(s): Chrysi Pouliou and Christina Piperi*

Volume 31, Issue 38, 2024

Published on: 09 May, 2024

Page: [6187 - 6203] Pages: 17

DOI: 10.2174/0109298673297545240507091410

Price: $65

Abstract

Periodontitis is the most common inflammatory oral disease that affects around 15% of adults and contributes to severe periodontal tissue destruction with subsequent tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis, excessive reactive oxygen species production and oxidative stress play a predominant role in inducing both local and systemic damage. Current therapeutic approaches have expanded the conventional methods combined with herbal antioxidant compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering promising pre-clinical evidence in periodontitis management. Herein, we review the pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances in oxidative stress biomarkers and novel targeting options.

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