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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Mini-Review Article

One-pot Synthesis of Condensed Azepines

Author(s): Khushboo Bhardwaj, Shivangi Jaiswal, Annu Bhardwaj, Dharma Kishore, Jaya Dwivedi* and Swapnil Sharma

Volume 28, Issue 11, 2024

Published on: 03 May, 2024

Page: [815 - 829] Pages: 15

DOI: 10.2174/0113852728300551240408054904

Price: $65

Abstract

Azepine is a privileged nitrogen-containing ring that has been found to display a wide range of biological activities. Azepine is a valuable skeleton in designing novel compounds in medicinal chemistry due to its interesting chemical and biological properties. The study on the synthesis of this ring system engenders a fascinating area of research owing to its potential to form an active pharmacophore for De Novo exploration. In this study, conventional and domino results were compared to access the diverse set of azepines in high yield. The domino approach has revolutionized the way through which the previously impossible yet significant transformations could be conceptualized, allowing the construction of difficult materials in one step. The aim of the present mini-review is to highlight the importance of the one-pot domino reaction for the synthesis of condensed azepines. This review also presents research on this subject from the past two decades.

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