Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted
Inflammatory Intervention

Sagar      Das; Tuhin      Mukherjee; Satyajit      Mohanty; Nikita      Nayak; Payel      Mal; Sumel      Ashique; Radheshyam      Pal; Sourav      Mohanto; Himanshu      Sharma

doi:10.2174/0113892010301469240409082212

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Abstract

This detailed review disclosed the NF-κB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms involving inhibitory proteins like IκB and p100 within the NF-κB signaling cascade. Disruption of the pathway is important in uncontrolled inflammation and immune disorders. This study extensively describes the role connections of canonical and non-canonical signaling pathways of NF-κB with inflammatory and cellular responses. SIRT1 belongs to the class III histone deacetylase, via RelA/p65 deacetylation, it regulates the activity of NF-κB, closely linked with the NAD+/NADH cellular ratio, influencing stress responses, aging processes, gene regulation, and metabolic pathways. This detailed study reveals SIRT1 as a crucial avenue for uncovering the role of imbalanced NF-κB in diabetes, obesity, and atherosclerosis. This study provides valuable knowledge about the therapeutic targets of inflammatory disorders.

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DOI https://dx.doi.org/10.2174/0113892010301469240409082212	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316

Current Pharmaceutical Biotechnology

Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention

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