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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Facile Synthesis of 2-Substituted Quinazolines via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Coupling

Author(s): Shulei Wu, Qianqian Lei, Zaoduan Wu, Huifang Xie, Chen Zhang, Yu Ye, Meiling Yi, Mingsheng Chen, Hao Xu* and Zehua Yang*

Volume 28, Issue 4, 2024

Published on: 12 March, 2024

Page: [305 - 318] Pages: 14

DOI: 10.2174/0113852728290175240213050011

Price: $65

Abstract

This study aims to develop a practical and facile one-pot synthesis of 2- substituted quinazolines. Using a commercially available and structurally simple ruthenium( II) complex as the catalyst to synthesize a series of quinazoline derivatives via acceptorless dehydrogenative coupling. The mechanism of this reaction was explored by control reaction and DFT calculation. This protocol offers access to a diverse array of quinazoline derivatives (52 examples) in moderate to excellent yields (29%-98%). In summary, we have developed an efficient one-pot ruthenium (II)-catalyzed ADC synthesis of quinazoline under an air atmosphere. The reaction only produces hydrogen and water as by-products, serving as a sustainable and atom-efficient synthetic approach.

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