In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways

Title:In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways

Volume: 25

Author(s): Chun-Xia Wang*, Hsiang-Hung Cheng, Mei Luo and Jing-Rong Jiang

Affiliation:

• Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610075, China

Abstract: Rheumatoid arthritis (RA) is an autoimmune disease with no known cure that results in joint deformities and dysfunction, significantly impacting the quality of life of patients. The abnormal NF-ＫB signaling pathway in RA has emerged as a crucial research area for the development of RA therapies, with non-coding RNAs (ncRNAs) serving as a potentially meaningful avenue to regulate it. Thus, understanding the role of ncRNAs in RA and the identification of new therapeutic targets have become pressing issues in the field. In this review, we aim to summarize recent studies on ncRNAs that regulate the NF-ＫB signaling pathway in RA, including miRNAs, lncRNAs, and circRNAs, as well as the mechanisms by which drugs modulate NF-Ｋ B activity. By highlighting these recent advances, we hope to promote further research into targeted RA therapy and provide novel directions and ideas for researchers in the field.

Cite this article as:

Wang Chun-Xia*, Cheng Hsiang-Hung, Luo Mei and Jiang Jing-Rong, In Rheumatoid Arthritis, A Review of ncRNAs Related to NF-κB Signaling Pathways, Current Pharmaceutical Biotechnology 2024; 25 () . https://dx.doi.org/10.2174/0113892010262829240214061103