Generic placeholder image

Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Meta-Analysis

The Prognostic Value and Clinical Significance of lncRNA SNHG5 Expression in Patients with Multiple Malignancies: A Bioinformatic and Meta-Analysis

In Press, (this is not the final "Version of Record"). Available online 23 February, 2024
Author(s): Mehran Pashirzad and Amirhossein Sahebkar*
Published on: 23 February, 2024

DOI: 10.2174/0115680096282865240111055640

Price: $95

Abstract

Background: Long non-coding RNA small nucleolar RNA host gene 5 (lncRNA SNHG5) has been identified as both a promising target for treatment and a predictor of prognosis in diverse types of cancer. The objective of this study was to assess whether lncRNA SNHG5 expression can be utilized as a prognostic biomarker for human cancer.

Methods: To ensure a thorough search of the literature for relevant English studies published before July 2023, several databases were searched, including PubMed, Web of Science, ProQuest, Cochrane Library, and Google Scholar. The study evaluated the impact of lncRNA SNHG5 on the overall survival (OS) of cancer by calculating the pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CIs). To further confirm the accuracy of the findings, the study investigated the expression profile and prognostic significance of lncRNA SNHG5 through the use of GenomicScape, OncoLnc, Kaplan-Meier plotter, and GEPIA databases.

Results: In this study, 995 patients were examined across a total of fourteen original studies. The findings indicated that there was a significant relationship between heightened lncRNA SNHG5 expression and reduced OS, as evidenced by both univariate and multivariate analyses (HR = 1.89; 95% CI, 1.44-2.49; p < 0.001; HR = 3.97; 95% CI, 1.80-8.73; p < 0.001, respectively). Pooled OR analysis showed a significant association between over-expression of lncRNA SNHG5 with advanced histological grade (OR = 0.28; 95% CI, 0.11-0.71; p = 0.007), present lymph node metastasis (LNM; OR = 4.28; 95% CI, 2.47-7.43; p < 0.001), and smoking history (OR = 0.27; 95% CI, 0.15-0.49; p < 0.001). Bioinformatic databases confirmed that elevated SNHG5 expression was significantly linked to poor prognosis in cancer patients, including colorectal cancer (CRC), acute myeloid leukemia (AML), and esophageal adenocarcinoma (ESAD), and a longer OS in patients with uterine corpus endometrial carcinoma (UCEC).

Conclusion: These results suggest that lncRNA SNHG5 may serve as an adverse prognostic biomarker in several human cancers. Further investigations are needed to better understand the underlying mechanisms that link lncRNA SNHG5 to multiple malignancies.

[1]
Hassanpour, SH; Dehghani, M Review of cancer from perspective of molecular. J. Cancer Res. Pract., 2017, 4(4), 127-139.
[http://dx.doi.org/10.1016/j.jcrpr.2017.07.001]
[2]
Siegel, R; Ma, J; Zou, Z.; Jemal, A. Cancer statistics. CA Cancer J Clin., 2014, 64(1), 9-29.
[3]
Ponting, C.P.; Belgard, T.G. Transcribed dark matter: Meaning or myth? Hum. Mol. Genet., 2010, 19(R2), R162-R168.
[http://dx.doi.org/10.1093/hmg/ddq362] [PMID: 20798109]
[4]
Ghorbanzadeh, Z.; Hamid, R.; Jacob, F.; Asadi, S.; Salekdeh, G.H.; Ghaffari, M.R. Non-coding RNA: Chief architects of drought-resilient roots. Rhizosphere, 2022, 23100572
[http://dx.doi.org/10.1016/j.rhisph.2022.100572]
[5]
Fathullahzadeh, S; Mirzaei, H; Honardoost, MA; Sahebkar, A; Salehi, M Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia. Cancer Gene Ther. , 2016, 23(10), 327-332.
[http://dx.doi.org/10.1038/cgt.2016.34]
[6]
Mirzaei, HR; Sahebkar, A; Mohammadi, M; Yari, R; Salehi, H; Jafari, MH Circulating micrornas in hepatocellular carcinoma: Potential diagnostic and prognostic biomarkers. Curr Pharm Des., 2016, 22(34), 5257-5269.
[7]
Liu, S.J.; Dang, H.X.; Lim, D.A.; Feng, F.Y.; Maher, C.A. Long noncoding RNAs in cancer metastasis. Nat. Rev. Cancer, 2021, 21(7), 446-460.
[http://dx.doi.org/10.1038/s41568-021-00353-1] [PMID: 33953369]
[8]
Borkowska, E.M.; Kutwin, P.; Rolecka, D.; Konecki, T.; Borowiec, M.; Jabłonowski, Z. Clinical value of microRNA-19a-3p and microRNA-99a-5p in bladder cancer. Arch. Med. Sci., 2023, 19(3), 694-702.
[PMID: 37313204]
[9]
Guo, X.; Liu, N.; Liu, M. Long non-coding RNA LINC00336 as an independent prognostic indicator and an oncogenic lncRNA in bladder cancer. Arch. Med. Sci., 2023, 19(2), 478-487.
[http://dx.doi.org/10.5114/aoms.2019.89661] [PMID: 37034517]
[10]
Han, C.; Yang, Y.; Guo, L.; Guan, Q.; Ruan, S. The expression of long non-coding RNA HOTAIR in advanced hepatocellular carcinoma and its prognostic correlation with sunitinib therapy. Arch. Med. Sci., 2022, 18(1), 71-78.
[PMID: 35154527]
[11]
Li, H.; Lin, X.; Li, C.; Li, J.; Xu, X.; Meng, D.; Zheng, S. MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2. Arch. Med. Sci., 2023, 19(1), 151-159.
[http://dx.doi.org/10.5114/aoms.2019.87812] [PMID: 36817669]
[12]
Lou, C.; Li, T. Long non-coding RNA SENCR alleviates endothelial-to-mesenchymal transition via targeting miR-126a. Arch. Med. Sci., 2023, 19(1), 180-188.
[http://dx.doi.org/10.5114/aoms.2020.97991] [PMID: 36817675]
[13]
Song, Z.; Xing, F.; Jiang, H.; He, Y.; Lv, J. Long non-coding RNA TP73-AS1 predicts poor prognosis and regulates cell proliferation and migration in cervical cancer. Arch. Med. Sci., 2022, 18(2), 523-534.
[http://dx.doi.org/10.5114/aoms.2019.87686] [PMID: 35316908]
[14]
Zhang, S.; Wang, X.; Wang, D. Long non-coding RNA LINC01296 promotes progression of oral squamous cell carcinoma through activating the MAPK/ERK signaling pathway via the miR-485-5p/PAK4 axis. Arch. Med. Sci., 2022, 18(3), 786-799.
[http://dx.doi.org/10.5114/aoms.2019.86805] [PMID: 35591837]
[15]
Salarinia, R.; Sahebkar, A.; Peyvandi, M.; Mirzaei, H.R.; Jaafari, M.R.; Riahi, M.M.; Ebrahimnejad, H. Nahand, J. S., Hadjati, J., Asrami, M. O., Fadaei, S., Salehi, R., Mirzaei, H. Epi-drugs and Epi-miRs: Moving beyond current cancer therapies. Curr. Cancer Drug Targets, 2016, 16(9), 773-788.
[http://dx.doi.org/10.2174/1568009616666151207110143]
[16]
Xue, M.; Zhuo, Y.; Shan, B. MicroRNAs, long noncoding RNAs, and their functions in human disease; Bioinformatics in MicroRNA Research, 2017, pp. 1-25.
[http://dx.doi.org/10.1007/978-1-4939-7046-9_1]
[17]
Pinkney, H.R.; Wright, B.M.; Diermeier, S.D. The lncRNA toolkit: Databases and in silico tools for lncRNA analysis. Noncoding RNA, 2020, 6(4), 49.
[http://dx.doi.org/10.3390/ncrna6040049] [PMID: 33339309]
[18]
Ahn, Y.H.; Kim, J.S. Long non-coding RNAs as regulators of interactions between cancer-associated fibroblasts and cancer cells in the tumor microenvironment. Int. J. Mol. Sci., 2020, 21(20), 7484.
[http://dx.doi.org/10.3390/ijms21207484] [PMID: 33050576]
[19]
Tu, C.; Yang, K.; Wan, L.; He, J.; Qi, L.; Wang, W.; Lu, Q.; Li, Z. The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression. Cell Prolif., 2020, 53(9)e12887
[http://dx.doi.org/10.1111/cpr.12887] [PMID: 32779318]
[20]
Schmitt, A.M.; Chang, H.Y. Long noncoding RNAs in cancer pathways. Cancer Cell, 2016, 29(4), 452-463.
[http://dx.doi.org/10.1016/j.ccell.2016.03.010] [PMID: 27070700]
[21]
Li, Y.; Guo, D.; Zhao, Y.; Ren, M.; Lu, G.; Wang, Y.; Zhang, J.; Mi, C.; He, S.; Lu, X. Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-26a-5p/GSK3β signal pathway. Cell Death Dis., 2018, 9(9), 888.
[http://dx.doi.org/10.1038/s41419-018-0882-5] [PMID: 30166525]
[22]
Li, J.; Sun, C.K. Long noncoding RNA SNHG5 is up-regulated and serves as a potential prognostic biomarker in acute myeloid leukemia. Eur. Rev. Med. Pharmacol. Sci., 2018, 22(11), 3342-3347.
[PMID: 29917184]
[23]
Li, X.; Du, Y.; Wang, Y. The value of LncRNA SNHG5 as a marker for the diagnosis and prognosis of gastric cancer. Am. J. Transl. Res., 2021, 13(5), 5420-5427.
[PMID: 34150139]
[24]
Ichigozaki, Y.; Fukushima, S.; Jinnin, M.; Miyashita, A.; Nakahara, S.; Tokuzumi, A.; Yamashita, J.; Kajihara, I.; Aoi, J.; Masuguchi, S.; Zhongzhi, W.; Ihn, H. Serum long non-coding RNA, snoRNA host gene 5 level as a new tumor marker of malignant melanoma. Exp. Dermatol., 2016, 25(1), 67-69.
[http://dx.doi.org/10.1111/exd.12868] [PMID: 26440365]
[25]
Damas, N.D.; Marcatti, M.; Côme, C.; Christensen, L.L.; Nielsen, M.M.; Baumgartner, R.; Gylling, H.M.; Maglieri, G.; Rundsten, C.F.; Seemann, S.E.; Rapin, N.; Thézenas, S.; Vang, S.; Ørntoft, T.; Andersen, C.L.; Pedersen, J.S.; Lund, A.H. SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nat. Commun., 2016, 7(1), 13875.
[http://dx.doi.org/10.1038/ncomms13875] [PMID: 28004750]
[26]
Qin, Y.; Sun, W.; Wang, Z.; Dong, W.; He, L.; Zhang, T.; Lv, C.; Zhang, H. RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma. Cell Death Dis., 2022, 13(3), 270.
[http://dx.doi.org/10.1038/s41419-022-04728-6] [PMID: 35338124]
[27]
Li, Z; Wu, Y; Zhang, C; Dai, S; Wei, S; Zhao, R LncRNA SNHG5 suppresses cell migration and Invasion of human lung adenocarcinoma via regulation of epithelial-mesenchymal transition. J. Oncol., 2023, 2023
[http://dx.doi.org/10.1155/2023/3335959]
[28]
Ju, C.; Zhou, R.; Sun, J.; Zhang, F.; Tang, X.; Chen, K.K.; Zhao, J.; Lan, X.; Lin, S.; Zhang, Z.; Lv, X.B. LncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis. Cancer Cell Int., 2018, 18(1), 141.
[http://dx.doi.org/10.1186/s12935-018-0641-9] [PMID: 30250399]
[29]
Gao, J.; Zeng, K.; Liu, Y.; Gao, L.; Liu, L. LncRNA SNHG5 promotes growth and invasion in melanoma by regulating the miR-26a-5p/TRPC3 pathway. OncoTargets Ther., 2018, 12, 169-179.
[http://dx.doi.org/10.2147/OTT.S184078] [PMID: 30636880]
[30]
Zhang, M.; Li, Y.; Wang, H.; Yu, W.; Lin, S.; Guo, J. LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5. Cancer Biol. Ther., 2019, 20(4), 524-536.
[http://dx.doi.org/10.1080/15384047.2018.1537579] [PMID: 30395767]
[31]
Zhao, L.; Han, T.; Li, Y.; Sun, J.; Zhang, S.; Liu, Y.; Shan, B.; Zheng, D.; Shi, J. The IncRNA SNHG5/miR-32 axis regulates gastric cancer cell proliferation and migration by targeting KLF4. FASEB J., 2017, 31(3), 893-903.
[http://dx.doi.org/10.1096/fj.201600994R] [PMID: 27871067]
[32]
He, B.; Bai, Y.; Kang, W.; Zhang, X.; Jiang, X. LncRNA SNHG5 regulates imatinib resistance in chronic myeloid leukemia via acting as a CeRNA against MiR-205-5p. Am. J. Cancer Res., 2017, 7(8), 1704-1713.
[PMID: 28861326]
[33]
Han, W.; Shi, J.; Cao, J.; Dong, B.; Guan, W. Latest advances of long non-coding RNA SNHG5 in human cancers. OncoTargets Ther., 2020, 13, 6393-6403.
[http://dx.doi.org/10.2147/OTT.S252750] [PMID: 32753882]
[34]
Li, Y.H.; Hu, Y.Q.; Wang, S.C.; Li, Y.; Chen, D.M. LncRNA SNHG5: A new budding star in human cancers. Gene, 2020, 749144724
[http://dx.doi.org/10.1016/j.gene.2020.144724] [PMID: 32360843]
[35]
Xing, X.; Xu, T.; Liu, B.; Guo, Q. LncRNA SNHG5 can regulate the proliferation and migration of diffuse large B cell lymphoma progression via targeting miR-181-5p/XIAP. J. Cancer, 2022, 13(3), 784-792.
[http://dx.doi.org/10.7150/jca.60521] [PMID: 35154447]
[36]
Xiao, X; Xu, J; Sheng, X; Wang, C; Dong, J; Shi, X. Tobacco nicotine promote TRAIL resistance in lung cancer by SNHG5. Exp Ther Med., 2022, 25(3), 131.
[http://dx.doi.org/10.21203/rs.3.rs-1651202/v1]
[37]
Zhang, L.; Wu, X.; Li, Y.; Teng, X.; Zou, L.; Yu, B. LncRNA SNHG5 promotes cervical cancer progression by regulating the miR-132/SOX4 pathway. Autoimmunity, 2021, 54(2), 88-96.
[http://dx.doi.org/10.1080/08916934.2020.1864731] [PMID: 33622094]
[38]
Ying, X.; Zhang, W.; Fang, M.; Wang, C.; Han, L.; Yang, C. LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia. Inflamm. Res., 2020, 69(6), 607-618.
[http://dx.doi.org/10.1007/s00011-020-01345-x] [PMID: 32266420]
[39]
Ma, Z.; Xue, S.; Zeng, B.; Qiu, D. lncRNA SNHG5 is associated with poor prognosis of bladder cancer and promotes bladder cancer cell proliferation through targeting p27. Oncol. Lett., 2018, 15(2), 1924-1930.
[PMID: 29434891]
[40]
Wang, Z.; Wang, Z.; Liu, J.; Yang, H. Long non-coding RNA SNHG5 sponges miR-26a to promote the tumorigenesis of osteosarcoma by targeting ROCK1. Biomed. Pharmacother., 2018, 107, 598-605.
[http://dx.doi.org/10.1016/j.biopha.2018.08.025] [PMID: 30114643]
[41]
Wei, S.; Sun, S.; Zhou, X.; Zhang, C.; Li, X.; Dai, S.; Wang, Y.; Zhao, L.; Shan, B. SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer. Carcinogenesis, 2021, 42(2), 315-326.
[http://dx.doi.org/10.1093/carcin/bgaa110] [PMID: 33095847]
[42]
Liu, D.; Wang, Y.; Zhao, Y.; Gu, X. LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis. BMC Cancer, 2020, 20(1), 178.
[http://dx.doi.org/10.1186/s12885-020-6662-5] [PMID: 32131767]
[43]
Kassambara, A.; Rème, T.; Jourdan, M.; Fest, T.; Hose, D.; Tarte, K.; Klein, B. GenomicScape: An easy-to-use web tool for gene expression data analysis. Application to investigate the molecular events in the differentiation of B cells into plasma cells. PLOS Comput. Biol., 2015, 11(1)e1004077
[http://dx.doi.org/10.1371/journal.pcbi.1004077] [PMID: 25633866]
[44]
Anaya, J. OncoLnc: Linking TCGA survival data to mRNAs, miRNAs, and lncRNAs. PeerJ Comput. Sci., 2016, 2e67
[http://dx.doi.org/10.7717/peerj-cs.67]
[45]
Tang, Z.; Li, C.; Kang, B.; Gao, G.; Li, C.; Zhang, Z. GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res., 2017, 45(W1), W98-W102.
[http://dx.doi.org/10.1093/nar/gkx247] [PMID: 28407145]
[46]
Lánczky, A.; Győrffy, B. Web-based survival analysis tool tailored for medical research (KMplot): Development and implementation. J. Med. Internet Res., 2021, 23(7)e27633
[http://dx.doi.org/10.2196/27633] [PMID: 34309564]
[47]
Zhao, L.; Guo, H.; Zhou, B.; Feng, J.; Li, Y.; Han, T.; Liu, L.; Li, L.; Zhang, S.; Liu, Y.; Shi, J.; Zheng, D. Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol. Oncogene, 2016, 35(44), 5770-5780.
[http://dx.doi.org/10.1038/onc.2016.110] [PMID: 27065326]
[48]
Elsayed, M.; Abdelrahim, M. The latest advancement in pancreatic ductal adenocarcinoma therapy: A review article for the latest guidelines and novel therapies. Biomedicines, 2021, 9(4), 389.
[http://dx.doi.org/10.3390/biomedicines9040389] [PMID: 33917380]
[49]
Bhan, A.; Soleimani, M.; Mandal, S.S. Long noncoding RNA and cancer: A new paradigm. Cancer Res., 2017, 77(15), 3965-3981.
[http://dx.doi.org/10.1158/0008-5472.CAN-16-2634] [PMID: 28701486]
[50]
Wang, X.; Tong, Y.; Xun, T.; Feng, H.; Lei, Y.; Li, Y. Functions, mechanisms, and therapeutic implications of noncoding RNA in acute myeloid leukemia; Fundamental Research, 2023.
[http://dx.doi.org/10.1016/j.fmre.2023.04.012]
[51]
Akshaya, R.L.; Rohini, M.; Selvamurugan, N. Regulation of breast cancer progression by noncoding RNAs. Curr. Cancer Drug Targets, 2020, 20(10), 757-767.
[http://dx.doi.org/10.2174/1568009620666200712144103] [PMID: 32652909]
[52]
Kushlinskii, N.E.; Fridman, M.V.; Braga, E.A. Long non-coding RNAs as competitive endogenous RNAs in osteosarcoma. Mol. Biol., 2020, 54(5), 776-801.
[PMID: 33009789]
[53]
Popławski, P.; Bogusławska, J.; Hanusek, K.; Piekiełko-Witkowska, A. Nucleolar proteins and non-coding RNAs: Roles in renal cancer. Int. J. Mol. Sci., 2021, 22(23), 13126.
[http://dx.doi.org/10.3390/ijms222313126] [PMID: 34884928]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version279msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[21:18:32] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[21:18:32] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[21:18:32] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[21:18:32] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[21:18:32] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (97.09ms)time
  • Application (182ms)time
  • 1 x Application (65.15%)
    182ms
    1 x Booting (34.85%)
    97.09ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    31 statements were executed, 4 of which were duplicates, 27 unique. Show only duplicated102ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316674267','',1,1740345512,1740345512) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740345512
      980μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316674267','/article/138740',1,1740345512,1740345512)
      200μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316674267 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316674267) limit 1
      10.85msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 316674267
      • 1: 316674267
      • 2: 316674267
      • 3: 316674267
      • 4: 316674267
      • 5: 316674267
      • 6: 316674267
      • 7: 316674267
      • 8: 316674267
      • 9: 316674267
      • 10: 316674267
      • 11: 316674267
      • 12: 316674267
      • 13: 316674267
      • 14: 316674267
      • 15: 316674267
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=138740
      720μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 7 limit 1
      950μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 7
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=7) and sj.journal_id!=7 group by `j`.`nid`) as `aggregate_table`
      1.02msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=7) and sj.journal_id!=7 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      820μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=7) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.46msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=7) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.29msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '138740'
      230μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 138740
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '138740'
      5.44msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 138740
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '138740' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      1.77msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 138740
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      270μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      460μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 7 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      37.49msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 7 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      9.87msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 7 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      6.4msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 138740 limit 1
      230μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 138740
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 138740 and content_type = 'article' order by status desc limit 1
      250μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 227368 limit 1
      210μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 227368
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      230μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CCDT' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      300μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CCDT
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '138740' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      360μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3459' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      320μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345512 and j.to_date >= 1740345512 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3459) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345512 and j.to_date >= 1740345512 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3459) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316674267 and j.to_ip >=316674267 )) and ((j.from_date <= 1740345512 and j.to_date >= 1740345512 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3459)
      14.41msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      260μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      220μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 138740 limit 1
      2.44msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 138740
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 7 and `b`.`banner_from_date` <= 1740345512 and `b`.`banner_to_date` >= 1740345512 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.21msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 7
      • 3: 1740345512
      • 4: 1740345512
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 7 and `b`.`banner_from_date` <= 1740345512 and `b`.`banner_to_date` >= 1740345512 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 7
      • 3: 1740345512
      • 4: 1740345512
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='78c2f1438c385f8f688397c6fff4cd71'
      210μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        IyIkkvMKUA3c2uATscONLKWY0Wl0EptM2UavZscY
        uc_cart_id
        78c2f1438c385f8f688397c6fff4cd71
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/138740" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/138740
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Sun, 23 Feb 2025 21:18:32 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkxLN3lieS84emlwZjBUZ1RxNGlJcHc9PSIsInZhbHVlIjoiSU1uODNpTGFMME9sSVVHaDlNbnR2clBCOTZTN3dIMmpXR3ZyalFJRnBwZmFFYjA4SjVvTjhWZzgzcnFqT0RoeDhFbmdQOXdqbi9yZTEyUFd1SG1uQ2ZVeU5DemZHS2xmN1h1MTZ4QUhCSGdxY3hCcHh3Ky9VdXovaGtIeElhNVciLCJtYWMiOiJjN2I3NjJhMDE3N2NkMTc4NWQyNDM1ZGNkNjRlZjA3YjZkMTUwNTNlNWY2MDI3YWQ2MTY5MzZiYWI3Y2M1ZjJiIiwidGFnIjoiIn0%3D; expires=Wed, 26 Feb 2025 09:18:32 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6IkxLN3lieS84emlwZjBUZ1RxNGlJcHc9PSIsInZhbHVlIjoiSU1uODNpTGFMME9sSVVHaDlNbnR2clBCOTZTN3dIMmpXR3ZyalFJRnBwZmFFYjA4SjVvTjhWZzgzcnFqT0RoeDhFbmdQO" 1 => "alphaeurekaselectnet_session=eyJpdiI6InRpR2dHeXdicGt6Nk9TSUdwdUs3Qmc9PSIsInZhbHVlIjoiT0xqaU5LZVlIZzJjbFJxdWx5eG5tUzc1REpzTzJJeUhaT1VpQzgvMEhpMW5kTHgxR1hYcFZUQVhhOGFFQ3R1c05JNFdYNk0xR0VhTjQ3NXBLWVVKTWUzSDhCdDFTZG1sZmJqOC9nK0ZjSCsxRCtqRUpSUEZQbDg1ajVFT0pnRk8iLCJtYWMiOiIxYWQ2OTcwZGQzNThmNWYyYWY0YWNjZmExZTE5MGNmNjQ4Zjk2MzVkMTQzMzhlYThlM2ExYTFlZDY2NTZjNTM5IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6InRpR2dHeXdicGt6Nk9TSUdwdUs3Qmc9PSIsInZhbHVlIjoiT0xqaU5LZVlIZzJjbFJxdWx5eG5tUzc1REpzTzJJeUhaT1VpQzgvMEhpMW5kTHgxR1hYcFZUQVh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkxLN3lieS84emlwZjBUZ1RxNGlJcHc9PSIsInZhbHVlIjoiSU1uODNpTGFMME9sSVVHaDlNbnR2clBCOTZTN3dIMmpXR3ZyalFJRnBwZmFFYjA4SjVvTjhWZzgzcnFqT0RoeDhFbmdQOXdqbi9yZTEyUFd1SG1uQ2ZVeU5DemZHS2xmN1h1MTZ4QUhCSGdxY3hCcHh3Ky9VdXovaGtIeElhNVciLCJtYWMiOiJjN2I3NjJhMDE3N2NkMTc4NWQyNDM1ZGNkNjRlZjA3YjZkMTUwNTNlNWY2MDI3YWQ2MTY5MzZiYWI3Y2M1ZjJiIiwidGFnIjoiIn0%3D; expires=Wed, 26-Feb-2025 09:18:32 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkxLN3lieS84emlwZjBUZ1RxNGlJcHc9PSIsInZhbHVlIjoiSU1uODNpTGFMME9sSVVHaDlNbnR2clBCOTZTN3dIMmpXR3ZyalFJRnBwZmFFYjA4SjVvTjhWZzgzcnFqT0RoeDhFbmdQO" 1 => "alphaeurekaselectnet_session=eyJpdiI6InRpR2dHeXdicGt6Nk9TSUdwdUs3Qmc9PSIsInZhbHVlIjoiT0xqaU5LZVlIZzJjbFJxdWx5eG5tUzc1REpzTzJJeUhaT1VpQzgvMEhpMW5kTHgxR1hYcFZUQVhhOGFFQ3R1c05JNFdYNk0xR0VhTjQ3NXBLWVVKTWUzSDhCdDFTZG1sZmJqOC9nK0ZjSCsxRCtqRUpSUEZQbDg1ajVFT0pnRk8iLCJtYWMiOiIxYWQ2OTcwZGQzNThmNWYyYWY0YWNjZmExZTE5MGNmNjQ4Zjk2MzVkMTQzMzhlYThlM2ExYTFlZDY2NTZjNTM5IiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6InRpR2dHeXdicGt6Nk9TSUdwdUs3Qmc9PSIsInZhbHVlIjoiT0xqaU5LZVlIZzJjbFJxdWx5eG5tUzc1REpzTzJJeUhaT1VpQzgvMEhpMW5kTHgxR1hYcFZUQVh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "IyIkkvMKUA3c2uATscONLKWY0Wl0EptM2UavZscY" "uc_cart_id" => "78c2f1438c385f8f688397c6fff4cd71" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/138740" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-23 21:18:32GET/article/138740514311