Abstract
The protoberberines are a widespread, important group of isoquinoline alkaloids. Due to the potent pharmacological and other bioactive properties they have achieved an increasing attention in medicinal chemistry and drug research. This article will give a brief structural classification of the protoberberines and related compounds, the biosynthesis, a compilation of new alkaloids isolated during the last decade including source, structure and analytical/spectral data. The main part of the present review is focused on recent synthesis pathways to the title compounds.
Keywords: Synthesis, medicinal chemistry, isoquinoline alkaloids, Protoberberines, analytical/spectral data
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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