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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether

Author(s): Xiaoxia Mao, Yuying Zhang, Keyang Wang, Guiqin Zhao, Dejun Zhou* and Zhengguo Cui*

Volume 21, Issue 9, 2024

Published on: 29 January, 2024

Page: [784 - 789] Pages: 6

DOI: 10.2174/0115701786262911240121105544

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Abstract

In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might be developed as a new drug for the treatment of acute myeloid leukemia.

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