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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Towards Antiviral Potential of Biomolecules Derived from Adhatod avasica as Competent Natural Molecules to Treat COVID-19 Virus Variant

Author(s): Mohammad Asif*, Mohd Yusuf, Mazen Almehmadi, Ahad Amer Alsaiari, Mamdouh Allahyani, Abdulelah Aljuaid and Abdulaziz Alsharif

Volume 21, Issue 5, 2024

Published on: 23 January, 2024

Page: [466 - 477] Pages: 12

DOI: 10.2174/0115701786263427231123103651

Price: $65

Abstract

Adhatoda vasica (L.) (Acanthaceae) has essential therapeutic roles and is widely used in the indigenous medicine system or Ayurvedic system of medicine. The important goals of the present study are to report the in-silico anti-corona (COVID-19) activity of different phytochemicals present in A. vasica. This study will help to find specific bioactive compounds, and their use as anti- COVID-19 action for human welfare. A. vasica has chemical phytoconstituents with diverse pharmacological activities. These phytoconstituents have been found active against many diseases such as antibacterial, antitubercular, antivirus, antitussive, hepatoprotective, antiinflammatory, antiulcer, antiurolithiatic, abortifacient, radio modulator, cardio-protection, antidiabetic, antioxidant, anticancer, thrombolytic, antimutagenic, etc. Researchers have been lured to the use of natural and sustainable products with substantial therapeutic potential in the current climate of environmental preservation and safe use. These materials permit biological activity, safety, and compatibility with the environment. Using the SARS-CoV-2 spike receptor (6M0J), we evaluated Adhatoda vasica biomolecules for the Covid-19 variant (RBD- COV-2-S). This study is very encouraging and indicates that herbs should be studied more extensively for their therapeutic benefits.

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