The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review

Title:The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review

Volume: 25 Issue: 15

Author(s): Devesh Kapoor, Shirisha C. Chilkapalli, Bhupendra G. Prajapati*, Paul Rodriques, Ravish Patel, Sudarshan Singh*Sankha Bhattacharya

Affiliation:

• Department of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana-384012, Gujarat, India

• Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand

Abstract: Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale production. Despite recent research efforts, challenges in stability, toxicity, and regulatory concerns have limited the commercial availability of LNP-based products. This review explores the applications, administration routes, challenges, and future directions of LNPs in delivering biopharmaceuticals.

Cite this article as:

Kapoor Devesh, Chilkapalli C. Shirisha, Prajapati G. Bhupendra*, Rodriques Paul, Patel Ravish, Singh Sudarshan*, Bhattacharya Sankha, The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review, Current Pharmaceutical Biotechnology 2024; 25 (15) . https://dx.doi.org/10.2174/0113892010268824231122041237