Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders

Title:Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders

Volume: 25 Issue: 13

Author(s): Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Saeideh Momtaz, Faezeh Niazi Shahraki, Nadia Zandi, Benyamin Pazoki, Mohammad Hosein Farzaei*, Mehdi Ghasemi, Mohammad Abdollahi and Amir Hossein Abdolghaffari*

Affiliation:

• Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
• Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

• Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
• Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Abstract:

Background: Visceral hypersensitivity (VH) is an overreaction of the gastrointestinal (GI) tract to various stimuli and is characterized by hyperalgesia and/or allodynia. VH contributes to the etiology of many GI dysfunctions, particularly irritable bowel syndrome (IBS). Although the exact mechanisms underlying VH are yet to be found, inflammation and oxidative stress, psychosocial factors, and sensorimotor alterations may play significant roles in it.

Objective: In this review, we provide an overview of VH and its pathophysiological function in GI disorders. Adverse effects of synthetic drugs may make herbal agents a good candidate for pain management. Therefore, in this review, we will discuss the efficacy of herbal agents in the management of VH with a focus on their anti-inflammatory and antioxidant potentials.

Methods: Data were extracted from clinical and animal studies published in English between 2004 and June, 2020, which were collected from PubMed, Google Scholar, Scopus, and Cochrane Library.

Results: Overall, Radix, Melissia, Glycyrrhizae, Mentha, and Liquorice were the most efficient herbals for VH management in IBS and dyspepsia, predominantly through modulation of the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and suppression of 5- hydroxytryptamine 3 (5-HT₃) or the serotonin receptors.

Conclusion: Considering the positive effects of herbal formulations in VH management, further research on novel herbal and/or herbal/chemical preparations is warranted.

Cite this article as:

Lashgari Naser-Aldin, Momeni Roudsari Nazanin, Momtaz Saeideh, Niazi Shahraki Faezeh, Zandi Nadia, Pazoki Benyamin, Farzaei Hosein Mohammad*, Ghasemi Mehdi, Abdollahi Mohammad and Abdolghaffari Amir Hossein*, Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders, Current Pharmaceutical Biotechnology 2024; 25 (13) . https://dx.doi.org/10.2174/0113892010261502231102040149