Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles

Title:Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles

Volume: 21

Author(s): Fatemeh Shahidi, M. Reza Naimi-Jamal*, Azizollah Habibi and Mohammad G. Dekamin

Affiliation:

• Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of Science and Technology, 16846-13114, Tehran, Iran

Abstract:

Introduction: Zeolitic imidazolate frameworks (ZIFs) play a crucial role among metalorganic frameworks due to their highly desirable properties, including high surface area, appropriate pore size, and excellent thermal and chemical stability.

Method: In this study, ZIF-8 loaded with aspirin and coated using pectin (ZIF-8/Asp@Pectin) was utilized as a suitable and effective platform for the drug delivery system. The preparation of this coated MOF followed environmentally friendly methods, and aspirin was successfully loaded.

Result: Characterization of the obtained ZIF-8/Asp@Pectin was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), Fourier Transform Infrared (FT-IR) spectroscopy, and BET analysis.

Conclusion: The release of aspirin from ZIF-8/Asp@Pectin was studied using UV–Vis spectroscopy at 258 nm under in vitro conditions in HCl and PBS buffer solutions.

Cite this article as:

Shahidi Fatemeh, Naimi-Jamal M. Reza*, Habibi Azizollah and Dekamin G. Mohammad, Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles, Current Drug Delivery 2024; 21 () . https://dx.doi.org/10.2174/0115672018288328240109064308