DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System

Title: DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System

Volume: 16 Issue: 7

Author(s): Guido Frosina

Affiliation:

Keywords: Stem cells, differentiation, DNA repair, CD133, cancer

Abstract: Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.

Cite this article as:

Frosina Guido, DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System, Current Medicinal Chemistry 2009; 16 (7) . https://dx.doi.org/10.2174/092986709787549253