Login Register Cart 0
Generic placeholder image

Current Drug Safety

Editor-in-Chief

ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Unveiling the Latest Breakthroughs: A Comprehensive Review of the Therapeutic Activity and Safety Profile of Aloe vera

Author(s): Alimuddin Saifi*, Alok Sharma, Anurag Chaudhary, Nazia Siddiqui, Vrish Dhwaj Ashwlayan and Bhuwanendra Singh

Volume 19, Issue 4, 2024

Published on: 09 January, 2024

Page: [407 - 416] Pages: 10

DOI: 10.2174/0115748863274759231221093309

Price: $65

conference banner
Abstract

The use of herbal drugs as alternative and complementary medicine has increased in popularity, raising concerns about their safety profile. Aloe vera, a plant with diverse therapeutic properties, has been extensively used for centuries. This review aims to assess the therapeutic activity and safety profile of Aloe vera. A comprehensive literature search was conducted to gather relevant information from various biomedical databases. The chemical composition, mechanism of action, and therapeutic activities of Aloe vera were analyzed. Aloe vera contains numerous active components such as vitamins, enzymes, minerals, sugars, lignin, saponins, and anthraquinones. Its mechanisms of action involve collagen synthesis, anti-inflammatory effects, immune modulation, laxative properties, and antiviral activity. Aloe vera has demonstrated potential therapeutic benefits in wound healing, diabetes management, liver and kidney protection, and glycemic control. However, it is essential to consider potential side effects, such as skin irritation and allergic reactions. This review provides evidence-based information to improve patient safety and promote informed decisions regarding the use of Aloe vera as a therapeutic agent.

Next »
Graphical Abstract

[1]
Tyler: The honest herbal: a sensible guide to the... - Google Scholar. 2023. Available from: https://scholar.google.com/scholar_lookup?title=The+honest+herbal:+A+sensible+guide+to+the+use+of+herbs+and+related+remedies&author=V+Tyler&publication_year=1993& Accessed: Jun. 28
[2]
Ardalan M-R, Rafieian-Kopaei M. Is the safety of herbal medicines for kidneys under question? J Nephropharmacol 2013; 2(2): 11. Available: https://pmc/articles/PMC5297543/ Accessed: May 25, 2023
[3]
Kavita Rai, Nandan N, Nandan N. Aloe vera – Nature’s power. J ayurveda integr med sci 2016; 1(2): 43-9.
[http://dx.doi.org/10.21760/jaims.v1i2.3664]
[4]
Shriwas HK, Singh SP. Analytical study of different samples of aloe vera juice. J ayurveda integr med sci 2023; 8(4): 37-45.
[http://dx.doi.org/10.21760/jaims.8.4.6]
[5]
Lanka S. A review on aloe vera-the wonder medicinal plant. J Drug Deliv Ther 2018; 8(5-s): 94-9.
[http://dx.doi.org/10.22270/jddt.v8i5-s.1962]
[6]
Manvitha K, Bidya B, Karkala Manvitha C. Aloe vera: A wonder plant its history, cultivation and medicinal uses, ~ 85 ~. J Pharmacogn Phytochem 2014; 2(5): 85-8.
[7]
Sajjad A, Subhani Sajjad S. Aloe vera: An ancient herb for modern dentistry—a literature review. J Dent Surg 2014; 2014: 1-6.
[http://dx.doi.org/10.1155/2014/210463]
[8]
Baruah A, Bordoloi M, Deka Baruah HP. Aloe vera: A multipurpose industrial crop. Ind Crops Prod 2016; 94: 951-63.
[http://dx.doi.org/10.1016/j.indcrop.2016.08.034]
[9]
Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol 2008; 53(4): 163-6.
[http://dx.doi.org/10.4103/0019-5154.44785] [PMID: 19882025]
[10]
Ekor M. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol 2014; 4: 177.
[http://dx.doi.org/10.3389/fphar.2013.00177] [PMID: 24454289]
[11]
Pushparaj P, Tan CH, Tan BKH. Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats. J Ethnopharmacol 2000; 72(1-2): 69-76.
[http://dx.doi.org/10.1016/S0378-8741(00)00200-2] [PMID: 10967456]
[12]
Kameswara Rao B, Kesavulu MM, Giri R, Appa Rao C. Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook. fruit powder in alloxan-diabetic rats. J Ethnopharmacol 1999; 67(1): 103-9.
[http://dx.doi.org/10.1016/S0378-8741(99)00004-5] [PMID: 10616966]
[13]
Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012; 2(4): 320-30.
[http://dx.doi.org/10.1016/S2221-1691(12)60032-X] [PMID: 23569923]
[14]
Shin S, Kim S, Oh HE, et al. Dietary aloe QDM complex reduces obesity-induced insulin resistance and adipogenesis in obese mice fed a high-fat diet. Immune Netw 2012; 12(3): 96-103.
[http://dx.doi.org/10.4110/in.2012.12.3.96] [PMID: 22916045]
[15]
Beppu H, Nagamura Y, Fujita K. Hypoglycaemic and antidiabetic effects in mice of Aloe arborescens Miller var. natalensis Berger. Phytother Res 1993; 7(7): S37-42.
[http://dx.doi.org/10.1002/ptr.2650070713]
[16]
Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996; 3(3): 245-8.
[http://dx.doi.org/10.1016/S0944-7113(96)80061-4] [PMID: 23195078]
[17]
Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: A randomized controlled-trial. J Diabetes Metab Disord 2015; 14(1): 22.
[http://dx.doi.org/10.1186/s40200-015-0137-2] [PMID: 25883909]
[18]
Maan AA, Nazir A, Khan MKI, et al. The therapeutic properties and applications of Aloe vera: A review. J Herb Med 2018; 12: 1-10.
[http://dx.doi.org/10.1016/j.hermed.2018.01.002]
[19]
Atherton P. The essential aloe vera: The actions and the evidence. 1st ed. Mill enterprises paperback 1997; 1.
[20]
Shelton RM. Aloe Vera. Int J Dermatol 1991; 30(10): 679-83.
[http://dx.doi.org/10.1111/j.1365-4362.1991.tb02607.x] [PMID: 1823544]
[21]
Selamoglu Z. Aloe vera: A miracle plant with its wide-ranging applications. Pharm Pharmacol Int J 2018; 6(1)
[http://dx.doi.org/10.15406/ppij.2018.06.00144]
[22]
Saleem A, Naureen I, Naeem M, Murad HS, Maqsood S, Tasleem G. Aloe vera gel effect on skin and pharmacological properties. Sch int j anat physiol 2022; 5(1): 1-8.
[http://dx.doi.org/10.36348/sijap.2022.v05i01.001]
[23]
Rajasekaran S, Sivagnanam K, Subramanian S. Mineral contents of aloe vera leaf gel and their role on streptozotocin-induced diabetic rats. Biol Trace Elem Res 2005; 108(1-3): 185-96.
[http://dx.doi.org/10.1385/BTER:108:1-3:185] [PMID: 16327071]
[24]
Nejatzadeh-Barandozi F. Antibacterial activities and antioxidant capacity of Aloe vera. Org Med Chem Lett 2013; 3(1): 5.
[http://dx.doi.org/10.1186/2191-2858-3-5] [PMID: 23870710]
[25]
Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological update properties of aloe vera and its major active constituents. Molecules 2020; 25(6): 1324.
[http://dx.doi.org/10.3390/molecules25061324] [PMID: 32183224]
[26]
Bai Y, Niu Y, Qin S, Ma G. A new biomaterial derived from aloe vera—acemannan from basic studies to clinical application. Pharmaceutics 2023; 15(7): 1913.
[http://dx.doi.org/10.3390/pharmaceutics15071913] [PMID: 37514099]
[27]
Silva SS, Fernandes EM, Pina S, et al. 2.11 Polymers of biological origin. Compr Biomater 2017; II: 228-52.
[http://dx.doi.org/10.1016/B978-0-12-803581-8.10134-1]
[28]
Lanka S. A review on aloe vera-the wonder medicinal plant Suseela Lanka. J Drug Deliv Ther 2018.
[http://dx.doi.org/10.22270/jddt.v8i5-s.1962]
[29]
Bera Tushar Kanti. Phytochemical constituents of aloe vera and their multifunctional properties: A comprehensive review. Int J Pharm Sci Res 2018; 9(4): 416-23.
[30]
Lombardi N, Bettiol A, Crescioli G, et al. Association between anthraquinone laxatives and colorectal cancer: protocol for a systematic review and meta-analysis. Syst Rev 2020; 9(1): 19.
[http://dx.doi.org/10.1186/s13643-020-1280-5] [PMID: 31980030]
[31]
Sharma S, Sharma S. Aloe vera: An ancient herb its components and applications. J Pharmacogn Phytochem 2018; 7(6): 514-6. Available from: https://www.phytojournal.com/archives/2018.v7.i6.6208/aloe-vera-an-ancient-herb-its-components-and-applications Accessed: Jun. 28, 2023.
[32]
Upadhyay RK. Nutraceutical, therapeutic, and pharmaceutical potential of Aloe vera: A review. Int J Green Pharm 2018; 12(1): 51.
[http://dx.doi.org/10.22377/IJGP.V12I01.1601]
[33]
Brian PW. The Gibberellins as Hormones. 1966; pp. 229-66.
[http://dx.doi.org/10.1016/S0074-7696(08)60569-0]
[34]
Hamman J. Composition and applications of Aloe vera leaf gel. Molecules 2008; 13(8): 1599-616.
[http://dx.doi.org/10.3390/molecules13081599] [PMID: 18794775]
[35]
Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions. J Pharmacol Exp Ther 2000; 292(1): 114-21.
[PMID: 10604937]
[36]
Choi SM, Supeno D, Byun J-Y, et al. Chemical characteristics of aloe vera and aloe saponaria in ulsan korea. Int J BioSci Biotechnol 2016; 8(3): 109-18.
[http://dx.doi.org/10.14257/ijbsbt.2016.8.3.11]
[37]
Liu C, Cui Y, Pi F, Cheng Y, Guo Y, Qian H. Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from Aloe vera: A review. Molecules 2019; 24(8): 1554.
[http://dx.doi.org/10.3390/molecules24081554] [PMID: 31010204]
[38]
Quezada MP, Salinas C, Gotteland M, Cardemil L. Acemannan and fructans from aloe vera (aloe barbadensis miller) plants as novel prebiotics. J Agric Food Chem 2017; 65(46): 10029-39.
[http://dx.doi.org/10.1021/acs.jafc.7b04100] [PMID: 29072072]
[39]
Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem 1998; 181(1/2): 71-6.
[http://dx.doi.org/10.1023/A:1006813510959] [PMID: 9562243]
[40]
Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J Ethnopharmacol 1998; 59(3): 179-86.
[http://dx.doi.org/10.1016/S0378-8741(97)00112-8] [PMID: 9507902]
[41]
Sato Y, Ohta S, Shinoda M. [Studies on chemical protectors against radiation. XXXI. Protection effects of Aloe arborescens on skin injury induced by X-irradiation]. Yakugaku Zasshi 1990; 110(11): 876-84.
[http://dx.doi.org/10.1248/yakushi1947.110.11_876] [PMID: 2082014]
[42]
Vázquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 1996; 55(1): 69-75.
[http://dx.doi.org/10.1016/S0378-8741(96)01476-6] [PMID: 9121170]
[43]
Hutter JA, Salman M, Stavinoha WB, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 1996; 59(5): 541-3.
[http://dx.doi.org/10.1021/np9601519] [PMID: 8778246]
[44]
Farahnejad Z, Ghazanfari T, Yaraee R. Immunomodulatory effects of Aloe vera and its fractions on response of macrophages against Candida albicans. Immunopharmacol Immunotoxicol 2011; 33(4): 676-81.
[http://dx.doi.org/10.3109/08923973.2011.560158] [PMID: 21401385]
[45]
Darzi S, Paul K, Leitan S, Werkmeister JA, Mukherjee S. Immunobiology and application of aloe vera-based scaffolds in tissue engineering. Int J Mol Sci 2021; 22(4): 1708.
[http://dx.doi.org/10.3390/ijms22041708] [PMID: 33567756]
[46]
Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull 1994; 17(5): 651-3.
[http://dx.doi.org/10.1248/bpb.17.651] [PMID: 7920425]
[47]
Rahmani A, Aldebasi Y, Srikar S, Khan A, Aly S. Aloe vera: Potential candidate in health management via modulation of biological activities. Pharmacogn Rev 2015; 9(18): 120-6.
[http://dx.doi.org/10.4103/0973-7847.162118] [PMID: 26392709]
[48]
Mpiana PT, Ngbolua K-T-N, Tshibangu DST, et al. Aloe vera (L.) Burm. F. as a Potential Anti-COVID-19 Plant: A mini-review of its antiviral activity. European J Med Plants 2020; (May): 86-93.
[http://dx.doi.org/10.9734/ejmp/2020/v31i830261]
[49]
Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN. Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrob Agents Chemother 1991; 35(12): 2463-6.
[http://dx.doi.org/10.1128/AAC.35.12.2463] [PMID: 1810179]
[50]
Kim H, Lee BM. Inhibition of benzo[a]pyrene-DNA adduct formation by Aloe barbadensis Miller. Carcinogenesis 1997; 18(4): 771-6.
[http://dx.doi.org/10.1093/carcin/18.4.771] [PMID: 9111213]
[51]
Shiizaki K, Kawanishi M, Yagi T. Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor. Genes Environ 2017; 39(1): 14.
[http://dx.doi.org/10.1186/s41021-017-0076-x] [PMID: 28405246]
[52]
Singh RP, Dhanalakshmi S, Rao AR. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Phytomedicine 2000; 7(3): 209-19.
[http://dx.doi.org/10.1016/S0944-7113(00)80006-9] [PMID: 11185732]
[53]
Gupta V, Malhotra S. Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies. Ayu 2012; 33(2): 193-6.
[http://dx.doi.org/10.4103/0974-8520.105237] [PMID: 23559789]
[54]
Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis 1999; 20(8): 1637-40.
[http://dx.doi.org/10.1093/carcin/20.8.1637] [PMID: 10426820]
[55]
Cho S, Lee S, Lee MJ, et al. Dietary aloe vera supplementation improves facial wrinkles and elasticity and it increases the type i procollagen gene expression in human skin in vivo. Ann Dermatol 2009; 21(1): 6-11.
[http://dx.doi.org/10.5021/ad.2009.21.1.6] [PMID: 20548848]
[56]
Hęś M, Dziedzic K, Górecka D, Jędrusek-Golińska A, Gujska E. Aloe vera (L.) webb.: Natural sources of antioxidants – A review. Plant Foods Hum Nutr 2019; 74(3): 255-65.
[http://dx.doi.org/10.1007/s11130-019-00747-5] [PMID: 31209704]
[57]
Bajpai S. Biological importance of Aloe vera and its active constituents.Synthesis of Medicinal Agents from Plants. Elsevier 2018; pp. 177-203.
[http://dx.doi.org/10.1016/B978-0-08-102071-5.00008-8]
[58]
West DP, Zhu YF. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. Am J Infect Control 2003; 31(1): 40-2.
[http://dx.doi.org/10.1067/mic.2003.12] [PMID: 12548256]
[59]
Atherton P. Aloe vera: Magic or medicine? Nurs Stand 1998; 12(41): 49-54, 54.
[http://dx.doi.org/10.7748/ns.12.41.49.s40] [PMID: 9776900]
[60]
Hong SW, Chun J, Park S, Lee HJ, Im JP, Kim JS. Aloe vera is effective and safe in short-term treatment of irritable bowel syndrome: A systematic review and meta-analysis. J Neurogastroenterol Motil 2018; 24(4): 528-35.
[http://dx.doi.org/10.5056/jnm18077] [PMID: 30153721]
[61]
Erhabor JO, Idu M. Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats. BMC Complement Altern Med 2017; 17(1): 360.
[http://dx.doi.org/10.1186/s12906-017-1866-1] [PMID: 28693591]
[62]
Españo E, Kim J, Kim JK. Utilization of Aloe Compounds in Combatting Viral Diseases. Pharmaceuticals 2022; 15(5): 599.
[http://dx.doi.org/10.3390/ph15050599] [PMID: 35631425]
[63]
Abdal TA, Haji AR, Markus MM. Effects of aloe vera extracted on liver and kidney function changes induced by hydrogen peroxide in rats. Int j res med sci 2019; 8(1): 102.
[http://dx.doi.org/10.18203/2320-6012.ijrms20195891]
[64]
Bolkent S, Akev N, Ozsoy N, et al. Effect of Aloe vera (L.) Burm. fil. leaf gel and pulp extracts on kidney in type-II diabetic rat models. Indian J Exp Biol 2004; 42(1): 48-52.
[PMID: 15274480]
[65]
Sasso FC, Simeon V, Galiero R, et al. The number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial. Cardiovasc Diabetol 2022; 21(1): 235.
[http://dx.doi.org/10.1186/s12933-022-01674-7] [PMID: 36344978]
[66]
Yagi A, Hasegawa M, Ataka S. Possible prophylaxes of aloe vera gel to congenital heart disease: Case reports. J Gastroenterol Hepatol Res 2020; 9(6): 3357-61.
[http://dx.doi.org/10.17554/j.issn.2224-3992.2020.09.974]
[67]
Caturano A, D’Angelo M, Mormone A, et al. Oxidative stress in type 2 diabetes: Impacts from pathogenesis to lifestyle modifications. Curr Issues Mol Biol 2023; 45(8): 6651-66.
[http://dx.doi.org/10.3390/cimb45080420] [PMID: 37623239]
[68]
Rajasekaran S, Sivagnanam K, Subramanian S. Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin. J Pharm Pharmacol 2010; 57(2): 241-6.
[http://dx.doi.org/10.1211/0022357055416] [PMID: 15720789]
[69]
Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81(1): 81-100.
[http://dx.doi.org/10.1016/S0378-8741(02)00059-4] [PMID: 12020931]
[70]
Vogler BK, Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Br J Gen Pract 1999; 49(447): 823-8.
[PMID: 10885091]
[71]
Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 1996; 3(3): 241-3.
[http://dx.doi.org/10.1016/S0944-7113(96)80060-2] [PMID: 23195077]
[72]
Choudhary M, Kochhar A, Sangha J. Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics. J Food Sci Technol 2014; 51(1): 90-6.
[http://dx.doi.org/10.1007/s13197-011-0459-0] [PMID: 24426052]
[73]
Mahabady MK, Tapebur MB, Mazaheri Y, Tabandeh MR, Tabatabaei SRF. Effect of Aloe vera on the expression of nerve factors, p75 and TrkA receptors in the hippocampus of diabetic rats. Int J Morphol 2021; 39(2): 577-86.
[http://dx.doi.org/10.4067/S0717-95022021000200577]
[74]
Arora MK, Sarup Y, Tomar R, Singh M, Kumar P. Amelioration of diabetes-induced diabetic nephropathy by aloe vera: Implication of oxidative stress and hyperlipidemia. J Diet Suppl 2019; 16(2): 227-44.
[http://dx.doi.org/10.1080/19390211.2018.1449159] [PMID: 29621403]
[75]
Can A, Akev N, Ozsoy N, et al. Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol Pharm Bull 2004; 27(5): 694-8.
[http://dx.doi.org/10.1248/bpb.27.694] [PMID: 15133247]
[76]
Cui Y, Ye Q, Wang H, Li Y, Yao W, Qian H. Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol-induced hepatotoxicity in mice. J Sci Food Agric 2014; 94(9): 1764-71.
[http://dx.doi.org/10.1002/jsfa.6489] [PMID: 24272968]
[77]
Ghaffarzadegan R, S A-C, et al. Effect of aloe vera gel, compared to 1% silver sulfadiazine cream on second-degree burn wound healing 2013. Available from: cmja.arakmu.ac.ir Accessed: Jun. 08, 2023. Available from: http://cmja.arakmu.ac.ir/browse.php?a_code=A-10-166-2&sid=1&slc_lang=en
[78]
Teplicki E, Ma Q, Castillo DE, et al. The effects of aloe vera on wound healing in cell proliferation, migration, and viability. Wounds 2018; 30(9): 263-8.
[PMID: 30256753]
[79]
Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A. The effect of aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iran J Med Sci 2019; 44(1): 1-9.
[PMID: 30666070]
[80]
Haghani F, Arabnezhad MR, Mohammadi S, Ghaffarian-Bahraman A. Aloe vera and streptozotocin-induced diabetes mellitus. Rev Bras Farmacogn 2022; 32(2): 174-87.
[http://dx.doi.org/10.1007/s43450-022-00231-3] [PMID: 35287334]
[81]
Deora N, Venkatraman K. Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies. J Ayurveda Integr Med 2022; 13(4): 100675.
[http://dx.doi.org/10.1016/j.jaim.2022.100675] [PMID: 36481618]
[82]
Ceravolo I, Mannino F, Irrera N, et al. Health potential of aloe vera against oxidative stress induced corneal damage: An “in vitro” study. Antioxidants 2021; 10(2): 318.
[http://dx.doi.org/10.3390/antiox10020318] [PMID: 33672553]
[83]
Alkhouli M, Laflouf M, Alhaddad M. Efficacy of aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: A randomized controlled clinical trial. Compr Child Adolesc Nurs 2021; 44(1): 49-62.
[http://dx.doi.org/10.1080/24694193.2020.1727065] [PMID: 32101488]
[84]
Manirakiza A, Irakoze L, Manirakiza S. Aloe and its effects on cancer: A narrative literature review. East Afr Health Res J 2021; 5(1): 1-16.
[http://dx.doi.org/10.24248/eahrj.v5i1.645] [PMID: 34308239]
[85]
Sun ZA, Zhang XH, Xue Y, et al. [Effects of recombinant human granulocyte macrophage colony stimulating factor gel on treatment of full-thickness frostbite wounds on foot and hand]. Z Honghua S No shang za Z Hi 2020; 36(2): 117-21.
[http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2020.02.007] [PMID: 32114729]
[86]
Rath M, Bhattacharya A, Rath K, Santra S, Ghosh G, Nanda BB. A comprehensive study of the neuropharmacological profile of methanol leaf extract of aloe vera and identification of associated neuroprotective compounds through gas chromatography-mass spectrometry analysis. Indian J Pharm Sci 2020; 82(6)
[http://dx.doi.org/10.36468/pharmaceutical-sciences.731]
[87]
Shahryari M, Bibak B, Khaksari M, et al. Anti-edema effect of Aloe vera leaf extract following traumatic brain injury: Role of pro-inflammatory cytokines. Avicenna J Phytomed 2021; 11(4): 380-93.
[http://dx.doi.org/10.22038/AJP.2021.17426] [PMID: 34290969]
[88]
Tabatabaei SRF, Ghaderi S, Bahrami-Tapehebur M, Farbood Y, Rashno M. Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats. Biomed Pharmacother 2017; 96: 279-90.
[http://dx.doi.org/10.1016/j.biopha.2017.09.146] [PMID: 28988013]
[89]
López Z, Femenia A, Núñez-Jinez G, et al. In vitro immunomodulatory effect of food supplement from aloe vera. Evid Based Complement Alternat Med 2019; 2019: 1-9.
[http://dx.doi.org/10.1155/2019/5961742] [PMID: 30941196]
[90]
Guo X, Mei N. Aloe vera: A review of toxicity and adverse clinical effects. J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev 2016; 34(2): 77-96.
[http://dx.doi.org/10.1080/10590501.2016.1166826] [PMID: 26986231]
[91]
Chubak J, Boudreau DM, Rulyak SJ, Mandelson MT. Colorectal cancer risk in relation to use of acid suppressive medications. Pharmacoepidemiol Drug Saf 2009; 18(7): 540-4.
[http://dx.doi.org/10.1002/pds.1749] [PMID: 19367565]
[92]
Jangra A, Sharma G, Sihag S, Chhokar V. The dark side of miracle plant-Aloe vera: A review. Mol Biol Rep 2022; 49(6): 5029-40.
[http://dx.doi.org/10.1007/s11033-022-07176-9] [PMID: 35092563]
[93]
Ricciuti B, Leone MC, Metro G. Melanosis coli or ischaemic colitis? That is the question. BMJ Case Rep 2015; 2015: bcr2015212404.
[http://dx.doi.org/10.1136/bcr-2015-212404] [PMID: 26341164]
[94]
Teka T, Wang L, Gao J, et al. Polygonum multiflorum: Recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms. J Ethnopharmacol 2021; 271: 113864.
[http://dx.doi.org/10.1016/j.jep.2021.113864] [PMID: 33485980]
[95]
Morrow DM, Rapaport MJ, Strick RA. Hypersensitivity to Aloe. Arch Dermatol 1980; 116(9): 1064-5.
[http://dx.doi.org/10.1001/archderm.1980.01640330102026] [PMID: 7416761]
[96]
Tong X, Li M, Li D, et al. Aloe vera gel extract: Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells. J Ethnopharmacol 2021; 280: 114434.
[http://dx.doi.org/10.1016/j.jep.2021.114434] [PMID: 34274443]
[97]
Tungkasamit T, Chakrabandhu S, Samakgarn V, et al. Reduction in severity of radiation-induced dermatitis in head and neck cancer patients treated with topical aloe vera gel: A randomized multicenter double-blind placebo-controlled trial. Eur J Oncol Nurs 2022; 59: 102164.
[http://dx.doi.org/10.1016/j.ejon.2022.102164] [PMID: 35767935]
[98]
Heggie S, Bryant GP, Tripcony L, et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs 2002; 25(6): 442-51.
[http://dx.doi.org/10.1097/00002820-200212000-00007] [PMID: 12464836]
[99]
Lee A, Chui PT, Aun CST, Gin T, Lau ASC. Possible interaction between sevoflurane and Aloe vera. Ann Pharmacother 2004; 38(10): 1651-4.
[http://dx.doi.org/10.1345/aph.1E098] [PMID: 15292490]
[100]
Wacker J, Lucchinetti E, Jamnicki M, et al. Delayed inhibition of agonist-induced granulocyte-platelet aggregation after low-dose sevoflurane inhalation in humans. Anesth Analg 2008; 106(6): 1749-58.
[http://dx.doi.org/10.1213/ane.0b013e318172f9e9] [PMID: 18499605]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy