Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential

Title:Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential

Volume: 22 Issue: 12

Author(s): Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Marialaura Ontario, Gaetano Cammilleri, Licia Pantano, Maria Scuto, Mario Tomasello, Sestina Spanò, Angela Trovato Salinaro, Ali S. Abdelhameed, Vincenzo Ferrantelli, Antonio Arcidiacono, Tilman Fritsch, Gabriella Lupo*, Anna Signorile*, Luigi Maiolino, Salvatore Cuzzocrea and Vittorio Calabrese

Affiliation:

• Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy

• Department of Translational Biomedicine and Neuroscience, University of Bari, Aldo Moro, 70124, Bari, Italy

Abstract:

Background: Meniere's disease (MD) is a cochlear neurodegenerative disease. Hearing loss appears to be triggered by oxidative stress in the ganglion neurons of the inner ear.

Objective: Here, we confirm the variation of markers of oxidative stress and inflammation in patients with Meniere and hypothesize that chronic treatment with Coriolus mushroom helps in the response to oxidative stress and acts on α-synuclein and on NF-kB-mediated inflammatory processes

Methods: Markers of oxidative stress and inflammation were evaluated in MD patients with or without Coriolus treatment for 3 or 6 months.

Results: MD patients had a small increase in Nrf2, HO-1, γ-GC, Hsp70, Trx and sirtuin-1, which were further increased by Coriolus treatment, especially after 6 months. Increased markers of oxidative damage, such as protein carbonyls, HNE, and ultraweak chemiluminescence, associated with a decrease in plasma GSH/GSSG ratio, were also observed in lymphocytes from MD patients. These parameters were restored to values similar to the baseline in patients treated with Coriolus for both 3 and 6 months. Furthermore, treated MD subjects showed decreased expression of α-synuclein, GFAP and Iba-1 proteins and modulation of the NF-kB pathway, which were impaired in MD patients. These changes were greatest in subjects taking supplements for 6 months.

Conclusion: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on a-synuclein expression and on inflammatory processes NF-kB-mediated.

Cite this article as:

Paola Di Rosanna, Siracusa Rosalba, Fusco Roberta, Ontario Marialaura, Cammilleri Gaetano, Pantano Licia, Scuto Maria, Tomasello Mario, Spanò Sestina, Salinaro Trovato Angela, Abdelhameed S. Ali, Ferrantelli Vincenzo, Arcidiacono Antonio, Fritsch Tilman, Lupo Gabriella*, Signorile Anna*, Maiolino Luigi, Cuzzocrea Salvatore and Calabrese Vittorio, Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential, Current Neuropharmacology 2024; 22 (12) . https://dx.doi.org/10.2174/1570159X22666231206153936