Login Register Cart 0
Generic placeholder image

Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

An Overview of Chemistry and Bioactivity of Non-diterpenoid Alkaloids in the Genera Aconitum and Delphinium (Ranunculaceae)

Author(s): Tianpeng Yin* and Hongjun Jiang

Volume 27, Issue 21, 2023

Published on: 06 December, 2023

Page: [1857 - 1872] Pages: 16

DOI: 10.2174/0113852728277472231122092333

Price: $65

Abstract

Tribe Delphineae in the family Ranunculaceae is composed of the genera Aconitum and Delphinium and is a resource plant group with important medicinal value. Alkaloids are the main active ingredients in these two genera, with previous studies primarily focusing on diterpenoid alkaloids. Recent comprehensive studies of the chemical components have uncovered numerous non-diterpenoid alkaloids of diverse structural types, such as amides, isoquinolines, pyridines, phenethylamines, and diazines. These compounds exhibit various biological activities, including cardiotonic, antitumor, and antibacterial effects. In this paper, the structural characteristics and biological activities of 156 non-diterpenoid alkaloids reported in Aconitum and Delphinium are reviewed for the first time to provide references for the efficient utilization of plant resources of these two genera.

« Previous Next »
Graphical Abstract

[1]
de la Peña, S.; López, F.S.; Waizel-Bucay, J.; Monroy, C.P.; Sothern, R.B.; Lujambio, I.M.; Sánchez, C.O.; Betancourt, E. Circadian aspects of hyperthermia in mice induced by Aconitum napellus. Pharmacogn. Mag., 2011, 7(27), 234-242.
[http://dx.doi.org/10.4103/0973-1296.84238] [PMID: 21969795]
[2]
Ahmad, S.; Rehman, T.; Abbasi, W.M. Effects of homoeopathic ultrahigh dilutions of Aconitum napellus on Baker’s yeast-induced fever in rabbits. J. Integr. Med., 2017, 15(3), 209-213.
[http://dx.doi.org/10.1016/S2095-4964(17)60329-7] [PMID: 28494851]
[3]
Tai, C.J.; El-Shazly, M.; Wu, T.Y.; Lee, K.T.; Csupor, D.; Hohmann, J.; Chang, F.R.; Wu, Y.C. Clinical aspects of Aconitum preparations. Planta Med., 2015, 81(12-13), 1017-1028.
[PMID: 26166138]
[4]
Xiao, P.G.; Wang, F.P.; Gao, F.; Yan, L.P.; Chen, D.L.; Liu, Y. A pharmacophylogenetic study of Aconitum L. (Ranunculaceae) from China. Zhiwu Fenlei Xuebao, 2006, 44(1), 1-46.
[http://dx.doi.org/10.1360/aps050046]
[5]
Commission, C.P. Chinese Pharmacopoeia; China Medical Science and Technology Press: Beijing, 2020.
[6]
Zhou, G.; Tang, L.; Zhou, X.; Wang, T.; Kou, Z.; Wang, Z. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux. J. Ethnopharmacol., 2015, 160, 173-193.
[http://dx.doi.org/10.1016/j.jep.2014.11.043] [PMID: 25479152]
[7]
Yan, Y.; Jiang, H.; Yang, X.; Ding, Z.; Yin, T.; Grandiflolines, A-F. Grandiflolines A–F, new anti-inflammatory diterpenoid alkaloids isolated from Delphinium grandiflorum. Front Chem., 2022, 10, 1012874.
[http://dx.doi.org/10.3389/fchem.2022.1012874] [PMID: 36199660]
[8]
Wang, W.T. A revision of the genus Delphinium (Ranunculaceae) of China (I). Guangxi Zhi Wu, 2019, 39(11), 1425-1469.
[9]
Liu, X.Y.; Ke, B.W.; Qin, Y.; Wang, F.P. The diterpenoid alkaloids. Alkaloids Chem. Biol., 2022, 87, 1-360.
[http://dx.doi.org/10.1016/bs.alkal.2021.08.001] [PMID: 35168778]
[10]
Mi, L.; Li, Y.C.; Sun, M.R.; Zhang, P.L.; Li, Y.; Yang, H. A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids. Chin. J. Nat. Med., 2021, 19(7), 505-520.
[http://dx.doi.org/10.1016/S1875-5364(21)60050-X] [PMID: 34247774]
[11]
Tang, P.; Chen, Q.H.; Wang, F.P. Atropurpuran, a novel diterpene with an unprecedented pentacyclic cage skeleton, from Aconitum hemsleyanum var. atropurpureum. Tetrahedron Lett., 2009, 50(4), 460-462.
[http://dx.doi.org/10.1016/j.tetlet.2008.11.028]
[12]
Marín, C.; Díaz, J.G.; Irure Maiques, D.; Ramírez-Macías, I.; Rosales, M.J.; Guitierrez-Sánchez, R.; Cañas, R.; Sánchez-Moreno, M. Antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium gracile, D. staphisagria, Consolida oliveriana and from Aconitum napellus subsp. Lusitanicum. Phytochem. Lett., 2017, 19, 196-209.
[http://dx.doi.org/10.1016/j.phytol.2016.12.010]
[13]
Li, Y.R.; Liu, T.; Yan, R.Y.; Hui, L.Q.; Lin, L.; Cao, C.Y.; Guo, S.; Yang, L.X.; Feng, W.H.; Li, C.; Wang, Z.M. Three new phenolic glycosides from the whole plant of Aconitum tanguticum (Maxim.). Stapf. Phytochem. Lett., 2015, 11, 311-315.
[http://dx.doi.org/10.1016/j.phytol.2015.01.020]
[14]
Shen, Y.; Liang, W.J.; Shi, Y.N.; Kennelly, E.J.; Zhao, D.K. Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids. Nat. Prod. Rep., 2020, 37(6), 763-796.
[http://dx.doi.org/10.1039/D0NP00002G] [PMID: 32129397]
[15]
Qasem, A.M.A.; Zeng, Z.; Rowan, M.G.; Blagbrough, I.S. Norditerpenoid alkaloids from Aconitum and Delphinium: Structural relevance in medicine, toxicology, and metabolism. Nat. Prod. Rep., 2022, 39(3), 460-473.
[http://dx.doi.org/10.1039/D1NP00029B] [PMID: 34636385]
[16]
Yin, T.; Yan, Y.; Yang, X.; Li, W. Flavonoids from tribe Delphineae (Ranunculaceae): Phytochemical review and chemotaxonomic value. Biochem. Syst. Ecol., 2021, 97, 104300.
[http://dx.doi.org/10.1016/j.bse.2021.104300]
[17]
Yin, T.; Zhou, H.; Cai, L.; Ding, Z. Non-alkaloidal constituents from the genus Aconitum: A review. RSC Advances, 2019, 9(18), 10184-10194.
[http://dx.doi.org/10.1039/C9RA01219B] [PMID: 35520886]
[18]
Wan, L.X.; Zhang, J.F.; Zhen, Y.Q.; Zhang, L.; Li, X.; Gao, F.; Zhou, X.L. Isolation, structure elucidation, semi-synthesis, and structural modification of C19-diterpenoid alkaloids from Aconitum apetalum and their neuroprotective activities. J. Nat. Prod., 2021, 84(4), 1067-1077.
[http://dx.doi.org/10.1021/acs.jnatprod.0c01111] [PMID: 33666437]
[19]
Fan, Q.J.; Zhou, G.Z.; Xi, C.C.; Niu, B.; Cao, Y.G.; Zhang, F.; Naman, C.B.; Zhang, C.L.; Cao, Z.Y. Polysubstituted cyclopentene benzamides and dianthramide alkaloids from Delphinium anthriscifolium Hance. J. Nat. Prod., 2022, 85(4), 1157-1166.
[http://dx.doi.org/10.1021/acs.jnatprod.2c00107] [PMID: 35385291]
[20]
Hu, Z.X.; Zhao, L.H.; Tang, H.Y.; Aisa, H.A.; Zhang, Y.; Hao, X.J. Seven new anthranilamide derivatives from Aconitum apetalum. Fitoterapia, 2018, 128, 73-78.
[http://dx.doi.org/10.1016/j.fitote.2018.05.008] [PMID: 29772296]
[21]
Ablajan, N.; Zhao, B.; Wenjuan, X.; Zhao, J.; Sagdullaev, S.S.; Guoan, Z.; Aisa, H.A. Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities. Nat. Prod. Res., 2023, 37(8), 1382-1385.
[http://dx.doi.org/10.1080/14786419.2021.2005050] [PMID: 34802347]
[22]
Zhou, Y.L.; Zhang, D.N.; Qiao, J.X.; Wu, J.; Yan, Y.M.; Cao, Z.X.; Peng, C.; Tan, Y.Z. Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1/ROCK1/P-STAT3 pathways. Phytochemistry, 2023, 207, 113558.
[http://dx.doi.org/10.1016/j.phytochem.2022.113558] [PMID: 36521584]
[23]
Zou, Y.S.; Dawa, Z.; Lin, C.Z.; Zhang, Q.Y.; Yao, Y.F.; Yuan, Y.; Zhu, C.C.; Wang, Z.Y. New amide alkaloids from Delphinium brunonianum. Fitoterapia, 2019, 136, 104186.
[http://dx.doi.org/10.1016/j.fitote.2019.104186] [PMID: 31150769]
[24]
Chen, S.Y.; Liu, Y.Q.; Yang, C.R. Chemical constituents of Aconitum sinomontanum Nakai. Yunnan Zhi Wu Yan Jiu, 1980, 2(4), 473-475.
[25]
Shim, S.H.; Kim, J.S.; Son, K.H.; Bae, K.H.; Kang, S.S. Alkaloids from the roots of Aconitum pseudolaeve var. erectum. J. Nat. Prod., 2006, 69(3), 400-402.
[http://dx.doi.org/10.1021/np058073p] [PMID: 16562844]
[26]
Huang, S.; Wang, J.Z.; Guo, Q.J.; Xiao, Y.; Feng, Y.M.; Chen, L.; Xie, J.; Zhou, X.L. Diterpenoid alkaloids from two species of Delphinium. J. Asian Nat. Prod. Res., 2023, 25(8), 718-730.
[PMID: 36331432]
[27]
Jiang, Z.B.; Meng, X.H.; Jiang, B.Y.; Zhu, C.G.; Guo, Q.L.; Wang, S.J.; Lin, S.; Shi, J.G. Two 2-(quinonylcarboxamino)benzoates from the lateral roots of Aconitum carmichaelii. Chin. Chem. Lett., 2015, 26(6), 653-656.
[http://dx.doi.org/10.1016/j.cclet.2015.04.011]
[28]
Sun, L.M.; Huang, H.L.; Li, W.H.; Nan, Z.D.; Zhao, G.X.; Yuan, C.S. Alkaloids from Aconitum barbatum var. puberulum. Helv. Chim. Acta, 2009, 92(6), 1126-1133.
[http://dx.doi.org/10.1002/hlca.200800425]
[29]
Gong, C.; Zhou, G.; Jing, D.; Song, H.; Xu, J.; Meng, D. Three new compounds from Delphinium kamaonense Hunth and their in vitro cytotoxic and potential antioxidant activities. Chem. Biodivers., 2022, 19(7), e202200463.
[http://dx.doi.org/10.1002/cbdv.202200463] [PMID: 35785443]
[30]
Ahmad, H.; Ahmad, S.; Shah, S.A.A.; Khan, H.U.; Khan, F.A.; Ali, M.; Latif, A.; Shaheen, F.; Ahmad, M. Selective dual cholinesterase inhibitors from Aconitum laeve. J. Asian Nat. Prod. Res., 2018, 20(2), 172-181.
[http://dx.doi.org/10.1080/10286020.2017.1319820] [PMID: 28463565]
[31]
He, C.J.; Peng, C.; Xie, X.F.; Guo, L.; Zhou, Q.M.; Li, X.H.; Dai, O.; Geng, Z.; Guo, Y.P. Two new dianthramide glucosides with cardiomyocytes protective activity from Aconitum carmichaelii. Phytochem. Lett., 2013, 6(2), 299-301.
[http://dx.doi.org/10.1016/j.phytol.2013.03.008]
[32]
Wang, Y.; Sun, D.; Chen, Y.; Xu, J.; Xu, Y.; Yue, X.; Jia, J.; Li, H.; Chen, L. Alkaloids of Delphinium grandiflorum and their implication to H2O2-induced cardiomyocytes injury. Bioorg. Med. Chem., 2021, 37, 116113.
[http://dx.doi.org/10.1016/j.bmc.2021.116113] [PMID: 33744825]
[33]
Díaz, J.G.; Marapara, J.L.; Valdés, F.; Sazatornil, J.G.; Herz, W. Dianthramide glucosides from tissue cell cultures of Delphinium staphisagria L. Phytochemistry, 2005, 66(6), 733-739.
[http://dx.doi.org/10.1016/j.phytochem.2004.10.021] [PMID: 15771899]
[34]
Zhang, J.; Sun, G.B.; Lei, Q.F.; Li, G.Z.; Wang, J.C.; Si, J.Y. Chemical constituents of lateral roots of Aconitum carmichaelii Debx. Yao Xue Xue Bao, 2014, 49(8), 1150-1154.
[PMID: 25322557]
[35]
Yin, T.P.; Cai, L.; Li, Y.; Fang, Y.S.; Peng, L.; Ding, Z.T. New alkaloids from Aconitum stapfianum. Nat. Prod. Bioprospect., 2015, 5(6), 271-275.
[http://dx.doi.org/10.1007/s13659-015-0075-1] [PMID: 26458925]
[36]
Lin, M.; Zhang, Z.; Cai, S.; Jiang, H.; Yin, T. Brevicalamide, a new anthranilamide from Aconitum brevicalcaratum, suggests a new type of chemotaxonomic marker for tribe Delphineae. Biochem. Syst. Ecol., 2023, 109, 104671.
[http://dx.doi.org/10.1016/j.bse.2023.104671]
[37]
Huang, S.Z.; Cao, J.X.; Jiang, S.P.; Zhu, H.J. Alkaloids of the tibetan medicinal plant Aconitum naviculare stapf. Nat. Prod. Res. Dev., 2011, 23, 655-657.
[38]
Lee, T.H.; Chen, Y.C.; Lee, C.K.; Chang, H.S.; Kuo, C.C.; Chao, C.Y.; Lin, J-J.; Lo, L-C.; Kuo, Y-H. Aconitamide, A novel alkaloid from the roots of Aconitum carmichaeli. Nat. Prod. Commun.,, 2013, 8(6), 1934578X1300800.
[http://dx.doi.org/10.1177/1934578X1300800637]
[39]
Lee, S.Y.; Shim, S.H.; Kim, J.S.; Lee, J.H.; Lee, H.Y.; Jung, D.Y.; Ha, H.; Kim, C.; Kang, S.S. Norditerpenoid and dianthramide glucoside alkaloids from cultivated Aconitum species from Korea. Arch. Pharm. Res., 2007, 30(6), 691-694.
[http://dx.doi.org/10.1007/BF02977629] [PMID: 17679545]
[40]
Kosuge, T.; Yokota, M. Studies on the cardiac principle of aconite root. Chem. Pharm. Bull. (Tokyo), 1976, 24(1), 176-178.
[http://dx.doi.org/10.1248/cpb.24.176]
[41]
Li, J.; Chang, H.; Zhao, W.; Pi, H.; Ruan, H.; Zhang, P. New alkaloids from Aconitum vaginatum. Helv. Chim. Acta, 2014, 97(5), 689-693.
[http://dx.doi.org/10.1002/hlca.201300258]
[42]
Song, Z.; Gao, C.; Jiang, Q.; Xu, J.; Xiong, L.; Liu, K.; Sun, D.; Li, H.; Chen, L. Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity. Phytochemistry, 2021, 192, 112971.
[http://dx.doi.org/10.1016/j.phytochem.2021.112971] [PMID: 34628107]
[43]
Yin, T.; Yan, Y.; Jiang, H.; Yang, X. Alkaloids from Aconitum brachypodum and their network-based analysis of chemotaxonomic value. Biochem. Syst. Ecol., 2022, 105, 104534.
[http://dx.doi.org/10.1016/j.bse.2022.104534]
[44]
Yao, L.; Yan, Y.; Shu, Y.; Yang, Y.; Ce, G.; Wang, J.; Yin, T.; Cai, L. Chemical constituents with chemotaxonomic value from Aconitum georgei Comber. Biochem. Syst. Ecol., 2022, 104, 104474.
[http://dx.doi.org/10.1016/j.bse.2022.104474]
[45]
Kim, D.G.; Gwak, J.H.; Gwon, H.C.; Song, G.W.; Ji, O.P.; Lee, G.N. New aromatic amides from Aconitum pseudolaeve var. erectum. Yakhak Hoeji, 1996, 40(4), 418-421.
[46]
Dong, Y.; Wang, R.; Chen, Y. Studies on the chemical constituents of Delphinium iliense Huth. Chem. Res. Chin. Univ., 1992, (12), 1490-1492.
[47]
Ablajan, N.; Zhao, B.; Zhao, J.Y.; Kodirova, D.R.; Sagdullaev, S.S.; Aisa, H.A. Alkaloids from Delphinium aemulans. Chem. Nat. Compd., 2020, 56(5), 977-980.
[http://dx.doi.org/10.1007/s10600-020-03207-8]
[48]
Shaheen, F.; Ahmad, M.; Khan, M.T.H.; Jalil, S.; Ejaz, A.; Sultankhodjaev, M.N.; Arfan, M.; Choudhary, M.I. Atta-ur-Rahman, Alkaloids of Aconitum laeve and their anti-inflammatory, antioxidant and tyrosinase inhibition activities. Phytochemistry, 2005, 66(8), 935-940.
[http://dx.doi.org/10.1016/j.phytochem.2005.02.010] [PMID: 15934134]
[49]
Zou, Y.S.; Zeren, D.W.; Lin, C.Z.; Yao, Y.F.; Yuan, Y.; Zhu, C.C. Chemical constituents of Delphinium brunonianum. Zhong Yao Cai, 2019, 42(8), 1806-1809.
[50]
Nan, Z.D.; Li, X.A.; Chen, Y.X.; Ren, H.Z.; Xu, J.; Zhou, L.J. Chemical constituents from the Delphinium grandiflorum Herbs. Zhong Yao Cai, 2017, 40(9), 2077-2080.
[51]
Yang, L.; Zhang, Y.B.; Zhuang, L.; Li, T.; Chen, N.H.; Wu, Z.N.; Li, P.; Li, Y.L.; Wang, G.C. Diterpenoid alkaloids from Delphinium ajacis and their anti-RSV activities. Planta Med.,, 2017, 83((1-02)), 111-117.
[52]
Song, B.; Wang, F.Z.; Song, B. L.Y.; Zhang, H.W.; Huang, W.L.; Li, C.; Song, X.M.; Liu, J.L. Chemical constituents from Aconitum szechenyianum. Chin. Trad. Pat. Med., 2019, 41(8), 1871-1875.
[53]
Yang, L.H.; Li, C.; Lin, L.M.; Wang, Z.M.; Li, Z. Fat-soluble alkaloids from Aconitum tanguticum. Chin. J. Exp. Tradit. Med. Form., 2016, 22(10), 32-36.
[54]
Pan, Y.; Sun, C.; Chen, Y. A novel lactam from Delphinium caeruleum. J. Zhejiang Univ. Sci., 2000, 1(2), 186-187.
[http://dx.doi.org/10.1631/jzus.2000.0186]
[55]
Yang, L.H. L., C.; Lin, L.M.; Wang, Z.M.; Li, Z. Chemical constituents from whole plants of Aconitum tanguticum (IV). Chin. J. Exp. Tradit. Med. Form., 2016, 22(4), 39-44.
[56]
Han, Y.L.; Gao, L.M. hu, K.L.; Wei, T.B. Studies on the alkaliods from Delphinium grandiflorum. Chin. Tradit. Herbal Drugs, 2007, 38(2), 182-183.
[57]
Shim, S.H.; Lee, S.Y.; Kim, J.S.; Son, K.H.; Kang, S.S. Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli. Arch. Pharm. Res., 2005, 28(11), 1239-1243.
[http://dx.doi.org/10.1007/BF02978206] [PMID: 16350849]
[58]
Singh, H.; Singh, D.; Lekhak, M.M. Ethnobotany, botany, phytochemistry and ethnopharmacology of the genus Thalictrum L. (Ranunculaceae): A review. J. Ethnopharmacol., 2023, 305, 115950.
[http://dx.doi.org/10.1016/j.jep.2022.115950] [PMID: 36470306]
[59]
Wang, J.; Wang, L.; Lou, G.H.; Zeng, H.R.; Hu, J.; Huang, Q.W.; Peng, W.; Yang, X.B. Coptidis Rhizoma: A comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Pharm. Biol., 2019, 57(1), 193-225.
[http://dx.doi.org/10.1080/13880209.2019.1577466] [PMID: 30963783]
[60]
Chen, D.H.; Liang, X.T. Studies on the constituents of lateral root of Aconitum carmichaeli Debx. (Fu-Zi). I. Isolation and structural determination of salsolinol. Yao Xue Xue Bao, 1982, 17(10), 792-794.
[PMID: 6132517]
[61]
Hu, Z.X.; Tang, H.Y.; Yan, X.H.; Zeng, Y.R.; Aisa, H.A.; Zhang, Y.; Hao, X.J. Five new alkaloids from Aconitum apetalum (Ranunculaceae). Phytochem. Lett., 2019, 29, 6-11.
[http://dx.doi.org/10.1016/j.phytol.2018.10.017]
[62]
Qin, X.; Yang, S.; Zhao, Y.; Gao, Y.; Ren, F.; Zhang, D.; Wang, F. A new aporphine alkaloid from Aconitum carmichaelii. Chem. Nat. Compd., 2017, 53(3), 501-503.
[http://dx.doi.org/10.1007/s10600-017-2031-2]
[63]
Chen, H.S.; Han, G.Y.; Liu, M.Z. Fuzitine: A new aporphine alkaloid from Fu Zi (Accnitum carmicheali debx). Chin. Chem. Lett., 1991, 2(10), 787.
[64]
Liu, J.; Lin, Q.; Zhou, Q.M.; Meng, C.W.; Xiong, L.; Wang, X.Y.; Miao, L.L.; Guo, L.; Peng, C. A novel phenylisoquinoline alkaloid with cardioprotective effect from Aconiti lateralis radix praeparata. Zhongguo Zhongyao Zazhi, 2022, 47(12), 3265-3269.
[PMID: 35851120]
[65]
Velcheva, M.; Dutschewska, H.; Danghaaghiin, S.; Samdanghiin, Z.; Yansanghiin, Z. Two new pavine alkaloids from Thalictrum simplex. Planta Med., 1993, 59(3), 262-263.
[http://dx.doi.org/10.1055/s-2006-959665] [PMID: 17235968]
[66]
Lin, Z.; Hi, Z.W.; Qu, X.D.; Lin, S.J. Advances and challenges in microbial production of benzylisoquinoline alkaloids. Synth. Biol. J., 2021, 2(5), 716-733.
[67]
Kosuge, T.; Yokota, M.; Nagasawa, M. Studies on cardiac principle in Aconite roots. I. Isolation and structural determination of higenamine (author’s transl). Yakugaku Zasshi, 1978, 98(10), 1370-1375.
[http://dx.doi.org/10.1248/yakushi1947.98.10_1370] [PMID: 34017]
[68]
Bai, G.; Yang, Y.; Shi, Q.; Liu, Z.; Zhang, Q.; Zhu, Y. Identification of higenamine in Radix Aconiti lateralis preparata as a beta2-adrenergic receptor agonist. Acta Pharmacol. Sin., 2008, 29(10), 1187-1194.
[http://dx.doi.org/10.1111/j.1745-7254.2008.00859.x] [PMID: 18817623]
[69]
Wang, B.Y.; Yu, G.R.; Zheng, D.S.; Huang, M.X.; Gu, P.H.; Chen, Y.L.; Shang, M.; Jin, Z.J. Effect of dl-demethylcoclaurine on cultured rat heart cells. Acta Pharmacol. Sin., 1982, 3(2), 112-117.
[70]
Kimura, I.; Islam, M.A.; Kimura, M. Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: the effects of cholera toxin, forskolin and pertussis toxin. Biol. Pharm. Bull., 1996, 19(8), 1032-1037.
[http://dx.doi.org/10.1248/bpb.19.1032] [PMID: 8874810]
[71]
Liu, X.; Wagner, H.N., Jr; Tao, S. Measurement of effects of the Chinese herbal medicine higenamine on left ventricular function using a cardiac probe. Eur. J. Nucl. Med., 1983, 8(6), 233-236.
[http://dx.doi.org/10.1007/BF00522511] [PMID: 6873101]
[72]
Zhang, N.; Lian, Z.; Peng, X.; Li, Z.; Zhu, H. Applications of Higenamine in pharmacology and medicine. J. Ethnopharmacol., 2017, 196, 242-252.
[http://dx.doi.org/10.1016/j.jep.2016.12.033] [PMID: 28007527]
[73]
Wen, J.; Li, M.; Zhang, W.; Wang, H.; Bai, Y.; Hao, J.; Liu, C.; Deng, K.; Zhao, Y. Role of higenamine in heart diseases: Amini-review. Front. Pharmacol., 2022, 12, 798495.
[http://dx.doi.org/10.3389/fphar.2021.798495] [PMID: 35082678]
[74]
Zhang, N.; Li, Z.; Zhu, H. Higenamine as a potential pharmacologic stress agent in the detection of coronary artery disease. Chin. Med. Sci. J., 2022, 37(3), 275-281.
[http://dx.doi.org/10.24920/003936] [PMID: 36321183]
[75]
Yin, T.P.; Cai, L.; Xing, Y.; Yu, J.; Li, X.J.; Mei, R.F.; Ding, Z.T. Alkaloids with antioxidant activities from Aconitum handelianum. J. Asian Nat. Prod. Res., 2016, 18(6), 603-610.
[http://dx.doi.org/10.1080/10286020.2015.1114473] [PMID: 26744060]
[76]
Zhang, S.; Zhao, G.L.; Lin, G.Q. Alkaloids from Delphinium fangshanense. Phytochemistry, 1999, 51(2), 333-336.
[http://dx.doi.org/10.1016/S0031-9422(98)00756-0]
[77]
Wang, J.; Meng, X.H.; Chai, T.; Yang, J.L.; Shi, Y.P. Diterpenoid alkaloids and one lignan from the roots of Aconitum pendulum Busch. Nat. Prod. Bioprospect., 2019, 9(6), 419-423.
[http://dx.doi.org/10.1007/s13659-019-00227-y] [PMID: 31728851]
[78]
Lin, C.Z.; Liu, Z.J.; Bairi, Z.D.; Zhu, C.C. A new diterpenoid alkaloid isolated from Delphinium caeruleum. Chin. J. Nat. Med., 2017, 15(1), 45-48.
[http://dx.doi.org/10.1016/S1875-5364(17)30007-9] [PMID: 28259252]
[79]
Díaz, J.G.; Ruiz, J.G.; Herz, W. Alkaloids from Delphinium pentagynum. Phytochemistry, 2004, 65(14), 2123-2127.
[http://dx.doi.org/10.1016/j.phytochem.2004.03.017] [PMID: 15279983]
[80]
Wang, H.Y.; Zuo, A.X.; Sun, Y.; Rao, G.X. Chemical constituents of Aconitum brachypodum from Dong-Chuan area. Zhongguo Zhongyao Zazhi, 2013, 38(24), 4324-4328.
[PMID: 24791539]
[81]
Li, H.Y.; Yan, B.C.; Wei, L.X.; Sun, H.D.; Puno, P.T.; Tangutidines, A-C. three amphoteric diterpene alkaloids from Aconitum tanguticum. Nat. Prod. Bioprospect., 2021, 11(4), 459-464.
[http://dx.doi.org/10.1007/s13659-021-00310-3] [PMID: 33978930]
[82]
Gabbasov, T.M.; Tsyrlina, E.M.; Yunusov, M.S.; Teslenko, V.V.; Salokhin, A.V.; Sabutskii, Y.E.; Gorovoi, P.G. Alkaloids from Aconitum neosachalinense. Chem. Nat. Compd., 2014, 50, 1156-1157.
[83]
Sultankhodzhaev, M.N.; Yunusov, M.S.; Yunusov, S.Y. Alkaloids of Aconitum saposhnikovii and A. karacolicum. Chem. Nat. Compd., 1982, 18(2), 249-250.
[http://dx.doi.org/10.1007/BF00577224]
[84]
Takayama, H.; Hitotsuyanagi, Y.; Yamaguchi, K.; Aimi, N.; Sakai, S. On the Alkaloidal Constituents of Aconitum sanyoense NAKAI var. tonense NAKAI. Chem. Pharm. Bulletin. , 1992, 40(11), 2927-2931.
[http://dx.doi.org/10.1248/cpb.40.2927]
[85]
Vaisov, Z.M.; Bessonova, I.A.; Tel’nov, V.A. Alkaloids of Aconitum firmum and A. tokii. Chem. Nat. Compd., 1993, 29(1), 71-72.
[http://dx.doi.org/10.1007/BF00631022]
[86]
Vaisov, Z.M.; Yunusov, M.S. 14-Methylisotalatisidine — A new alkaloid from Delphinium confusum. Chem. Nat. Compd., 1987, 23(6), 725-727.
[http://dx.doi.org/10.1007/BF00596653]
[87]
Salimov, B.T.; Abdullaev, N.D.; Yunusov, M.S.; Yunusov, S.Y. Alkaloids of Delphinium dictyocarpum. Chem. Nat. Compd., 1978, 14(2), 194-198.
[http://dx.doi.org/10.1007/BF01134628]
[88]
Akhunova, K.I.; Turgunov, K.K.; Bobakulov, K.M.; Tashkhodzhaev, B.; Kulonov, A.I.; Abdullaev, S.V. Alkaloids from Delphinium oreophilum and biological activity of 14-acetylbrowniine. Chem. Nat. Compd., 2023, 59(2), 339-345.
[http://dx.doi.org/10.1007/s10600-023-03989-7]
[89]
Xie, S.M.; Lin, C.Z.; Zhu, C.C.; Bairi, Z.; Kangsa, S. Study on chemical constituents of Delphinium trichophorum Franch. Z Red Med., 2011, 22(5), 546-548.
[90]
Luo, Q.P.; Yang, C.K.; Zhang, L.; Liu, J.; Sha, B.C.; Shen, Y. Chemical constituents from the aerial parts of Aconitum vilmorinianum. z Hong sincerely invites 2022, 41(1), 108-113.
[91]
Manukov, A.N.; Vaisov, Z.M.; Denisenko, O.N.; Chelombit’ko, V.A. Alkaloids of Aconitum orientale. Chem. Nat. Compd., 1991, 27(6), 763-764.
[http://dx.doi.org/10.1007/BF00629954]
[92]
Zhang, L.; Yang, C.K.; Luo, Q.P.; Liu, J.; Chen, Y.P.; Shen, Y. Non-diterpenoid alkaloids in aerial parts of Aconitum carmichaelii. Chin. Tradit. Herbal Drugs, 2020, 51(3), 588-593.
[93]
Chen, L.; Shan, L.H.; Gao, F.; Huang, S.; Zhou, X.L. Alkaloids from whole plant of Delphinium delavayi. Chin. Tradit. Herbal Drugs, 2018, 49(8), 1773-1778.
[94]
Li, X.; Ye, M.; Gao, F.; Zhou, X.; Chen, L.; Huang, S. A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw. Nat. Prod. Res., 2023, 37(1), 130-135.
[http://dx.doi.org/10.1080/14786419.2021.1948043] [PMID: 34241556]
[95]
Matveev, V.M.; Narzullaev, A.S.; Sabirov, S.S.; Yunusov, M.S. Dehydroeldelidine? A new alkaloid from Delphinium ternatum. Chem. Nat. Compd., 1985, 21(1), 133-134.
[http://dx.doi.org/10.1007/BF00574282]
[96]
Malla, B.A.; Rafiq, S.; Hadi, A.; Ali, A.; Kaloo, Z.A.; Wagay, N.A.; Dar, N.A. Downregulation of pro-inflammatory markers NF-κB1, RelA and COX-2 using Aconitum chasmanthum Stapf ex Holmes-in vitro and in-silico study. Ind. Crops Prod., 2023, 197, 116564.
[http://dx.doi.org/10.1016/j.indcrop.2023.116564]
[97]
Li, X.; Ran, B.; Wang, L.; Yan, Z.; Yan, H. Method for extracting norglaucine and glaucine from Mongolian medicine Aconitum kusnezoffii leaf., CN Patent 110437151A,, 2019.
[98]
Takayama, H.; Tokita, A.K.I.K.O.N.A.K.A.D.A.; Ito, M.; Sakai, S.; Kurosaki, F.; Okamoto, T. On the alkaloids of Aconitum yezoense Nakai. Yakugaku Zasshi, 1982, 102(3), 245-257.
[http://dx.doi.org/10.1248/yakushi1947.102.3_245]
[99]
Xu, J.B.; Li, Y.Z.; Huang, S.; Chen, L.; Luo, Y.Y.; Gao, F.; Zhou, X.L. Diterpenoid alkaloids from the whole herb of Delphinium grandiflorum L. Phytochemistry, 2021, 190, 112866.
[http://dx.doi.org/10.1016/j.phytochem.2021.112866] [PMID: 34271299]
[100]
Xiong, L.; Peng, C.; Xie, X.F.; Guo, L.; He, C.J.; Geng, Z.; Wan, F.; Dai, O.; Zhou, Q.M. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules, 2012, 17(8), 9939-9946.
[http://dx.doi.org/10.3390/molecules17089939] [PMID: 22907155]
[101]
Li, X.H.; He, C.J.; Zhou, Q.M.; Liu, J.; Guo, L.; Peng, C. Chemical constituents from lateral roots of Aconitum carmichaelii. Chin. J. Exp. Tradit. Med. Form., 2013, 19, 86-89.
[102]
Wang, X.F.; Yu, L.; Hao, W.J.; Ma, L.; Yin, L.; Fu, X.Y. Chemical constituents of Aconitum flavum. Chem. Nat. Compd., 2016, 52(4), 769-770.
[http://dx.doi.org/10.1007/s10600-016-1771-8]
[103]
Yang, M.; Wan, L.; Chen, B.; Wang, M.K. Chemical constituents in chloroform fraction from parent roots of Aconitum carmichaeli. Drugs Clin., 2014, 29(3), 223-226.
[104]
Lin, C.; Qin, J.; Zhang, Y.; Ding, G. Diagnostically analyzing 1H NMR spectra of sub-types in chaetoglobosins for dereplication. RSC Advances, 2020, 10(4), 1946-1955.
[http://dx.doi.org/10.1039/C9RA10434H] [PMID: 35494616]
[105]
Kornsakulkarn, J.; Auncharoen, P.; Khonsanit, A.; Boonyuen, N.; Thongpanchang, C. Cytotoxic cytochalasans from cultures of the fungus Metarhizium brunneum TBRC-BCC 79240. RSC Advances, 2023, 13(16), 10564-10576.
[http://dx.doi.org/10.1039/D3RA00042G] [PMID: 37025662]
[106]
Yu, Y.; Wu, S.; Zhang, J.; Li, J.; Yao, C.; Wu, W.; Wang, Y.; Ji, H.; Wei, W.; Gao, M.; Li, Y.; Yao, S.; Huang, Y.; Bi, Q.; Qu, H.; Guo, D. Structurally diverse diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii Debx. and their anti-tumor activities based on in vitro systematic evaluation and network pharmacology analysis. RSC Advances, 2021, 11(43), 26594-26606.
[http://dx.doi.org/10.1039/D1RA04223H] [PMID: 35480028]
[107]
Michl, J.; Ingrouille, M.J.; Simmonds, M.S.J.; Heinrich, M. Naturally occurring aristolochic acid analogues and their toxicities. Nat. Prod. Rep., 2014, 31(5), 676-693.
[http://dx.doi.org/10.1039/c3np70114j] [PMID: 24691743]
[108]
Xu, Y.; Guo, Z.J.; Wu, N. Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum. Fitoterapia, 2010, 81(8), 1091-1093.
[http://dx.doi.org/10.1016/j.fitote.2010.07.005] [PMID: 20619325]
[109]
Guo, L.; Peng, C.; Dai, O.; Geng, Z.; Guo, Y.P.; Xie, X.F.; He, C.J.; Li, X.H. Two new pyrazines from the parent roots of Aconitum carmichaelii. Biochem. Syst. Ecol., 2013, 48, 92-95.
[http://dx.doi.org/10.1016/j.bse.2012.12.009]
[110]
Han, G.Y.; Liang, H.Q.; Zhang, W.D.; Chen, H.S.; Wang, J.Z.; Liao, Y.Z.; Liu, M.Z.; Shen, Q.H. Studies on the alkaloids and a new cardiac principle isolated from Jianyou Fuzi (Aconitum carmichaeli Debx.). Nat. Prod. Res. Dev., 1997, 9(3), 30-34.
[111]
Yang, Z.; Lu, Z.Q.; Zhang, Y.J.; Li, Y.B.; Wang, Z.Y.; Zhang, Y.L.; Zhuang, P.W.; Bai, G. Looking for agonists of β2 adrenergic receptor from Fuzi and Chuanwu by virtual screening and dual-luciferase reporter assay. J. Asian Nat. Prod. Res., 2016, 18(6), 550-561.
[http://dx.doi.org/10.1080/10286020.2015.1123692] [PMID: 26700061]
[112]
Xu, B.; Xue, J.; Tan, J.; Jiang, S.; Guo, F.; Li, Y. Two new alkaloids from the roots of Aconitum sinomontanum Nakai. Helv. Chim. Acta, 2014, 97(5), 727-732.
[http://dx.doi.org/10.1002/hlca.201300288]
[113]
Wang, X.; Li, Z.; Yang, B. -2,2Trans-2,2′,4,4′tetramethyl-6,6′-dinitroazo-benzene from Aconitum sungpanense. Fitoterapia, 2004, 75(7-8), 789-791.
[http://dx.doi.org/10.1016/j.fitote.2004.09.016] [PMID: 15567267]
[114]
Liu, J.; Yan, S.C.; Yang, C.K.; Zhang, L.; Luo, Q.P.; Shen, Y. Non-alkaloid constituents in the aerial parts of Aconitum transsectum. z Hong sincerely invites, 2020, 42(12), 3193-3193.
[115]
Faugeras, G. Presence of sympathomimetic amino phenols in aconites. Distribution of dopamine (3-hydroxytyramine), tyramine, and noradrenaline in Aconitum napellus and Aconitum paniculatum. Med. Plants Phytother., 1967, 1(2-3), 87-98.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy