Generic placeholder image

Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Editorial

Biological Potential and Therapeutic Effectiveness of Geiparvarin in Medicine for its Anti-proliferative Activity against Tumors and Other Human Complications

Author(s): Dinesh Kumar Patel*

Volume 24, Issue 16, 2023

Published on: 30 November, 2023

Page: [1221 - 1223] Pages: 3

DOI: 10.2174/0113894501271142231120065852

Price: $65

conference banner
Next »
[1]
Patel K, Kumar V, Verma A, Rahman M, Kumar Patel D. Health benefits of furanocoumarins ‘psoralidin’ an active phytochemical of psoralea corylifolia: the present, past and future scenario. Curr Bioact Compd 2019; 15(4): 369-76.
[http://dx.doi.org/10.2174/1573407214666180511153438]
[2]
Patel K, Patel DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report. J Tradit Complement Med 2017; 7(3): 360-6.
[http://dx.doi.org/10.1016/j.jtcme.2016.11.003] [PMID: 28725632]
[3]
Patel DK, Patel K. An overview of medicinal importance, pharmacological activities and analytical aspects of fraxin from cortex fraxinus. Curr Tradit Med 2023; 9(5): e190922208921.
[http://dx.doi.org/10.2174/2215083808666220919114652]
[4]
Patel DK, Patel K. Therapeutic effectiveness of sinensetin against cancer and other human complications: A review of biological potential and pharmacological activities. Cardiovasc Hematol Disord Drug Targets 2022; 22(3): 144-54.
[http://dx.doi.org/10.2174/1871529X23666221207121955] [PMID: 36503465]
[5]
Patel DK. Biological potential and therapeutic benefit of Chrysosplenetin: An Applications of polymethoxylated flavonoid in medicine from natural sources. Pharmacological Research -Modern Chinese Medicine. 2022; 4: 100155.
[http://dx.doi.org/10.1016/j.prmcm.2022.100155]
[6]
Patel DK, Patel K. Potential therapeutic applications of eudesmin in medicine: An overview on medicinal importance, pharmacological activities and analytical prospects. Pharmacological Research -Modern Chinese Medicine. 2022; 5: 100175.
[http://dx.doi.org/10.1016/j.prmcm.2022.100175]
[7]
Patel DK. Grandisin and its therapeutic potential and pharmacological activities: A review. Pharmacol Res -Modern Chinese Medicine. 2022; 5: 100176.
[8]
Chimichi S, Boccalini M, Cosimelli B, Dall’Acqua F, Viola G. New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity. Tetrahedron 2003; 59(28): 5215-23.
[http://dx.doi.org/10.1016/S0040-4020(03)00776-2]
[9]
Carotti A, Carrieri A, Chimichi S, et al. Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. Bioorg Med Chem Lett 2002; 12(24): 3551-5.
[http://dx.doi.org/10.1016/S0960-894X(02)00798-9] [PMID: 12443774]
[10]
Chimichi S, Boccalini M, Cosimelli B, Viola G, Vedaldi D, Dall’Acqua F. New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents. Tetrahedron Lett 2002; 43(42): 7473-6.
[http://dx.doi.org/10.1016/S0040-4039(02)01798-7]
[11]
Al-Soud YA, Al-Sa’doni HH, Amajaour HAS, Salih KSM, Mubarakb MS, Al-Masoudic NA. Synthesis, Characterization and anti-HIV and antitumor activities of new coumarin derivatives. Z Naturforsch B J Chem Sci 2008; 63(1): 83-9.
[http://dx.doi.org/10.1515/znb-2008-0112]
[12]
Bocca C, Gabriel L, Miglietta A. Cytoskeleton-interacting activity of geiparvarin, diethylstilbestrol and conjugates. Chem Biol Interact 2001; 137(3): 285-305.
[http://dx.doi.org/10.1016/S0009-2797(01)00261-7] [PMID: 11566295]
[13]
Chen S, Zou H, Wang B, Du J, Zhang Z, Huang P. Geiparvarin inhibits the progression of osteosarcoma by down-regulating COX2 expression. Curr Cancer Drug Targets 2023; 23(5): 379-87.
[http://dx.doi.org/10.2174/1568009623666221208113432] [PMID: 36503472]
[14]
Jiang F, Wang GJ, Huang P, et al. Geiparvarin Inhibits OS Metastasis through Upregulation of ANGPTL4 Expression by Inhibiting miR-NA-3912-3p Expression. Evid Based Complement Alternat Med 2022; 2022: 1-8.
[http://dx.doi.org/10.1155/2022/4663684] [PMID: 35463073]
[15]
Zhang Y, Lv Z, Zhong H, et al. Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. Eur J Med Chem 2012; 53: 356-63.
[http://dx.doi.org/10.1016/j.ejmech.2012.04.026] [PMID: 22579780]
[16]
Chimichi S, Boccalini M, Salvador A, Dall’Acqua F, Basso G, Viola G. Synthesis and biological evaluation of new geiparvarin derivatives. ChemMedChem 2009; 4(5): 769-79.
[http://dx.doi.org/10.1002/cmdc.200900009] [PMID: 19322800]
[17]
Viola G, Vedaldi D, dall’Acqua F et al. Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues. Chem Biodivers 2004; 1(9): 1265-80.
[http://dx.doi.org/10.1002/cbdv.200490089] [PMID: 17191904]
[18]
Miglietta A, Bocca C, Rampa A, Bisi A, Gabriel L. Geiparvarin and derivatives in combination with taxol: Effect on microtubular organization in 3T3 fibroblasts. Anticancer Drug Des 1997; 12(8): 607-20.
[PMID: 9448701]
[19]
Valenti P, Rampa A, Recanatini M, et al. Synthesis, cytotoxicity and SAR of simple geiparvarin analogues. Anticancer Drug Des 1997; 12(6): 443-51.
[PMID: 9311554]
[20]
Valenti P, Rampa A, Bisi A, et al. Some geiparvarin bioisosteres and homologues: Synthesis and biological evaluation against human colon carcinoma cells (LoVo). Anticancer Drug Des 1997; 12(2): 137-44.
[PMID: 9113068]
[21]
Miglietta A, Bocca C, Gadoni E, et al. Interaction of geiparvarin and related compounds with purified microtubular protein. Anticancer Drug Des 1996; 11(1): 35-48.
[PMID: 8639247]
[22]
Baraldi PG, Manfredini S, Simoni D, Tabrizi MA, Balzarini J, De Clercq E. Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. J Med Chem 1992; 35(10): 1877-82.
[http://dx.doi.org/10.1021/jm00088a025] [PMID: 1588564]
[23]
Simoni D, Manfredini S, Tabrizi MA, et al. Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. J Med Chem 1991; 34(11): 3172-6.
[http://dx.doi.org/10.1021/jm00115a004] [PMID: 1956034]
[24]
Baraldi PG, Guarneri M, Manfredini S, Simoni D, Balzarini J, De Clercq E. Synthesis and cytostatic activity of geiparvarin analogs. J Med Chem 1989; 32(2): 284-8.
[http://dx.doi.org/10.1021/jm00122a002] [PMID: 2913291]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy