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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Review Article

A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles

Author(s): Thoraya A. Farghaly*, Ghada S. Masaret, Sayed M. Riyadh and Marwa F. Harras

Volume 24, Issue 17, 2024

Published on: 24 November, 2023

Page: [1602 - 1629] Pages: 28

DOI: 10.2174/0113895575277122231108095511

Price: $65

Abstract

Out of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs or non-nucleosides. Many synthetic techniques have been produced by scientists around the world as a result of their wide-ranging biological function. In this review, we have tried to summarize new synthetic methods produced by diverse research groups as well as provide a comprehensive description of the function of [1,2,4] and [1,2,3]-triazole derivatives as antiviral agents. Antiviral triazole compounds have been shown to target a wide variety of molecular proteins. In addition, several strains of viruses, including the human immunodeficiency virus, SARS virus, hepatitis B and C viruses, influenza virus, Hantavirus, and herpes virus, were discovered to be susceptible to triazole derivatives. This review article covered the reports for antiviral activity of both 1,2,3- and 1,2,4-triazole moieties up to 2022.

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