Generic placeholder image

Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Review Article

A Review of Clinical Trials of Cancer and Its Treatment as a Vaccine

Author(s): Chandani Chandarana* and Anuradha Tiwari

Volume 19, Issue 1, 2024

Published on: 10 November, 2023

Page: [7 - 33] Pages: 27

DOI: 10.2174/0115748871260733231031081921

Price: $65

Abstract

Background: Cancer and infectious diseases are one of the greatest challenges of modern medicine. An unhealthy lifestyle, poor drug use, or drug misuse contribute to the rise in morbidity and mortality brought on by these illnesses. The inadequacies of the medications now being used to treat these disorders, along with the growing issue of drug resistance, have compelled researchers to look for novel compounds with therapeutic promise. The number of infections and diseases has significantly abated due to vaccine development and use over time, which is described in detail. Several novel vaccines can now be produced by manipulating Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA), Messenger Ribonucleic acid (mRNA), proteins, viral vector Recombinant, and other molecules due to advances in genetic engineering and our understanding of the immune defense.

Objective: The main topic of discussion is cancer-based vaccinations, which were developed less than a decade ago but have already been used to treat a wide range of both life-threatening and deadly diseases. It contains clinical studies for cancer vaccines against kidney, liver, prostate, cervix, and certain RNA-based cancer vaccines against breast and bladder cancer.

Results: Numerous studies using various DNA and RNA-based methods have been conducted on the basis of cancer, with 9-10 diseases related to DNA and 8–9 diseases associated with RNA. Some of these studies have been completed, while others have been eliminated due to a lack of research; further studies are ongoing regarding the same.

Conclusion: This brief discussion of vaccines and their varieties with examples also discusses vaccine clinical trials in relation to cancer diseases in this DNA and RNA-based cancer vaccine that has had successful clinical trials like the cervical cancer drug VGX-3100, the kidney cancer drug Pembrolizumab, MGN-1601, the prostate cancer drug pTVG-HP with rhGM-CSF, the melanoma cancer drug proteasome siRNA, and the lung cancer drug FRAME-001.

Graphical Abstract

[1]
Czochor J, Turchick A. Introduction. Vaccines. Yale J Biol Med 2014; 87(4): 401-2.
[PMID: 25647837]
[2]
Banchereau J, Palucka K. Cancer vaccines on the move. Nat Rev Clin Oncol 2018; 15(1): 9-10.
[http://dx.doi.org/10.1038/nrclinonc.2017.149] [PMID: 28895570]
[3]
Kallerup RS, Foged C. Classification of vaccines. In: Foged C, Rades T, Perrie Y, Hook S, Eds. Subunit Vaccine Delivery Advances in Delivery Science and Technology. In: Foged C, Rades T, Perrie Y, Hook S, Eds. New York, NY: Springer 2015; pp. 15-29.
[http://dx.doi.org/10.1007/978-1-4939-1417-3_2]
[4]
Depelsenaire AC, Kendall MA, Young PR, Muller DA. Introduction to vaccines and vaccination. In Micro and nanotechnology in vaccine development, Micro and Nano Technologies. William Andrew Publishing 2017; pp. 47-62.
[http://dx.doi.org/10.1016/B978-0-323-39981-4.00003-8]
[5]
Yang B, Jeang J, Yang A, Wu TC, Hung CF. DNA vaccine for cancer immunotherapy. Hum Vaccin Immunother 2014; 10(11): 3153-64.
[http://dx.doi.org/10.4161/21645515.2014.980686] [PMID: 25625927]
[6]
Moyle PM. Progress in vaccine development. Curr Protoc Microbiol 2015; 36(1): 11-26.
[http://dx.doi.org/10.1002/9780471729259.mc1801s36] [PMID: 25641099]
[7]
Wang B. Gene inoculation generates immune responses against human miinuni> dericiency virus type 1. Proc Natt Acad Sci 1993; 90: 4156-60.
[http://dx.doi.org/10.1073/pnas.90.9.4156] [PMID: 8483929]
[8]
Yadav DK, Yadav N, Khurana SM. Vaccines: Present status and applications. In: Animal Biotechnology: Models in Discovery and Translation. Academic Press 2014; pp. 491-508.
[http://dx.doi.org/10.1016/B978-0-12-416002-6.00026-2]
[9]
Pascolo S. Messenger RNA-based vaccines. Expert Opin Biol Ther 2004; 4(8): 1285-94.
[http://dx.doi.org/10.1517/14712598.4.8.1285] [PMID: 15268662]
[10]
Machado BAS, Hodel KVS, Fonseca LMS, et al. The importance of RNA-based vaccines in the fight against COVID-19: An overview. Vaccines 2021; 9(11): 1345.
[http://dx.doi.org/10.3390/vaccines9111345] [PMID: 34835276]
[11]
Silveira MM, Moreira GMSG, Mendonça M. DNA vaccines against COVID-19: Perspectives and challenges. Life Sci 2021; 267: 118919.
[http://dx.doi.org/10.1016/j.lfs.2020.118919] [PMID: 33352173]
[12]
Lundstrom K. RNA-based drugs and vaccines. Expert Rev Vaccines 2015; 14(2): 253-63.
[http://dx.doi.org/10.1586/14760584.2015.959932] [PMID: 25220891]
[13]
Wolff JA, Malone RW, Williams P, et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247(4949): 1465-8.
[http://dx.doi.org/10.1126/science.1690918] [PMID: 1690918]
[14]
Iavarone C, O’hagan DT, Yu D, Delahaye NF, Ulmer JB. Mechanism of action of mRNA-based vaccines. Expert Rev Vaccines 2017; 16(9): 871-81.
[http://dx.doi.org/10.1080/14760584.2017.1355245] [PMID: 28701102]
[15]
Pascolo S. Synthetic messenger RNA-based vaccines: From scorn to hype. Viruses 2021; 13(2): 270.
[http://dx.doi.org/10.3390/v13020270] [PMID: 33572452]
[16]
Rossen RD, Birdsall HH. Allergy and immunology. In: Medical Secrets. E-Book Elesvier Mosby 2011; pp. 291-343.
[http://dx.doi.org/10.1016/B978-0-323-06398-2.00012-6]
[17]
Plitnick LM. Global regulatory guidelines for vaccines. In: Nonclinical development of novel biologics biosimilars vaccines and specialty biologics. Academic Press 2013; pp. 225-41.
[http://dx.doi.org/10.1016/B978-0-12-394810-6.00009-5]
[18]
Gao Q, Bao L, Mao H, et al. Development of an inactivated vaccine candidate for SARS-CoV-2. Science 2020; 369(6499): 77-81.
[http://dx.doi.org/10.1126/science.abc1932] [PMID: 32376603]
[19]
Wood JM, Robertson JS. From lethal virus to life-saving vaccine: Developing inactivated vaccines for pandemic influenza. Nat Rev Microbiol 2004; 2(10): 842-7.
[http://dx.doi.org/10.1038/nrmicro979] [PMID: 15378048]
[20]
Abinaya RV, Viswanathan P. Biotechnology-based therapeutics. In Translational Biotechnology, A Journey from Laboratory to Clinics. Academic Press 2021; pp. 27-52.
[http://dx.doi.org/10.1016/B978-0-12-821972-0.00019-8]
[21]
Bröker M, Berti F, Schneider J, Vojtek I. Polysaccharide conjugate vaccine protein carriers as a “neglected valency” – Potential and limitations. Vaccine 2017; 35(25): 3286-94.
[http://dx.doi.org/10.1016/j.vaccine.2017.04.078] [PMID: 28487056]
[22]
Vartak A, Sucheck S. Recent advances in subunit vaccine carriers. Vaccines 2016; 4(2): 12.
[http://dx.doi.org/10.3390/vaccines4020012] [PMID: 27104575]
[23]
Haemophilus Influenzae Type b (Hib) VIS. Available from:https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hib.html(accessed Oct. 12, 2022)
[24]
Ura T, Okuda K, Shimada M. Developments in viral vector-based vaccines. Vaccines 2014; 2(3): 624-41.
[http://dx.doi.org/10.3390/vaccines2030624] [PMID: 26344749]
[25]
Bubeník J. Genetically engineered dendritic cell-based cancer vaccines (Review). Int J Oncol 2001; 18(3): 475-8.
[http://dx.doi.org/10.3892/ijo.18.3.475] [PMID: 11179474]
[26]
Geall AJ, Mandl CW, Ulmer JB. RNA: The new revolution in nucleic acid vaccines. Semin Immunol 2013; 25(2): 152-9.
[http://dx.doi.org/10.1016/j.smim.2013.05.001]
[27]
Fleeton MN, Chen M, Berglund P, et al. Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus. J Infect Dis 2001; 183(9): 1395-8.
[http://dx.doi.org/10.1086/319857] [PMID: 11294672]
[28]
Jones RGA, Liu Y, Rigsby P, Sesardic D. An improved method for development of toxoid vaccines and antitoxins. J Immunol Methods 2008; 337(1): 42-8.
[http://dx.doi.org/10.1016/j.jim.2008.05.009] [PMID: 18571196]
[29]
Strikas RA, Mawle AC, Pickering LK, Orenstein WA. Active immunization. In: Principles and Practice of Pediatric Infectious Diseases. Elsevier 2018; pp. 43-71.
[http://dx.doi.org/10.1016/B978-0-323-40181-4.00006-2]
[30]
Cheng K, Zhao R, Li Y, et al. Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology. Nat Commun 2021; 12(1): 2041.
[http://dx.doi.org/10.1038/s41467-021-22308-8] [PMID: 33824314]
[31]
Cheng K, Kang Q, Zhao X. Biogenic nanoparticles as immunomodulator for tumor treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2020; 12(6): e1646.
[http://dx.doi.org/10.1002/wnan.1646] [PMID: 32464709]
[32]
Bachmann MF, Jennings GT. Vaccine delivery: A matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol 2010; 10(11): 787-96.
[http://dx.doi.org/10.1038/nri2868] [PMID: 20948547]
[33]
Mayrand D, Grenier D. Biological activities of outer membrane vesicles. Can J Microbiol 1989; 35(6): 607-13.
[http://dx.doi.org/10.1139/m89-097] [PMID: 2670152]
[34]
Immunization - ClinicalKey Available from: https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323482554003167 (accessed Oct. 12, 2022)
[35]
Payton NM, Lodaya RN, Padilla AM. Lyophilized vaccine development. In: Practical Aspects of Vaccine Development. Academic Press 2022; pp. 297-327.
[http://dx.doi.org/10.1016/B978-0-12-814357-5.00002-7]
[36]
Klein JO, Sawabe E, Inase N, Yoshizawa Y. Nippon rinsho. Jpn J Clin Med 2009; 60(1): 302-14.
[http://dx.doi.org/10.1016/B978-1-4160-4044-6.50032-7]
[37]
Talwar GP. My journey with human chorionic gonadotropin: Development of a unique vaccine for control of fertility In: 100 Years of Human Chorionic Gonadotropin, Reviews and New Perspectives. Elsevier 2020; pp. 209-25.
[http://dx.doi.org/10.1016/B978-0-12-820050-6.00019-9]
[38]
Girard MP, Koff WC. Human immunodeficiency virus vaccines. In Plotkin’s Vaccines. Elsevier 2018; pp. 400-29.
[http://dx.doi.org/10.1016/B978-0-323-35761-6.00029-8]
[39]
Ulmer JB, Mason PW, Geall A, Mandl CW. RNA-based vaccines. Vaccine 2012; 30(30): 4414-8.
[http://dx.doi.org/10.1016/j.vaccine.2012.04.060] [PMID: 22546329]
[40]
Cui Z. DNA vaccine. Adv Genet 2005; 54: 257-89.
[http://dx.doi.org/10.1016/S0065-2660(05)54011-2] [PMID: 16096015]
[41]
Versteeg L, Almutairi MM, Hotez PJ, Pollet J. Enlisting the mRNA vaccine platform to combat parasitic infections. Vaccines 2019; 7(4): 122.
[http://dx.doi.org/10.3390/vaccines7040122] [PMID: 31547081]
[42]
Zhang C, Maruggi G, Shan H, Li J. Advances in mRNA vaccines for infectious diseases. Front Immunol 2019; 10: 594.
[http://dx.doi.org/10.3389/fimmu.2019.00594] [PMID: 30972078]
[43]
Weiner DB, Nabel GJ. Development of gene-based vectors for immunization. In: Plotkin’s Vaccines. Elsevier 2018.
[http://dx.doi.org/10.1016/B978-0-323-35761-6.00067-5]
[44]
Ertl HC. Next generation of rabies vaccines. In: Rabies, Scientific Basis of the Disease and its Management. Academic Press 2020; pp. 509-26.
[http://dx.doi.org/10.1016/B978-0-12-818705-0.00015-7]
[45]
Cid R, Bolívar J. Platforms for production of protein-based vaccines: From classical to next-generation strategies. Biomolecules 2021; 11(8): 1072.
[http://dx.doi.org/10.3390/biom11081072] [PMID: 34439738]
[46]
Srivastava IK, Liu MA, Liu MD. Gene vaccines. Ann Intern Med 2003; 138(7): 550-9.
[http://dx.doi.org/10.7326/0003-4819-138-7-200304010-00011] [PMID: 12667025]
[47]
Zahoor MA, Khurshid M, Qureshi R, Naz A, Shahid M. Cell culture-based viral vaccines: Current status and future prospects. Future Virol 2016; 11(7): 549-62.
[http://dx.doi.org/10.2217/fvl-2016-0006]
[48]
Broadbent AJ, Boonnak K, Subbarao K. Respiratory virus vaccines. In Mucosal Immunol. Elsevier Inc 2015; pp. 1129-70.
[http://dx.doi.org/10.1016/B978-0-12-415847-4.00059-8]
[49]
Putnak R, Porter K, Schmaljohn C. DNA vaccines for flaviviruses. In: Advances in Virus Research. Elsevier 2003; pp. 445-69.
[http://dx.doi.org/10.1016/S0065-3527(03)61012-2]
[50]
Sami D, Ennaji MM. Global epidemiology and genetic variability of rabies viruses. In: Emerging and Reemerging Viral Pathogens. Elsevier 2020.
[http://dx.doi.org/10.1016/B978-0-12-814966-9.00014-7]
[51]
Leitner WW, Ying H, Restifo NP. DNA and RNA-based vaccines: Principles, progress and prospects. Vaccine 1999; 18(9-10): 765-77.
[http://dx.doi.org/10.1016/S0264-410X(99)00271-6] [PMID: 10580187]
[52]
Valilou SF, Keshavarz-fathi M. Genetic vaccine for cancer. In: Vaccines for Cancer Immunotherapy, Nima Rezaei and Mahsa Keshavarz-Fathi. Elsevier 2019; pp. 129-43.
[http://dx.doi.org/10.1016/B978-0-12-814039-0.00010-2]
[53]
Norrby E. The pathogenesis of persistent infections. In: Textbook of Medical Virology. Butterworth-Heinemann 1983; pp. 144-54.
[http://dx.doi.org/10.1016/B978-0-407-00253-1.50021-9]
[54]
Gershon AA, Breuer J, Cohen JI, et al. Varicella zoster virus infection. Nat Rev Dis Primers 2015; 1(1): 15016.
[http://dx.doi.org/10.1038/nrdp.2015.16] [PMID: 27188665]
[55]
Pfaller S. Innovative methods for determining the microbiological quality of drinking water. In: Comprehensive Water Quality and Purification. Elsevier 2014; pp. 230-48.
[http://dx.doi.org/10.1016/B978-0-12-382182-9.00036-0]
[56]
Gerba CP. Environmentally transmitted pathogens. In: Environmental microbiology. Academic Press 2009; pp. 445-84.
[http://dx.doi.org/10.1016/B978-0-12-394626-3.00022-3]
[57]
Artenstein AW, Opal JM, Opal SM, Tramont EC, Peter G, Russell PK. History of U.S. military contributions to the study of vaccines against infectious diseases. Mil Med 2005; 170(4S): 3-11.
[http://dx.doi.org/10.7205/MILMED.170.4S.3] [PMID: 15916278]
[58]
Fougeroux C, Holst P. Future prospects for the development of cost-effective adenovirus vaccines. Int J Mol Sci 2017; 18(4): 686.
[http://dx.doi.org/10.3390/ijms18040686] [PMID: 28420073]
[59]
Cella D, Yount S, Brucker PS, et al. Development and validation of a scale to measure disease-related symptoms of kidney cancer. Value Health 2007; 10(4): 285-93.
[http://dx.doi.org/10.1111/j.1524-4733.2007.00183.x] [PMID: 17645683]
[60]
Sivarajah S, Emerick K, Kaufman HL. What surgeons need to know about gene therapy for cancer. Adv Surg 2022; 56(1): 151-68.
[http://dx.doi.org/10.1016/j.yasu.2022.02.006] [PMID: 36096566]
[61]
Park Y. Obesity and cancer: Epidemiological evidence. In: Encyclopedia of Cancer. Elsevier 2018; pp. 88-97.
[http://dx.doi.org/10.1016/B978-0-12-801238-3.65037-7]
[62]
Tagliamonte M, Petrizzo A, Mauriello A, Tornesello ML, Buonaguro FM, Buonaguro L. Potentiating cancer vaccine efficacy in liver cancer. OncoImmunology 2018; 7(10): e1488564.
[http://dx.doi.org/10.1080/2162402X.2018.1488564] [PMID: 30288355]
[63]
Vaccines That Can Help Prevent Cancer Available from: https://www.cdc.gov/cancer/dcpc/prevention/vaccination.htm (accessed Sep. 28, 2022)
[64]
Tangpukdee N, Duangdee C, Wilairatana P, Krudsood S. Malaria diagnosis: A brief review. Korean J Parasitol 2009; 47(2): 93-102.
[http://dx.doi.org/10.3347/kjp.2009.47.2.93] [PMID: 19488414]
[65]
Scholar E. Malaria Compreh Pharmacol Ref 2007; 1–5: 1-5.
[http://dx.doi.org/10.1016/B978-008055232-3.60932-8]
[66]
D’Souza J, Nderitu D. Ethical considerations for introducing RTS,S/AS01 in countries with moderate to high Plasmodium falciparum malaria transmission. Lancet Glob Health 2021; 9(12): e1642-3.
[http://dx.doi.org/10.1016/S2214-109X(21)00498-8] [PMID: 34798015]
[67]
Harrington KJ, Nutting CM. Radiation therapy for head and neck cancer kate newbold and shreerang a bhide. In: InPrinciples and Practice of Head and Neck Surgery and Oncology. CRC Press 2009.
[http://dx.doi.org/10.3109/9781439825464-9]
[68]
Das P, Deshmukh N, Badore N, Ghulaxe C, Patel P. A review article on melanoma. J pharm Sci Res 2016; 8(2): 112.
[69]
Federico SM, McCarville MB, Shulkin BL, et al. A pilot trial of humanized anti-GD2 monoclonal antibody (hu14.18K322A) with chemotherapy and natural killer cells in children with recurrent/refractory neuroblastoma. Clin Cancer Res 2017; 23(21): 6441-9.
[http://dx.doi.org/10.1158/1078-0432.CCR-17-0379] [PMID: 28939747]
[70]
Routine vaccination against chickenpox? Drug Ther Bull 2012; 50(4): 42-5.
[http://dx.doi.org/10.1136/dtb.2012.04.0098] [PMID: 22495050]
[71]
Yang S, Zhang W, Shen Q, et al. Aichi virus strains in children with gastroenteritis, China. Emerg Infect Dis 2009; 15(10): 1703-5.
[http://dx.doi.org/10.3201/eid1510.090522] [PMID: 19861087]
[72]
Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. Lancet 2019; 393(10167): 169-82.
[http://dx.doi.org/10.1016/S0140-6736(18)32470-X] [PMID: 30638582]
[73]
Kirby T. FDA approves new upgraded Gardasil 9. Lancet Oncol 2015; 16(2): e56.
[http://dx.doi.org/10.1016/S1470-2045(14)71191-X] [PMID: 25532625]
[74]
Pantuck J. Bladder cancer. In: Nutritional Oncology. ELsevier 2006.
[http://dx.doi.org/10.1016/B978-012088393-6/50082-8]
[75]
Efstathiou JA, Zietman AL. Bladder cancer. In: Clinical Radiation Oncology. Elsevier 2016; pp. 1096-1120.e6.
[http://dx.doi.org/10.1016/B978-0-323-24098-7.00054-X]
[76]
BCG vaccines: WHO position paper Available from: https://apps.who.int/iris/handle/10665/260307 (accessed Sep. 28, 2022)
[77]
Houghton BB, Chalasani V, Hayne D, et al. Intravesical chemotherapy plus bacille Calmette-Guérin in non-muscle invasive bladder cancer: A systematic review with meta-analysis. BJU Int 2013; 111(6): 977-83.
[http://dx.doi.org/10.1111/j.1464-410X.2012.11390.x] [PMID: 23253618]
[78]
Green J, Fuge O, Allchorne P, Vasdev N. Immunotherapy for bladder cancer. Res Rep Urol 2015; 7: 65-79.
[http://dx.doi.org/10.2147/RRU.S63447] [PMID: 26000263]
[79]
Gupta S. Viral hepatitis: Historical perspective, etiology, epidemiology, and pathophysiology. In: Studies on Hepatitis Viruses: Life Cycle, Structures, Functions, and Inhibition 0. Elsevier 2018; pp. 1-14.
[http://dx.doi.org/10.1016/B978-0-12-813330-9.00001-6]
[80]
Dotzauer A. Hepatitis A virus. In: Desk Encyclopedia of Human and Virology. Academic press, Elsevier 2008; p. 343.
[http://dx.doi.org/10.1016/B978-012374410-4.00412-X]
[81]
te Winkel B, Schaefer C. Infections during breastfeeding. In: Drugs During Pregnancy and Lactation Treatment Options and Risk Assessment. Academic Press 2015; pp. 821-33.
[http://dx.doi.org/10.1016/B978-0-12-408078-2.00040-8]
[82]
Theeten H, Van Herck K, Van Der Meeren O, Crasta P, Van Damme P, Hens N. Long-term antibody persistence after vaccination with a 2-dose Havrix™ (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions. Vaccine 2015; 33(42): 5723-7.
[http://dx.doi.org/10.1016/j.vaccine.2015.07.008] [PMID: 26190091]
[83]
Pijlman GP, Suhrbier A, Khromykh AA. Kunjin virus replicons: An RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applications. Expert Opin Biol Ther 2018; 6(2): 135-45.
[http://dx.doi.org/10.1517/14712598.6.2.135]
[84]
Lundstrom K. Latest development on RNA-based drugs and vaccines. Future Sci OA 2018; 4(5): 0151.
[http://dx.doi.org/10.4155/fsoa-2017-0151]
[85]
Granstein RD, Ding W, Ozawa H. Induction of anti-tumor immunity with epidermal cells pulsed with tumor-derived RNA or intradermal administration of RNA. J Invest Dermatol 2000; 114(4): 632-6.
[http://dx.doi.org/10.1046/j.1523-1747.2000.00929.x] [PMID: 10733665]
[86]
Kreiter S, Selmi A, Diken M, et al. Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res 2010; 70(22): 9031-40.
[http://dx.doi.org/10.1158/0008-5472.CAN-10-0699] [PMID: 21045153]
[87]
Rosa SS, Prazeres DMF, Azevedo AM, Marques MPC. mRNA vaccines manufacturing: Challenges and bottlenecks. Vaccine 2021; 39(16): 2190-200.
[http://dx.doi.org/10.1016/j.vaccine.2021.03.038] [PMID: 33771389]
[88]
Kuzmin IV, Rupprecht CE. Rabies virus. In: Encyclopedia of Virology. Elsevier 2008; pp. 367-73.
[http://dx.doi.org/10.1016/B978-012374410-4.00482-9]
[89]
Rabies vaccine, human diploid cell Pregnancy and Breastfeeding Warnings. 2019. Available from: https://www.drugs.com/pregnancy/rabies-vaccine-human-diploid-cell.html (Accessed: Sep. 28, 2022)
[90]
Brady AG, Carville AA. Digestive system diseases of nonhuman primates. In: Nonhuman Primates in Biomedical Research. Elsevier 2012.
[http://dx.doi.org/10.1016/B978-0-12-381366-4.00012-2]
[91]
Bhalla P, Forrest GN, Gershon M, et al. Disseminated, persistent, and fatal infection due to the vaccine strain of varicella-zoster virus in an adult following stem cell transplantation. Clin Infect Dis 2015; 60(7): 1068-74.
[http://dx.doi.org/10.1093/cid/ciu970] [PMID: 25452596]
[92]
Libbey JE, Fujinami RS. Adaptive immune response to viral infections in the central nervous system. In: InHandbook of clinical neurology. Elsevier 2014.
[http://dx.doi.org/10.1016/B978-0-444-53488-0.00010-9]
[93]
Azap A, Pehlivanoglu F. Measles Emerging Infectious Diseases: Clinical Case Studies. Elsevier Inc. 2014; pp. 346-57.
[http://dx.doi.org/10.1016/B978-0-12-416975-3.00026-1]
[94]
Moss WJ, Griffin DE, Feinstone WH. Measles. In: Vaccines for Biodefense and Emerging and Neglected Diseases. Elsevier 2009; pp. 551-65.
[http://dx.doi.org/10.1016/B978-0-12-369408-9.00030-5]
[95]
Maurice R. Hilleman, PhD, DSc. Semin Pediatr Infect Dis 2005; 16(3): 225-6.
[http://dx.doi.org/10.1053/j.spid.2005.05.002] [PMID: 16044396]
[96]
Kowalzik F, Faber J, Knuf M. MMR and MMRV vaccines. Vaccine 2018; 36(36): 5402-7.
[http://dx.doi.org/10.1016/j.vaccine.2017.07.051] [PMID: 28757060]
[97]
Groseth A, Feldmann H, Strong JE. The ecology of Ebola virus. Trends Microbiol 2007; 15(9): 408-16.
[http://dx.doi.org/10.1016/j.tim.2007.08.001] [PMID: 17698361]
[98]
Formenty P. Ebola virus disease. In: Emerging Infectious Diseases. Academic Press 2014; pp. 121-34.
[http://dx.doi.org/10.1016/B978-0-12-416975-3.00009-1]
[99]
Sharma AR, Lee YH, Nath S, Lee SS. Recent developments and strategies of Ebola virus vaccines. Curr Opin Pharmacol 2021; 60: 46-53.
[http://dx.doi.org/10.1016/j.coph.2021.06.008] [PMID: 34329960]
[100]
Marzi A, Robertson SJ, Haddock E, et al. VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain. Science 2015; 349(6249): 739-42.
[http://dx.doi.org/10.1126/science.aab3920] [PMID: 26249231]
[101]
Marzi A, Hanley PW, Haddock E, Martellaro C, Kobinger G, Feldmann H. Efficacy of vesicular stomatitis virus-Ebola virus postexposure treatment in rhesus macaques infected with Ebola virus Makona. J Infect Dis 2016; 214 (Suppl. 3): S360-6.
[http://dx.doi.org/10.1093/infdis/jiw218] [PMID: 27496978]
[102]
Beheshti M, Langsteger W, Rezaee A. PET/CT in cancer: An interdisciplinary approach to individualized imaging. Elsevier Health Sciences 2017.
[http://dx.doi.org/10.1016/B978-0-323-48567-8.00010-9]
[103]
HOWARD P. CHAPTER 20 - Prostate Cancer. In: Nutritional OncologyAcademic Press 2006.
[http://dx.doi.org/10.1016/B978-012088393-6/50076-2]
[104]
Nelson WG, Antonarakis ES, Carter HB, De Marzo AM, DeWeese TL. Prostate. Cancer Clin Oncol 2020; 1401-1432.e7.
[http://dx.doi.org/10.1016/B978-0-323-47674-4.00081-5]
[105]
Giles GG. Prostate Cancer. In: International Encyclopedia of Public Health. Academic Press 2008.
[http://dx.doi.org/10.1016/B978-012373960-5.00260-4]
[106]
Plosker GL. Sipuleucel-T. Drugs 2011; 71(1): 101-8.
[http://dx.doi.org/10.2165/11206840-000000000-00000] [PMID: 21175243]
[107]
Small EJ, Schellhammer PF, Higano CS, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006; 24(19): 3089-94.
[http://dx.doi.org/10.1200/JCO.2005.04.5252] [PMID: 16809734]
[108]
Reilly R. Breast Cancer xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc 2007; pp. 1-9.
[http://dx.doi.org/10.1016/B978-008055232-3.60809-8]
[109]
Romm A, Mills’ S, Hardy ML. Breast cancer. In: Botanical Medicine for Women’s Health. St. Louis, MO: Churchill Livingstone 2010; pp. 306-20.
[http://dx.doi.org/10.1016/B978-0-443-07277-2.00012-X]
[110]
Veronesi U, Boyle P. Breast Cancer. International Encyclopedia of Public Health 2017; pp. 272-80.
[http://dx.doi.org/10.1007/978-3-319-48848-6]
[111]
Holmes JP, Clifton GT, Patil R, et al. Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine. Cancer 2011; 117(3): 463-71.
[http://dx.doi.org/10.1002/cncr.25586] [PMID: 20845479]
[112]
Troy SB, Maldonado YA. Polioviruses. In: Principles and practice of pediatric infectious diseases. Elsevier 2012; pp. 1168-72.
[http://dx.doi.org/10.1016/B978-1-4377-2702-9.00237-3]
[113]
Ruiz SI, Zumbrun EE, Nalca A. Animal models of human viral diseases. In: Animal Models for the Study of Human Disease. Elsevier 2013.
[http://dx.doi.org/10.1016/B978-0-12-415894-8.00038-5]
[114]
Garg RR, Karst SM. Interactions between enteric viruses and the gut microbiota. In: Viral Gastroenteritis, Molecular Epidemiology and Pathogenesis. Academic Press 2016; pp. 535-44.
[http://dx.doi.org/10.1016/B978-0-12-802241-2.00026-2]
[115]
Sutter RW, Kew OM, Cochi SL, Aylward RB. Poliovirus vaccine-live. In: Plotkin’s Vaccines. 2018; pp. 866-917.e16.
[http://dx.doi.org/10.1016/B978-0-323-35761-6.00048-1]
[116]
Orimune (Oral Poliovirus Vaccine): Uses, Dosage, Side Effects, Interactions, Warning. Available from: https://www.rxlist.com/orimune-drug.htm#description (Accessed: Sep. 27, 2022)
[117]
Influenza LA. Influenza. In: Encyclopedia of Virology. Elsevier 2008; pp. 95-104.
[http://dx.doi.org/10.1016/B978-012374410-4.00654-3]
[118]
Thompson MG, Pierse N, Huang QS, et al. Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012–2015. Vaccine 2018; 3639: 5916-25.
[http://dx.doi.org/10.1016/j.vaccine.2018.07.028]
[119]
Ferdinands JM, Thompson MG, Blanton L, Spencer S, Grant L, Fry AM. Does influenza vaccination attenuate the severity of breakthrough infections? A narrative review and recommendations for further research. Vaccine 2021; 39(28): 3678-95.
[http://dx.doi.org/10.1016/j.vaccine.2021.05.011] [PMID: 34090700]
[120]
Heller R, Heller LC. Gene electrotransfer clinical trials. Adv Genet 2015; 89: 235-62.
[http://dx.doi.org/10.1016/bs.adgen.2014.10.006]
[121]
Choi YJ, Hur SY, Kim TJ, et al. A phase II, prospective, randomized, multicenter, open-label study of GX-188E, an HPV DNA vaccine, in patients with cervical intraepithelial neoplasia 3. Clin Cancer Res 2020; 26(7): 1616-23.
[http://dx.doi.org/10.1158/1078-0432.CCR-19-1513] [PMID: 31727676]
[122]
Home - ClinicalTrials.gov. Available from: https://clinicaltrials.gov/ (accessed Oct. 18, 2022)
[123]
Grünwald V, Weikert S, Schmidt-Wolf IGH, et al. Final results of patients with metastatic renal cell carcinoma treated with MGN1601 in the ASET study. J Clin Oncol 2014; 32(15) (Suppl.): e15590-0.
[http://dx.doi.org/10.1200/jco.2014.32.15_suppl.e15590]
[124]
McNeel DG, Becker JT, Eickhoff JC, et al. Real-time immune monitoring to guide plasmid DNA vaccination schedule targeting prostatic acid phosphatase in patients with castration-resistant prostate cancer. Clin Cancer Res 2014; 20(14): 3692-704.
[http://dx.doi.org/10.1158/1078-0432.CCR-14-0169] [PMID: 24850844]
[125]
Mohebtash M, Madan RA, Arlen PM, et al. Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 2009; 27(15) (Suppl.): 5144-4.
[http://dx.doi.org/10.1200/jco.2009.27.15_suppl.5144]
[126]
Heery CR, Palena C, McMahon S, et al. Study of a poxviral TRICOM-based vaccine directed against the transcription factor brachyuryphase I trial of MVA-Brachyury-TRICOM. Clin Cancer Res 2017; 23(22): 6833-45.
[http://dx.doi.org/10.1158/1078-0432.CCR-17-1087] [PMID: 28855356]
[127]
Dondulkar A, Akojwar N, Katta C, et al. Inhalable polymeric micro and nano-immunoadjuvants for developing therapeutic vaccines in the treatment of non-small cell lung cancer. Curr Pharm Des 2022; 28(5): 395-409.
[http://dx.doi.org/10.2174/1381612827666211104155604] [PMID: 34736378]
[128]
Backhaus P, Noto B, Avramovic N, et al. Targeting PSMA by radioligands in non-prostate disease-current status and future perspectives. Eur J Nucl Med Mol Imaging 2018; 45(5): 860-77.
[http://dx.doi.org/10.1007/s00259-017-3922-y] [PMID: 29335762]
[129]
Christopher RH. Phase I study of a poxviral tricom-based vaccine directed against the transcription factor brachyury. Clin Cancer Res 2017; 23(22): 6833-45.
[130]
Markowitz J. IFx-Hu2.0 phase I first in human study for unresectable melanoma for an intralesional ‘in-situ vaccine’ approach. J Clin Oncol 2022; 40(16)
[http://dx.doi.org/10.1200/JCO.2022.40.16_suppl.e21542]
[131]
Konno R, Yoshikawa H, Okutani M, et al. Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical intraepithelial neoplasia and cervical infection in young Japanese women. Hum Vaccin Immunother 2014; 10(7): 1781-94.
[http://dx.doi.org/10.4161/hv.28712] [PMID: 25424783]
[132]
Cafri G, Gartner JJ, Zaks T, et al. mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer. J Clin Invest 2020; 130(11): 5976-88.
[http://dx.doi.org/10.1172/JCI134915] [PMID: 33016924]
[133]
Karras NA, Weeres M, Sessions W, et al. A randomized trial of one versus two doses of influenza vaccine after allogeneic transplantation. Biol Blood Marrow Transplant 2013; 19(1): 109-16.
[http://dx.doi.org/10.1016/j.bbmt.2012.08.015] [PMID: 22940056]
[134]
Sabari J, Ramirez KA, Schwarzenberger P, et al. Abstract B209: Phase 1/2 study of mRNA vaccine therapy + durvalumab (durva) ± tremelimumab (treme) in patients with metastatic non-small cell lung cancer (NSCLC). Cancer Immunol Res 2019; 7(2) (Supplement): B209-9.
[http://dx.doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B209]
[135]
Yu J, Sun H, Cao W, Song Y, Jiang Z. Research progress on dendritic cell vaccines in cancer immunotherapy. Exp Hematol Oncol 2022; 11(1): 3.
[http://dx.doi.org/10.1186/s40164-022-00257-2] [PMID: 35074008]
[136]
Poddighe D, Castelli L, Marseglia GL, Bruni P. A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: Might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder? Immunol Res 2014; 60(2-3): 236-46.
[http://dx.doi.org/10.1007/s12026-014-8575-3] [PMID: 25388965]
[137]
Stübgen JP. Immune-mediated myelitis following hepatitis B vaccination. Autoimmun Rev 2012; 12(2): 144-9.
[http://dx.doi.org/10.1016/j.autrev.2012.03.008] [PMID: 22498789]
[138]
Hollingsworth RE, Jansen K. Turning the corner on therapeutic cancer vaccines. NPJ Vaccines 2019; 4(1): 7.
[http://dx.doi.org/10.1038/s41541-019-0103-y] [PMID: 30774998]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version339msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[08:57:38] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[08:57:38] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[08:57:38] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[08:57:38] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (107ms)time
  • Application (232ms)time
  • 1 x Application (68.45%)
    232ms
    1 x Booting (31.55%)
    107ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    36 statements were executed, 4 of which were duplicates, 32 unique. Show only duplicated129ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51727266','',1,1740473858,1740473858) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740473858
      2msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51727266','/article/136052',1,1740473858,1740473858)
      230μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) limit 1
      17.41msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51727266
      • 1: 51727266
      • 2: 51727266
      • 3: 51727266
      • 4: 51727266
      • 5: 51727266
      • 6: 51727266
      • 7: 51727266
      • 8: 51727266
      • 9: 51727266
      • 10: 51727266
      • 11: 51727266
      • 12: 51727266
      • 13: 51727266
      • 14: 51727266
      • 15: 51727266
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=136052
      960μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 63 limit 1
      1.13msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 63
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=63) and sj.journal_id!=63 group by `j`.`nid`) as `aggregate_table`
      1.44msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=63) and sj.journal_id!=63 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      1.29msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=63) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      2.45msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=63) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      2.16msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '136052'
      280μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 136052
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '136052'
      4.26msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 136052
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '136052' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 136052
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      350μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      730μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 63 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      51.85msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 63 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      6.24msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 63 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      5.29msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 136052 limit 1
      260μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 136052
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 136052 and content_type = 'article' order by status desc limit 1
      350μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 223418 limit 1
      270μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 223418
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      300μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'RRCT' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      360μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: RRCT
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '136052' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      570μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '13143' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      840μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3506' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3506) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3506) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3506)
      14.47msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13143) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13143) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13143)
      930μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 136052) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 136052) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473858 and j.to_date >= 1740473858 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 136052)
      860μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '7' and is_uploaded = 1 and issue_id = 13143 order by cast(first_page as SIGNED) desc limit 1
      690μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 7
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '33' and is_uploaded = 1 and issue_id = 13143 order by cast(first_page as SIGNED) asc limit 1
      590μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 33
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      230μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      240μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 136052 limit 1
      3.83msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 136052
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 63 and `b`.`banner_from_date` <= 1740473858 and `b`.`banner_to_date` >= 1740473858 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.56msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 63
      • 3: 1740473858
      • 4: 1740473858
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 63 and `b`.`banner_from_date` <= 1740473858 and `b`.`banner_to_date` >= 1740473858 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.13msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 63
      • 3: 1740473858
      • 4: 1740473858
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='6d68a030ec755019e10467f034fd57b1'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        CaioHU7bzdBX2PEE7O4mNxSHKmrq7zB3DrJqcvSN
        uc_cart_id
        6d68a030ec755019e10467f034fd57b1
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/136052" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/136052
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:8 [ "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        []
        
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 08:57:38 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ill2eXR5cUVDczZXSzh4cVJoWWd6VkE9PSIsInZhbHVlIjoiVlV0NUpBV2VTaXJpbzFWUy9UTHVENE1YTTN4SlpEOXY1Ky9KRFBYc0M1aHZzeTVrL0VYdHZkTmFaQnVzaHpVdjBYeWdzaG53UGpzdk5INUE4YXRiMVZEVzRpanBES09PT1FpZWlTb3RHeGxYU3ExdnJTOWFTaDkza200L29PWloiLCJtYWMiOiI5YTYyNzQwMTY2NmFlNWY3YTUyYWRjMzNjOTBkNmM5MzgyN2ZjNzYwY2YxMjcwMjFkYzEwM2I2ODc1YzM5ZjE0IiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 20:57:38 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ill2eXR5cUVDczZXSzh4cVJoWWd6VkE9PSIsInZhbHVlIjoiVlV0NUpBV2VTaXJpbzFWUy9UTHVENE1YTTN4SlpEOXY1Ky9KRFBYc0M1aHZzeTVrL0VYdHZkTmFaQnVzaHpVdjBYeWdza" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZXd3VEM2RMT1prcEh6V3p3OXVvWFE9PSIsInZhbHVlIjoiaHRNWE5hdlY3Z2tSZ2JtS2MvZWNXWjV3UUxIWWNjQWhPbFowQmdRaDBKK2pQWFZIMGs4UHdMTmRWdWNEZ2ZIYW9qbjZVMFZSdDFuamU1S0E1cnVhVEE5RGVxWVBobUc4UmFWZHMzVGJuUXk5STE2Z04wdjUxTUdwYkI1MmNxR1EiLCJtYWMiOiIyMzcxMjg4ZTc0NjI1MDQzY2E0ZWJiMGJmMDUxMDkxMmI3ZDUyMDFiYjkyMmQwMzdiNzgzNTM2N2FmMzVjOTVjIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IjZXd3VEM2RMT1prcEh6V3p3OXVvWFE9PSIsInZhbHVlIjoiaHRNWE5hdlY3Z2tSZ2JtS2MvZWNXWjV3UUxIWWNjQWhPbFowQmdRaDBKK2pQWFZIMGs4UHdMTmR" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ill2eXR5cUVDczZXSzh4cVJoWWd6VkE9PSIsInZhbHVlIjoiVlV0NUpBV2VTaXJpbzFWUy9UTHVENE1YTTN4SlpEOXY1Ky9KRFBYc0M1aHZzeTVrL0VYdHZkTmFaQnVzaHpVdjBYeWdzaG53UGpzdk5INUE4YXRiMVZEVzRpanBES09PT1FpZWlTb3RHeGxYU3ExdnJTOWFTaDkza200L29PWloiLCJtYWMiOiI5YTYyNzQwMTY2NmFlNWY3YTUyYWRjMzNjOTBkNmM5MzgyN2ZjNzYwY2YxMjcwMjFkYzEwM2I2ODc1YzM5ZjE0IiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 20:57:38 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ill2eXR5cUVDczZXSzh4cVJoWWd6VkE9PSIsInZhbHVlIjoiVlV0NUpBV2VTaXJpbzFWUy9UTHVENE1YTTN4SlpEOXY1Ky9KRFBYc0M1aHZzeTVrL0VYdHZkTmFaQnVzaHpVdjBYeWdza" 1 => "alphaeurekaselectnet_session=eyJpdiI6IjZXd3VEM2RMT1prcEh6V3p3OXVvWFE9PSIsInZhbHVlIjoiaHRNWE5hdlY3Z2tSZ2JtS2MvZWNXWjV3UUxIWWNjQWhPbFowQmdRaDBKK2pQWFZIMGs4UHdMTmRWdWNEZ2ZIYW9qbjZVMFZSdDFuamU1S0E1cnVhVEE5RGVxWVBobUc4UmFWZHMzVGJuUXk5STE2Z04wdjUxTUdwYkI1MmNxR1EiLCJtYWMiOiIyMzcxMjg4ZTc0NjI1MDQzY2E0ZWJiMGJmMDUxMDkxMmI3ZDUyMDFiYjkyMmQwMzdiNzgzNTM2N2FmMzVjOTVjIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IjZXd3VEM2RMT1prcEh6V3p3OXVvWFE9PSIsInZhbHVlIjoiaHRNWE5hdlY3Z2tSZ2JtS2MvZWNXWjV3UUxIWWNjQWhPbFowQmdRaDBKK2pQWFZIMGs4UHdMTmR" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "CaioHU7bzdBX2PEE7O4mNxSHKmrq7zB3DrJqcvSN" "uc_cart_id" => "6d68a030ec755019e10467f034fd57b1" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/136052" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 08:57:38GET/article/136052414361