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Medicinal Chemistry

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ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

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Review Article

A Critical Review on Therapeutic Potential of Benzimidazole Derivatives: A Privileged Scaffold

Author(s): Ramalakshmi Natarajan, Padma Kumar*, Arunkumar Subramani, Amuthalakshmi Siraperuman, Prabakaran Angamuthu, Richie R. Bhandare and Afzal B. Shaik

Volume 20, Issue 3, 2024

Published on: 08 November, 2023

Page: [311 - 351] Pages: 41

DOI: 10.2174/0115734064253813231025093707

Price: $65

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Abstract

Benzimidazole nucleus is a predominant heterocycle displaying a wide spectrum of pharmacological activities. The privileged nature of the benzimidazole scaffold has been revealed by its presence in most small molecule drugs and in its ability to bind multiple receptors with high affinity. A literature review of the scaffold reveals several instances where structural modifications of the benzimidazole core have resulted in high-affinity lead compounds against a variety of biological targets. Hence, this structural moiety offers opportunities to discover novel, better, safe and highly potent biological agents. The goal of the present review is to compile the medicinal properties of benzimidazole derivatives with a focus on SAR (Structure-Activity Relationships).

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